Raynaud’s Syndrome Causes

Raynaud’s syndrome is a rare disorder characterized by reduced blood flow to the body’s extremities, namely, the fingers and toes.

Picture of patient with RaynaudBarb Elkin | Shutterstock

Raynaud’s syndrome is characterized by narrowing of the blood vessels (vasospasm) in response to cold, stress, or emotional fluctuations. It is an episodic disorder, with a typical episode lasting for around 15 minutes.

Upon exposure to cold or stress, the skin turns white or blue due to a reduction in blood flow. Afterward, restoration of the blood flow results in reddening of the area and discomfort, such as numbness and prickling sensations.

Raynaud’s syndrome is categorized into two forms: primary and secondary Raynaud’s syndrome:

  • Primary Raynaud’s syndrome, or Raynaud’s disease, is the most common and least severe form in which no causative factor is directly associated with the hypersensitive blood vessel. However, it is believed that the primary form may be associated with impairment of the nervous system that regulates blood vessels.
  • Secondary Raynaud’s syndrome (or Raynaud’s phenomenon) is associated with some underlying health conditions including autoimmune disorders.

What causes Raynaud’s syndrome?

Although the exact etiology of Raynaud’s syndrome is not known, an excessive vasomotor response (a physiological process that controls the constriction and dilation of the blood vessel in response to temperature change or stress) is considered to be the major cause of this disorder.

An elevated vasomotor response may be associated with dysregulation of the nervous system that regulates muscle cells in the blood vessel responsible for its constriction and dilation.

When exposed to cold temperatures, blood vessels near the body surface constrict to keep the warm blood in the core body area. Similarly, in stressful conditions, surface blood vessels constrict to facilitate the fight-or-flight response. To some extent, these processes contribute to the development of Raynaud’s disease in response to stress and cold.

What causes secondary Raynaud's syndrome?

Secondary Raynaud's disease is caused by an underlying condition. The diseases that are most frequently associated with secondary Raynaud’s syndrome include lupus, scleroderma, CREST syndrome, Buerger’s disease, Sjögren’s syndrome, rheumatoid arthritis, atherosclerosis, polymyositis, cryoglobulinemia, thyroid disorders, and pulmonary hypertension.

These disorders typically fall into the following categories:

Arterial disorders

Diseases that affect blood vessels, such as atherosclerosis (plaque buildup in the arteries that supply the heart; Buerger’s disease (inflammation and thrombosis in blood vessels of the hands and feet); and primary pulmonary hypertension (high blood pressure that affects lung arteries)

Connective tissue disorders

Scleroderma (a rare condition characterized by hardening and scarring of the skin) is frequently associated with Raynaud’s syndrome. Other connective tissue disorders linked to this condition include lupus, rheumatoid arthritis, and Sjögren’s syndrome.

Carpal tunnel syndrome

Carpal tunnel syndrome is caused by pressure on a major nerve in the hands, which results in numbness and pain. This makes the hands more susceptible to Raynaud's syndrome.


Repetitive work such as typing, or the use of vibrating tools, such as jackhammers, increases the risk of developing Raynaud’s syndrome.


Hand or feet injuries, such as wrist fracture, surgery, or frostbite, can lead to a reduced sensitivity to cold temperatures.

Other causes:

  • Smoking – constriction of blood vessels due to excessive smoking.
  • Medications – medicines that are used to treat high blood pressure, such as beta blockers; certain migraine medications; attention-deficit/hyperactivity disorder medicines; certain chemotherapeutic agents; and medicines that cause narrowing of blood vessels, such as over-the-counter cold medications.

Last Updated: Jan 16, 2019

Dr. Sanchari Sinha Dutta

Written by

Dr. Sanchari Sinha Dutta

Dr. Sanchari Sinha Dutta is a science communicator who believes in spreading the power of science in every corner of the world. She has a Bachelor of Science (B.Sc.) degree and a Master's of Science (M.Sc.) in biology and human physiology. Following her Master's degree, Sanchari went on to study a Ph.D. in human physiology. She has authored more than 10 original research articles, all of which have been published in world renowned international journals.


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