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Chinese scientists establish synthesis of promising compound to fight against pancreatic cancer

Intriguing antitumor activity is found in a very promising class of natural compounds: cyclic depsipeptides, which have a challenging structure that makes their investigation difficult. Now, Chinese scientists have established the synthesis of a member compound, which is especially promising in killing pancreatic cancer stem cells.

28 Oct 2017

Novel consortium aims to create new paradigm of cancer drug discovery

Scientists from two U.S. national laboratories, industry and academia today launched an unprecedented effort to transform the way cancer drugs are discovered by creating an open and sharable platform that integrates high-performance computing, shared biological data from public and industry sources and emerging biotechnologies to dramatically accelerate the discovery of effective cancer therapies.

27 Oct 2017

New concise guide to pharmacology offers key information on major drug targets

The Concise Guide to PHARMACOLOGY 2017/18 is now available in the British Journal of Pharmacology. Published by Wiley on behalf of the British Pharmacological Society, the 440 page guide includes overviews of key properties for close to 1,700 human drug targets, identifies 3,500 ligands including more than 2,400 synthetic organic molecules and over 50 antibodies.

27 Oct 2017

Genome-wide molecular tests can guide treatment in recurrent glioblastoma, study shows

Several patients with recurring glioblastoma, a deadly brain cancer, survived for more than a year in a clinical trial believed to be the first to use comprehensive DNA and RNA sequencing of a patient's tumor to inform treatment for these patients in real-time.

27 Oct 2017

Digital Pathology for Everyone

There are two problems that pathologists face today. The first is, that a pathologist’s diagnosis using tissue sections is becoming more complex. There are many more biomarkers, and clinicians now ask for a more precise diagnosis. Secondly, the number of pathologists worldwide is declining every day, as the profession is often overlooked in favor of other specializations.

From microDimensions - Bramlage Scientific GmbH 27 Oct 2017

Researchers provide new insight into how nematode's brain controls movement

The human brain is a mysterious supercomputer. Billions of neurons buzz within an intricate network that controls our every thought, feeling, and movement. And we've only just begun to understand how it all works.

26 Oct 2017

Wayne State researchers win NIH grant to uncover new antibiotic targets

A research team from Wayne State University has received a $1.85 million grant from the National Institute of General Medical Sciences of the National Institutes of Health for the project "Mechanisms of Non-Shine-Dalgarno Translation Initiation."

26 Oct 2017

New enzyme may one day enable genome surgery that erases harmful mutations

DNA editing just got a sharp, new pencil. Researchers have built an enzyme that can perform a previously impossible DNA swap, directly changing the DNA base pair from an A•T to a G•C.

26 Oct 2017

IBN researchers create DNA technology with two new genetic alphabets

Just like how alphabets are strung together to form words, our DNA is also strung together by alphabets to encode proteins. Our DNA contains only 4 natural genetic alphabets - A, C, G and T, which hold the blueprint for the production of proteins that make our bodies work.

26 Oct 2017

Porvair Sciences develops revolutionary ‘FlowerPlate’ microplate for m2p-labs

Porvair Sciences reports on the revolutionary “FlowerPlate” microplate developed and manufactured as an OEM product with and for m2p-labs in Germany.

26 Oct 2017

Timing of DNA damage within checkpoints matters to a cell's fate, study reports

DNA damage occurs routinely within your cells due to sun exposure, smoking and sometimes during the normal process of making new DNA.

26 Oct 2017

Study: New histone modifications link cellular metabolism to chromatin architecture

Scientists of Helmholtz Zentrum München and Ludwig-Maximilians-Universität Munich (LMU) have discovered that two new classes of histone modifications couple cellular metabolism to gene activity. The study was published in 'Nature Structural and Molecular Biology'.

26 Oct 2017

Pre-clinical study reports promising step forward in search for non-addictive painkillers

A pre-clinical study led by Indiana University scientists reports a promising step forward in the search for pain relief methods without the addictive side effects behind the country's current opioid addiction crisis.

25 Oct 2017

New analysis method allows to efficiently search for gene transfers onto Y chromosome

Y chromosomes, which are only inherited paternally, evolved from "normal" chromosomes known as autosomes. As males only possess one Y chromosome, there is no counterpart for recombination, the direct exchange of genetic material.

25 Oct 2017

Researchers discover mechanism that corrects protein misfolding in plants

Various human nervous system diseases, such as amyotrophic lateral sclerosis (ALS), Alzheimer's, Huntington's, and Parkinson's diseases, are associated with the same basic disorder: the loss of nerve cells capacity to fold their proteins correctly, which causes protein aggregations that form "clumps" that end up generating the cell death.

25 Oct 2017

New discovery could speed development and approval of antiviral drugs

New research shows that a new class of antiviral drugs works by causing the virus' replication machinery to pause and backtrack, preventing the virus from efficiently replicating. This discovery, made possible by a high-throughput experimental technique called "magnetic tweezers," could speed the development and approval of related antiviral drugs.

25 Oct 2017

Scientists discover 'molecular pencil sharpener' that releases powerful antibiotics

Picture a brand-new, unsharpened pencil. The graphite at its core can't be used for writing until a pencil sharpener chews away its wooden tip.

24 Oct 2017

Scientists develop unique CRISPR-based method for more precise, systematic gene tagging

The genome editing tool known as CRISPR/Cas9 has opened many doors for biomedical research by allowing scientists to precisely edit DNA sequences and alter function. The technology offers hope for correcting genetic defects and preventing disease.

24 Oct 2017

New genetic variants contribute to the risk of breast cancer in women, study reveals

A new study reveals seventy-two novel genetic variants that are responsible for breast cancer risk. Published in the journals Nature and Nature Genetics, of these 72 variants, 65 are common variants that predispose patients to breast cancer and a further seven variants predispose particularly to estrogen -receptor negative breast cancer - the subcategory of cases that do not respond to hormonal treatments.

24 Oct 2017

Mysterious DNA modification appears more in the brain under stress

With advances in genomics, scientists are discovering additional components of the DNA alphabet in animals. Do these unusual chemical modifications of DNA have a special meaning, or are they just signs that cellular machines are making mistakes?

24 Oct 2017

Life Science News

Chinese scientists establish synthesis of promising compound to fight against pancreatic cancer

Novel consortium aims to create new paradigm of cancer drug discovery

New concise guide to pharmacology offers key information on major drug targets

Genome-wide molecular tests can guide treatment in recurrent glioblastoma, study shows

Digital Pathology for Everyone

Researchers provide new insight into how nematode's brain controls movement

Wayne State researchers win NIH grant to uncover new antibiotic targets

New enzyme may one day enable genome surgery that erases harmful mutations

IBN researchers create DNA technology with two new genetic alphabets

Porvair Sciences develops revolutionary ‘FlowerPlate’ microplate for m2p-labs

Timing of DNA damage within checkpoints matters to a cell's fate, study reports

Study: New histone modifications link cellular metabolism to chromatin architecture

Pre-clinical study reports promising step forward in search for non-addictive painkillers

New analysis method allows to efficiently search for gene transfers onto Y chromosome

Researchers discover mechanism that corrects protein misfolding in plants

New discovery could speed development and approval of antiviral drugs

Scientists discover 'molecular pencil sharpener' that releases powerful antibiotics

Scientists develop unique CRISPR-based method for more precise, systematic gene tagging

New genetic variants contribute to the risk of breast cancer in women, study reveals

Mysterious DNA modification appears more in the brain under stress

E-Cigarettes and Ethanol: A forensic Perspective on Vaping

Understanding Consumer-Consented Data to Optimize Digital Health Programs

The Future is Wearable: Advancing Human Health Through Portable Spectroscopy

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