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Researchers uncover molecular and clinical role of irisin in humans

A research team led by Dr. Christos Mantzoros, MD, PhD, at Beth Israel Deaconess Medical Center, Harvard Medical School, has published new findings elucidating the molecular and clinical role of FNDC5/irisin in humans.

1 Oct 2012

Administering immunotherapy for three years can reduce allergies, asthma in children

When children suffer from dust mite induced allergies and asthma, finding relief can seem impossible. While there isn't a complete cure for childhood respiratory allergies, researchers have found that long term control of allergic asthma can occur after only three years of allergy shots.

1 Oct 2012

Exelixis announces interim data from cabozantinib phase 2 trial on metastatic CRPC

Exelixis, Inc. today announced interim data from 51 patients with metastatic castration-resistant prostate cancer (CRPC) and bone metastases receiving a 40 mg daily dose of cabozantinib in an ongoing non-randomized expansion (NRE) cohort of a phase 2 randomized discontinuation trial.

1 Oct 2012

Researchers track spread of human invasive non-Typhoidal Salmonella in sub-Saharan Africa

A new study out today (Sunday 30 September) reveals that the emergence and spread of a rapidly evolving invasive intestinal disease, that has a significant mortality rate (up to 45%) in infected people in sub-Saharan Africa, seems to have been potentiated by the HIV epidemic in Africa.

1 Oct 2012

Death rates after surgery: an interview with Dr Rupert Pearse

There are very few published estimates describing the number of deaths following surgery at a national level and none at an international level.

1 Oct 2012

Researchers identify how p110delta molecule controls the body's inflammatory responses

Researchers at Queen Mary, University of London have discovered how a key molecule controls the body's inflammatory responses. The molecule, known as p110delta, fine-tunes inflammation to avoid excessive reactions that can damage the organism.

1 Oct 2012

Heavy drinkers and smokers may develop pancreatic cancer earlier in life

Those who smoke and drink heavily may develop pancreatic cancer at an earlier age than those who don't, according to a study led by a University of Michigan Health System gastroenterologist.

1 Oct 2012

Combination of dabrafenib and trametinib delays development of treatment resistance in MM patients

Combined treatment with two drugs targeting different points in the same growth-factor pathway delayed the development of treatment resistance in patients with BRAF-positive metastatic malignant melanoma.

1 Oct 2012

New insights on global fight to prevent cancers

New insights on the global fight to prevent cancers were presented during the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna. The studies highlight the challenges of overcoming misunderstandings about how important lifestyle factors are in reducing cancer risk.

1 Oct 2012

Serious physical abuse on the rise among children

A new Yale School of Medicine study shows that cases of serious physical abuse in children, such as head injuries, burns, and fractures, increased slightly by about 5% in the last 12 years. This is in sharp contrast to data from child protective services agencies, which show a 55% decrease in physical abuse cases from 1997 to 2009.

1 Oct 2012

Crizotinib effectively treats patients with ALK-positive lung cancer

The results of a new phase III trial show that crizotinib, a targeted therapy, is a more effective treatment than standard chemotherapy for patients with advanced, ALK-positive lung cancer, researchers said at the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna.

1 Oct 2012

Exercise can improve overall brain function following stroke

Just six months of exercise can improve memory, language, thinking and judgment problems by almost 50 per cent, says a study presented today at the Canadian Stroke Congress.

1 Oct 2012

Common RNA pathway links frontotemporal lobar dementia with ALS

Two proteins previously found to contribute to ALS, also known as Lou Gehrig's disease, have divergent roles. But a new study, led by researchers at the Department of Cellular and Molecular Medicine at the University of California, San Diego School of Medicine, shows that a common pathway links them.

1 Oct 2012

Exelix reports preliminary data from cabozantinib phase 1 study on solid tumors

Exelixis, Inc. today reported preliminary data from an ongoing phase 1 dose escalation study of cabozantinib in Japan.

1 Oct 2012

Precyse releases new report on ICD-10

Precyse, a leader in health information management (HIM) technologies and services, leading up to the 2012 American Health Information Management Association (AHIMA) Convention and Exhibit, released a new report titled, "Breaking the Code: The Impact of ICD-10 on Documentation and CDI Drives the Need for Organization-Wide Education."

1 Oct 2012

CIB2 genetic mutation responsible for deafness associated with Usher syndrome type 1

Researchers at the University of Cincinnati (UC) and Cincinnati Children's Hospital Medical Center have found a new genetic mutation responsible for deafness and hearing loss associated with Usher syndrome type 1.

1 Oct 2012

New trial results on pazopanib and temsirolimus have important implications for patients with RCC

New results from phase III trials exploring treatment options for patients with advanced renal cell carcinoma were released at the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna.

1 Oct 2012

Rehabilitation robots help identify and customize post-stroke therapy

When it comes to stroke rehabilitation, it takes a dedicated team to help a person regain as much independence as possible: physicians, nurses, physiotherapists, occupational therapists, speech-language pathologists, recreation therapists, caregivers and others. Now, a University of Calgary research team has added a robot to help identify and customize post-stroke therapy.

1 Oct 2012

HR status defines two different subsets of HER2 positive cancers

Human epidermal growth factor (HER2) positive breast cancers are often treated with the same therapy regardless of hormone receptor status. New research published in BioMed Central's open access journal Breast Cancer Research shows that women whose HER2 positive cancer was also hormone (estrogen and progesterone) receptor (HR) negative had an increased risk of early death, and that their cancer was less likely to recur in bone than those whose cancer retained hormone sensitivity.

1 Oct 2012

People with SIRT1 genetic variation more likely to develop vibration-induced white finger disease

Vibration-induced white finger disease (VWF) is caused by continued use of vibrating hand held machinery (high frequency vibration >50 Hz), and affects tens of thousands of people. New research published in BioMed Central's open access journal Clinical Epigenetics finds that people with a genetic polymorphism (A2191G) in sirtuin1 (SIRT1), a protein involved in the regulation of endothelial NOS (eNOS), are more likely to suffer from vibration-induced white finger disease.

1 Oct 2012

Medical News

Researchers uncover molecular and clinical role of irisin in humans

Administering immunotherapy for three years can reduce allergies, asthma in children

Exelixis announces interim data from cabozantinib phase 2 trial on metastatic CRPC

Researchers track spread of human invasive non-Typhoidal Salmonella in sub-Saharan Africa

Death rates after surgery: an interview with Dr Rupert Pearse

Researchers identify how p110delta molecule controls the body's inflammatory responses

Heavy drinkers and smokers may develop pancreatic cancer earlier in life

Combination of dabrafenib and trametinib delays development of treatment resistance in MM patients

New insights on global fight to prevent cancers

Serious physical abuse on the rise among children

Crizotinib effectively treats patients with ALK-positive lung cancer

Exercise can improve overall brain function following stroke

Common RNA pathway links frontotemporal lobar dementia with ALS

Exelix reports preliminary data from cabozantinib phase 1 study on solid tumors

Precyse releases new report on ICD-10

CIB2 genetic mutation responsible for deafness associated with Usher syndrome type 1

New trial results on pazopanib and temsirolimus have important implications for patients with RCC

Rehabilitation robots help identify and customize post-stroke therapy

HR status defines two different subsets of HER2 positive cancers

People with SIRT1 genetic variation more likely to develop vibration-induced white finger disease

How industrial hygiene flow calibration supports defensible exposure data

How electrical engineering ensures accurate calibration and patient safety

The importance of ketones from a clinical and medical perspective

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