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PHF20 transcriptional factor plays a unique role in regulating p53

Researchers at Moffitt Cancer Center and colleagues have identified PHF20, a novel transcriptional factor, and clarified its role in maintaining the stability and transcription of p53, a gene that allows for both normal cell growth and tumor suppression. PHF20, the researchers found, plays a previously unknown and unique role in regulating p53.

24 Aug 2012

Results from Biodesix VeriStrat phase II advanced lung cancer trials

Biodesix today announced that VeriStrat results from two phase II advanced lung cancer trials will be presented at the upcoming 2012 Chicago Multidisciplinary Symposium in Thoracic Oncology.

24 Aug 2012

Study helps explain how human airways clear sticky mucus out of the lungs

A runny nose and a wet cough caused by a cold or an allergy may not feel very good. But human airways rely on sticky mucus to expel foreign matter, including toxic and infectious agents, from the body.

24 Aug 2012

OUP, prestigious Royal Society of Tropical Medicine and Hygiene journals announce partnership

The Royal Society of Tropical Medicine and Hygiene's two prestigious journals will join the Oxford University Press (OUP) collection in a new partnership announced between the organizations.

24 Aug 2012

Influenza virus can change microRNA expression to control immune responses in human lung cells

When you are hit with the flu, you know it immediately -- fever, chills, sore throat, aching muscles, fatigue. This is your body mounting an immune response to the invading virus. But less is known about what is happening on the molecular level.

24 Aug 2012

MOZ protein could explain variations in severity of DiGeorge syndrome

The discovery of a 'switch' that modifies a gene known to be essential for normal heart development could explain variations in the severity of birth defects in children with DiGeorge syndrome.

24 Aug 2012

NW Bio receives MHRA approval to initiate DCVax-L Phase III GBM brain cancer trial in the U.K.

Northwest Biotherapeutics announced today that it has received approval from the Medicines and Healthcare Products Regulatory Agency (MHRA) of the United Kingdom, for the Company's 300-patient Phase III clinical trial of DCVax-L immune therapy for Glioblastoma multiforme brain cancer (GBM) to proceed in the U.K.

24 Aug 2012

NCKU research team identifies Au nanorod complex for cancer therapy

A National Cheng Kung University (NCKU) research team has discovered Near-Infrared Light-Responsive oligonucleotide-gated Au nanoensembles (Au nanorod complex), a potent new anti-cancer complex that is seen as a promising targeted therapy for curing cancer.

24 Aug 2012

AcelRx commences third ARX-01 Phase 3 study in post-operative pain

AcelRx Pharmaceuticals, Inc., a specialty pharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of acute and breakthrough pain, today announced dosing of the first patient in the third of three planned Phase 3 studies for ARX-01, the Sufentanil NanoTab PCA System, its novel sublingual patient-controlled analgesia (PCA) system.

24 Aug 2012

FDA approves Watson’s ANDA for lidocaine topical patch 5%

Watson Pharmaceuticals, Inc. today announced that its subsidiary, Watson Laboratories, Inc., has received final approval from the United States Food and Drug Administration (FDA) on its Abbreviated New Drug Application (ANDA) for lidocaine topical patch 5%, the generic equivalent to Endo's Lidoderm.

24 Aug 2012

Roundup: Ore. lawmakers examine 'disclosure' as way to limit malpractice claims; $2.8M in fraudulent public assistance given in Mass.; Md. exchange announcement Thursday

Lawmakers are expected to take up tort reform when the Oregon Legislature convenes next February. To get those discussions moving, a Patient Safety and Defensive Medicine Workgroup is developing draft legislation that includes issues such as confidentiality, mediation, dispute resolution, litigation, discovery and patient safety. Disclosure -- informing patients when a serious medical event has occurred in a hospital setting -- is also on the table.

24 Aug 2012

UK carotid endarterectomy results revealed

Round 4 of the UK Carotid Endarterectomy Audit, organized by the Royal College of Physicians, has revealed that the average delay from stroke or transient ischemic attack symptom onset to surgery is shortening.

23 Aug 2012

Concern over ameba-infested tap water deaths

People with sinusitis who regularly treat their condition using nasal irrigation should be aware of a potential contamination risk associated with using inadequately filtered tap water, say US researchers.

23 Aug 2012

Inappropriate prescriptions for the elderly prevalent in primary care

One in five prescriptions in primary care for the elderly is inappropriate, say the authors of a systematic review.

23 Aug 2012

Hand-held CO2 monitors could improve school air quality

A new hand-held sensor may be the answer to improving air quality in schools, say researchers.

23 Aug 2012

Adult surgery rescues overcorrected club foot deformity

Study findings support the use of supramalleolar osteotomy for patients with hindfoot valgus or subtalar joint deformity following an overcorrected clubfoot.

23 Aug 2012

Novel questionnaire reliably assesses antiepileptic adverse effects in children

The adverse effects of antiepileptic drugs can be reliably measured in children from across the epilepsy spectrum in clinical and research settings with the novel Pediatric Epilepsy Side Effects Questionnaire, say US scientists.

23 Aug 2012

Poor affect recognition may not predict psychosis in high-risk patients

Decreased affect recognition is associated with psychosis vulnerability, but it is not a marker of conversion to psychosis in high-risk individuals, researchers report.

23 Aug 2012

Annual follow up after ESD for early gastric cancer recommended

Almost all recurrent lesions in gastric epithelial cancer could be cured by endoscopic submucosal resection with annual follow-up exams, say the authors of a Japanese study.

23 Aug 2012