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KI's chemical interaction map shows how inhibitors bind to PARP enzymes

A team of researchers at Karolinska Institutet in Sweden has generated a map over the effects of small drug-like molecules on PARP1 and other similar proteins in the body. This map may explain the mechanism behind putative side effects of the so-called PARP inhibitors, and can play an important role in the development of novel tailor-made cancer drugs.

20 Feb 2012

neuGRID now expands globally to help find treatments for AD

neuGRID, a cloud-computing infrastructure funded by the European Commission that stores and analyses a vast database of 3D brain scans, is now expanding globally to help find treatments for Alzheimer's. This ground-breaking initiative will help develop a global online system to centralise and boost Alzheimer's research initiatives.

20 Feb 2012

ASI receives FDA clearance for GenASIs Scan and Analysis

Applied Spectral Imaging (ASI) announces that ASI's GenASIs automated scanning and image analysis system for detection and quantifying chromosome 17 and the HER-2/neu gene has been cleared by the United States Food and Drug Administration (FDA) for marketing in the US.

20 Feb 2012

Fast once or twice a week to improve brain health and prolong life

According to a team from the National Institute on Ageing in Baltimore, America, fasting for one or two days a week may protect against Alzheimer’s, Parkinson’s and other degenerative brain conditions.

20 Feb 2012

PIP breast implant removal and consultation costing the NHS large sums

After the Poly Implant Prothese (PIP) breast implant scare nearly 3,000 women have been seen by NHS specialists, of which over 1,000 have had scans and 67 have opted to have the implants removed, according to Department of Health statistics.

20 Feb 2012

DNA ‘nanorobot’ effectively targets cancer leaving healthy cells untouched: Study

Researchers have developed ‘nano-sized’ probes built from DNA that can seek and destroy cancer cells, leaving healthy cells untouched. These ‘nanorobots’ release their drug payload only when they reach and identify their target and are believed to improve many treatments for disease.

20 Feb 2012

Autism may be evident in an infant’s brain much earlier than thought: Study

Researchers have found that autism shows tell tale signs in babies as young as 6 months old — half a year or more before parents typically begin to notice symptoms of the condition. The results shed light on the fundamental differences in the brains of autistic children and could help lead to earlier detection and treatment, says co-author Geraldine Dawson, chief science officer at Autism Speaks, which helped fund the study in today's American Journal of Psychiatry.

20 Feb 2012

FDA to review inhaled caffeine device - AeroShot

The U.S. Food and Drug Administration (FDA) has announced its intentions of investigating whether inhalable caffeine sold in lipstick-sized canisters called AeroShot is safe for consumers and if its manufacturer was right to brand it as a dietary supplement.

20 Feb 2012

Massive infant Tylenol recall

Johnson & Johnson has announced the recall of its entire U.S. supply of infants' Tylenol—about 574,000 bottles—due to a design flaw. The flaw involved bottles of grape-flavoured infants' Tylenol, which had only just returned to shelves in November announced J&J last Friday.

20 Feb 2012

Deadly flu virus research may be published for the advancement of science but more risk assessment needed says WHO

According to the World Health Organization, the two controversial studies that explain how scientists mutated the H5N1 bird flu virus into a form that could cause a deadly human pandemic will be published only after experts fully assess the risks.

20 Feb 2012

Apixio introduces Clinical Knowledge Exchange at HIMSS 2012 conference

Apixio, Inc., the leading provider of clinical data integration, search and analytics for healthcare organizations, is introducing this week at the HIMSS 2012 conference, a technology framework called the Clinical Knowledge Exchange.

20 Feb 2012

CAI improves asthma outcomes and saves $1.46 for every dollar spent

Nearly 1 in 10 children have asthma, according to government statistics, and in low-income parts of Boston, nearly 16 percent of children are affected. A program called the Community Asthma Initiative (CAI), developed and implemented in 2005 by clinicians at Children's Hospital Boston, demonstrates the potential to dramatically reduce hospitalization and emergency department visits for asthma -- improving patient outcomes and saving $1.46 per dollar spent through reduced hospital utilization.

20 Feb 2012

Natural compound of Chilean avocado plant can combat resistant yellow staphylococci

Aggressive infections in hospitals are an increasing health problem worldwide. The development of bacterial resistance is alarming. Now a young Danish scientist has found a natural substance in a Chilean rainforest plant that effectively supports the effect of traditional treatment with antibiotics.

20 Feb 2012

Gender identity disorder linked with mental health risk in children

The first study to characterize a cohort of U.S. children with diagnosed gender identity disorder, led by researchers at Children's Hospital Boston, documents significant mental health risks as children struggle with strong feelings of being born "in the wrong body."

20 Feb 2012

New intraoral Tongue Drive System for high-level SCIs

The Tongue Drive System is getting less conspicuous and more capable. Tongue Drive is a wireless device that enables people with high-level spinal cord injuries to operate a computer and maneuver an electrically powered wheelchair simply by moving their tongues.

20 Feb 2012

EC approves Plexxikon's Zelboraf to treat BRAF mutation-positive MM

Plexxikon Inc., a member of Daiichi Sankyo Group, today announced that the European Commission has approved Zelboraf (vemurafenib) for the monotherapy treatment of adult patients with BRAFV600 mutation-positive unresectable or metastatic melanoma.

20 Feb 2012

Indiana CTSI HUB offers open-source software to accelerate clinical and translational research

At a time when medical research increasingly requires collaboration by large numbers of busy people, the Indiana Clinical and Translational Science Institute HUB offers a model for using advanced information technology to link scientists, health providers, community partners and others for the purpose of accelerating clinical and translational research.

20 Feb 2012

With contraception issue, Santorum highlights conservative credentials

Rep. Paul Ryan (R-Wis.), argued this morning on NBC's Meet the Press program that Obama's desire to have most religious hospitals provide birth control coverage to employees is "not an issue about contraception." ... But Rep. Chris Van Hollen (D-Md.) sharply disagreed, accusing Republicans of harping on "red-meat social issues that rile up their base."

20 Feb 2012

Researchers track structural changes during formation of new memories

New connections between brain cells emerge in clusters in the brain as animals learn to perform a new task, according to a study published in Nature on February 19 (advance online publication). Led by researchers at the University of California, Santa Cruz, the study reveals details of how brain circuits are rewired during the formation of new motor memories.

20 Feb 2012