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Study identifies USP15 as a critical protein in cancer

After years studying the molecular bases of glioblastoma - the most common brain tumor and one of the most aggressive of all cancers, the group led by Dr. Joan Seoane , Director of Translational Research at the Vall d'Hebron Institute of Oncology (VHIO) and ICREA Research Professor has today published a study in Nature Medicine identifying USP15 as a critical protein in cancer which, thanks to its molecular characteristics, shows enormous therapeutic promise.

20 Feb 2012

Modified imatinib cancer drug prevents morphine tolerance in rats

By reformulating the common cancer drug imatinib (Gleevec), researchers have eliminated morphine tolerance in rats - an important step toward improving the effectiveness of chronic pain management in patients, according to researchers at The University of Texas MD Anderson Cancer Center.

20 Feb 2012

ESOF 2012 science program launches today at AAAS meeting in Vancouver

The science program for Euroscience Open Forum 2012 (ESOF 2012) was officially launched today at the AAAS meeting in Vancouver.

20 Feb 2012

Smoke forecasting tools can help protect individuals and public health professionals

Satellite images, air quality measurements and smoke forecasting models are useful tools to help individuals and public health professionals prepare for smoke episodes in areas at risk from forest fire smoke, according to University of British Columbia researcher Michael Brauer.

20 Feb 2012

Symposium discusses links between genetic, epigenetic and environmental influences on autism

Two UC Davis MIND Institute researchers will lead a symposium on relationships between genetic, epigenetic and environmental influences on the development of autism in children during the American Association for the Advancement of Science (AAAS) Annual Meeting, Feb. 16 -18 in Vancouver, Canada.

20 Feb 2012

Finnish researchers break ground in neonatal brain research

In the past few years, researchers at the University of Helsinki have made several breakthroughs in discovering how the brain of preterm babies work, in developing treatments to protect the brain, and in developing research methods suitable for hospital use.

20 Feb 2012

Study reveals potential strength of different anti-HIV combination drugs

Using a mathematical formula that carefully measures the degree to which HIV infection of immune system cells is stalled by antiretroviral therapy, AIDS experts at Johns Hopkins have calculated precisely how well dozens of such anti-HIV drugs work, alone or in any of 857 likely combinations, in suppressing the virus. Results of the team's latest research reveal how some combinations work better than others at impeding viral replication, and keeping the disease in check.

19 Feb 2012

Defects in GPR120 protein may lead to obesity and liver disease

Defects in a protein that functions as a dietary fat sensor may be a cause of obesity and liver disease, according to a study published in the journal Nature, led by researchers at Imperial College London. The findings highlight a promising target for new drugs to treat obesity and metabolic disorders.

19 Feb 2012

Researchers discover class of proteins that detect 'painful touch'

In two landmark papers in the journal Nature this week, scientists at The Scripps Research Institute report that they have identified a class of proteins that detect "painful touch."

19 Feb 2012

Penn oncologist to discuss role of autophagy in fighting cancer at AAAS annual meeting

Blocking autophagy -- the process of "self-eating" within cells -- is turning out to be a viable way to enhance the effectiveness of a wide variety of cancer treatments.

19 Feb 2012

Clazosentan drug shows promise against TBI in rats

A new drug is showing promise in shielding against the harmful effects of traumatic brain injury (TBI) in rats, according to a study that was released today and will be presented at the American Academy of Neurology's 64th Annual Meeting in New Orleans April 21 to April 28, 2012.

19 Feb 2012

Contraception fight heads to state legislatures, federal court

Republican lawmakers in a handful of states are opening another front in the war against President Obama's health care overhaul, seizing on the hot-button issue of birth control with bills that would allow insurance companies to ignore new federal rules requiring them to cover contraception. Measures introduced recently in Idaho, Missouri and Arizona would go beyond religious nonprofits and expand exemptions to secular insurers or businesses that object to covering contraception, abortion and sterilization.

19 Feb 2012

Protein fragments from yellow field pea seeds can lower blood pressure

There are lots of new ideas out there for giving you extra protection against chronic diseases through the food you eat. But many good ideas may never make it to market. Researchers at the University of Guelph, led by Brian McBride, have found a way to enrich milk with docosahexaeonic acid (DHA)-an essential nutrient that many people are lacking.

19 Feb 2012

Evolution of cancer genome to be discussed at 2012 AAAS annual meeting

Professor Mike Stratton, Director of the Wellcome Trust Sanger Institute, will speak about 'the evolution of the cancer genome' at the prestigious 2012 American Association for the Advancement of Science annual meeting. The AAAS annual meeting is one of the world's most widely recognized science events.

19 Feb 2012

Low dose carbon monoxide therapy can prevent fetal death

Heme oxygenase-1 is essential for the growth of blood vessels in the placenta and in establishing blood flow in the umbilical cord. Too little HO-1 can lead to a restriction in the growth of the fetus and even in fetal death and miscarriage. New research published in BioMed Central's open access journal Medical Gas Research has shown that low dose carbon monoxide therapy is able to restore placental function and prevent fetal death in mice, without any detrimental effects.

19 Feb 2012

Bristol-Myers Squibb awards 3 new grants to enhance HBV and HCV prevention, diagnosis and care

The Bristol-Myers Squibb Foundation has awarded three new grants to improve prevention, diagnosis and care of hepatitis B (HBV) and hepatitis C (HCV) in China and India as part of its Delivering Hope: Awareness, Prevention and Care umbrella program which is committed to reducing hepatitis-related health disparities in Asia.

19 Feb 2012

Botox efficacy uncertain in treating migraine says NICE

Botox – used as an anti-wrinkle agent - is unlikely to be recommended for the treatment of chronic migraines on the NHS in England and Wales. According to the National Institute for Health and Clinical Excellence (NICE) draft guidelines there is insufficient evidence that it works.

18 Feb 2012

Norovirus outbreak at the George Washington University campus

Officials at the university and the District of Columbia's Health Department confirmed 85 cases of the gastrointestinal illness were diagnosed since Monday. The virus was found in locations including the central Foggy Bottom campus and the Mount Vernon campus in Northwest Washington. Members of the university also reported cases off campus.

18 Feb 2012

Quit-smoking drug Chantix effective in cocaine and alcohol addiction

Varenicline is unique among anti-addiction medications in the way it affects the brain. Like nicotine, varenicline activates a specific receptor for a neurotransmitter called acetylcholine, but it does so less intensely than the active ingredient of cigarettes does. The net effect is that the drug seems to help by both cutting cravings and making the formerly desired drug less pleasant — without making non-drug pleasures less intense. Alcohol works on the same chemical receptors in the brain as nicotine, and it may enhance the pleasurable effects of smoking.

18 Feb 2012

Mars Inc. pledges to limit candy bars to 250 calories

Mars Inc., the makers of popular candy brands including Snickers, M&M's and Twix, have said that they would stop making chocolate products that exceed 250 calories by the end of next year. The privately-held company also makes Milky Way, 3Musketeers, Bounty, Skittles candies, Juicy Fruit chewing gum and Kudos bars.

18 Feb 2012