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Experimental insulin-like growth factor receptor inhibitor a clear clinical candidate for pancreatic cancer therapy

Researchers at Amgen are testing a fully human monoclonal antibody that inhibits the activity of insulin-like growth factors (IGF-1 and IGF-2) and appears to reduce pancreatic cancer cells in early testing, according to a report in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research.

14 Apr 2009

Exercise programmes reduce falls in seniors

Exercise programmes are an effective option for preventing falls among older people living in the community.

14 Apr 2009

Oral etoricoxib provides pain relief after surgery

Oral etoricoxib is at least as effective as other drugs commonly used for pain relief after surgery.

14 Apr 2009

Energy drinks bost performance in unexpected ways

Runners clutching bottles of energy drink are a common sight, and it has long been known that sugary drinks and sweets can significantly improve athletes' performance in endurance events.

14 Apr 2009

Nerve shock implant device may help bladder control in urinary incontinence

For people with urinary incontinence who have run out of options, an electrical device might help, according to a new Cochrane Library review.

14 Apr 2009

Deep brain stimulation effective for patients with primary generalized dystonia

A new study from Mount Sinai School of Medicine finds that deep brain stimulation (DBS) is a safe and effective treatment for patients with primary generalized dystonia (PGD).

14 Apr 2009

Combination inhaler might simplify asthma treatment

People suffering from chronic asthma might have a new treatment option that allows them to manage their condition with a single prescribed inhaler that contains two medicines, according to a new review.

14 Apr 2009

Cognitive behaviour therapy and behaviour therapy helps chronic pain sufferers

Cognitive Behaviour Therapy (CBT) and Behaviour Therapy (BT) show some effect in helping the disability associated with chronic pain, according to a Cochrane Systematic Review.

14 Apr 2009

No evidence to support practice of extracting baby canine teeth

The practice of extracting baby canine teeth to make way for adult canines that are erupting in the wrong place has no evidential basis, according to a new study by Cochrane Researchers.

14 Apr 2009

Geographic patterns of frequent mental distress

Frequent Mental Distress (FMD), defined as having 14 or more days in the previous month when stress, depression and emotional problems were not good, is not evenly distributed across the United States.

13 Apr 2009

When cancer cells can't let go

Like a climber scaling a rock face, a migrating cancer cell has to keep a tight grip on the surface but also let go at the right moment to move ahead.

13 Apr 2009

Visual impairment will increase as population ages, but treatment can mitigate effects

Health care providers can expect a significant increase in age-related macular degeneration as the baby boom generation reaches retirement age, according to a new study by researchers at RTI International and the Centers for Disease Control and Prevention.

13 Apr 2009

Three medical centers awarded funds to study generation of cardiac muscle cells

The American Heart Association, with support from the Jon Holden DeHaan Foundation, has awarded funding for three research centers to study the development and mechanisms of generating new cardiac muscle cells.

13 Apr 2009

You are what your mother did not eat during pregnancy

The new science of epigenetics explains how genes can be modified by the environment, and a prime result of epigenetic inquiry has just been published online in The FASEB Journal: You are what your mother did not eat during pregnancy.

13 Apr 2009

Therapeutic effect of imatinib improved with addition of chloroquine

The therapeutic effects of the blockbuster leukemia drug imatinib may be enhanced when given along with a drug that inhibits a cell process called autophagy, researchers from the Kimmel Cancer Center at Jefferson reported in the Journal of Clinical Investigation.

13 Apr 2009

Survey research looks at attitudes, obstacles to walking and biking to work

According to researchers with Kansas State University's Physical Activity and Public Health Laboratory, active commuting -- walking or biking to school or work -- can be an easy, effective and efficient way to integrate physical activity into the daily routine.

13 Apr 2009

Facebook lowers grades in college, according to pilot study

College students who use Facebook spend less time studying and have lower grade point averages than students who have not signed up for the social networking website, according to a pilot study at one university.

13 Apr 2009

Study of neighborhoods points to modifiable factors, not race, in cancer disparities

While cities have shown considerable racial disparities in cancer survival, those racial disparities virtually disappear among smaller populations, such as neighborhoods within that city.

13 Apr 2009

SIRT1 takes down tumors

Yuan et al. have identified another anti-cancer effect of the "longevity" protein SIRT1.

13 Apr 2009

Scientists uncover mimicry at the molecular level that protects genome integrity

The new study, which was published on April 12, 2009, in an advanced online edition of the journal Nature Structural & Molecular Biology, draws new parallels between the Rad60 DNA repair factor and SUMO, a small ubiquitin-like modifier, which are both essential for maintaining genome stability during replication.

13 Apr 2009