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Aripiprazole has potential for treating alcohol dependence

Aripiprazole is currently approved to treat bipolar disorder as well as schizophrenia. A new study has found that it significantly and dose-dependently increases the sedative effects of alcohol and, to a lesser degree, decreases the euphoric effects of alcohol. Future research will need to examine the beneficial versus the side effects of aripiprazole for treatment of alcohol dependence.

4 Apr 2008

Answer to troublesome question of why some genetic assoc. studies have failed replication attempts

A team of researchers from Harvard School of Public Health (HSPH), Brigham and Women's Hospital (BWH), and elsewhere have described a possible reason why some studies have been unable to replicate associations between genes and traits -- namely that the strength of a gene/trait association might vary with age and that current study designs typically fail to take that into account.

4 Apr 2008

Alcohol and malt liquor availability and promotion higher in African American inner cities

It appears that living in a poor neighborhood with a high concentration of African Americans is associated with greater alcohol availability and promotion - especially malt liquor - according to a recent study by University of Minnesota researchers.

4 Apr 2008

Alcohol alters prefrontal cortex activity through ion channel disruption

The prefrontal cortex (PFC) region of the brain is involved in decision making. New rodent findings show that PFC neuron N-methyl-D-aspartic acid (NMDA) receptors are especially sensitive to concentrations of alcohol achieved during drinking.

4 Apr 2008

Optimal level of anxiety

Anxiety gets a lot of bad press. Dwelling on the negative can lead to chronic stress and anxiety disorders and phobias, but evolutionarily speaking, anxiety holds some functional value.

4 Apr 2008

Random drug testing of high school students in public schools

A substantial proportion of the nation's public school districts have instituted random drug testing among their high school students, some possibly going beyond sanctions set by the U.S. Supreme Court, according to a study led by the Pacific Institute for Research and Evaluation (PIRE).

3 Apr 2008

Proteolix's Carfilzomib granted orphan drug designation

Proteolix, Inc. has announced that the U.S. Food and Drug Administration (FDA) has granted orphan drug designation to carfilzomib, a selective blocker of proteasome activity for the treatment of multiple myeloma.

3 Apr 2008

Seatbelts save fetuses

A new study could have a profound effect on fetal deaths and injuries caused by car accidents.

3 Apr 2008

New nano-engineered gel inhibits for spinal cord injury

A spinal cord injury often leads to permanent paralysis and loss of sensation below the site of the injury because the damaged nerve fibers can't regenerate.

3 Apr 2008

Obese pregnant women use more health care services

Obesity during pregnancy is associated with greater use of health care services and longer hospital stays, according to a study from the Centers for Disease Control and Prevention (CDC) and Kaiser Permanente Northwest Center for Health Research.

3 Apr 2008

Discovery of gene variant linked to nicotine addiction and lung cancer

Scientists have identified a genetic variant that not only makes smokers more susceptible to nicotine addiction but also increases their risk of developing two smoking-related diseases, lung cancer and peripheral arterial disease.

3 Apr 2008

Fluorodeoxyglucose positron emission tomography to help determine whether cognitive impairment will lead to Alzheimer's

With nearly 10 million baby boomers at risk for developing Alzheimer's disease, researchers are taking a closer look at a condition known as mild cognitive impairment.

3 Apr 2008

Leptospira licerasiae, a new species of infectious disease found in Amazon

While investigating the tropical disease leptospirosis in the Peruvian Amazon, an infectious disease specialist from the University of California, San Diego School of Medicine has uncovered new, emerging bacteria that may be responsible for up to 40 percent of cases of the disease.

3 Apr 2008

Nipah virus in rural India and Bangladesh

Nipah virus is a new and deadly brain and lung disease that emerged from Singapore and Malaysia ten years ago.

3 Apr 2008

Not all trans fats are bad for you

University of Alberta researcher Flora Wang found that a diet with enriched levels of trans vaccenic acid (VA) - a natural animal fat found in dairy and beef products - can reduce risk factors associated with heart disease, diabetes and obesity

3 Apr 2008

Mouse calls help search for emotion-controlling genes

Scientists have long known that emotions and other personality traits and disorders run together in families.

3 Apr 2008

Study identifies infection risks for patients with inflammatory bowel disease

A new Mayo Clinic study finds that patients who are 50 or older and take multiple immunosuppressive medications for inflammatory bowel disease have a higher risk for developing infections. The study is published in this month's issue of Gastroenterology.

3 Apr 2008

Sleep deprivation can cause sleepwalking

Somnambulism, which affects up to four percent of adults, can cause mental confusion or bouts of amnesia in those affected as they wander unresponsive to their environment.

3 Apr 2008

Disparities in postmastectomy breast reconstruction

In a new study examining disparities in postmastectomy breast reconstruction, researchers at Brigham and Women's Hospital (BWH) and Dana-Farber Cancer Institute (DFCI) in Boston, Mass., concluded that lack of patient-provider discussion may contribute to socioeconomic, age and race-related inconsistencies in the use of breast reconstruction after mastectomy.

3 Apr 2008