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Data suggesting that omacetaxine can eradicate leukemic stem cells may offer a breakthrough for CML

Data showing the ability of omacetaxine to kill leukemic stem cells in mouse models with drug-resistant chronic myelogenous leukemia (CML) are the subject of an advance online publication in the journal Leukemia, ChemGenex Pharmaceuticals Limited (ASX:CXS and NASDAQ:CXSP) announced today.

29 Mar 2009

Chronic obstructive pulmonary disease-related problems hard to swallow

Patients with moderate to severe chronic obstructive pulmonary disease (COPD) exhibit a disordered breathing-swallowing pattern that may account for their higher risk of aspiration pneumonia, according to new research from the University of Pittsburgh.

29 Mar 2009

Add-on treatment may reduce treatment-associated weight gain caused by antipsychotic treatments

Antipsychotic drugs, such as olanzapine (Zyprexa), risperidone (Risperdal) and quetiapine (Seroquel), are commonly used to treat psychotic disorders like schizophrenia, but also bipolar disorder and even behavioral problems related to dementia.

29 Mar 2009

Clarke clarifies pattern recognition theory

Recent commentary has suggested that the extent to which anomaly theories have become ingrained in the minds of academics and popular commentators alike has led to certain common assumptions and misconceptions about Clarke's pattern recognition theory of humour.

29 Mar 2009

Mutations in a gene may stunt lung development in children

Mutations in a gene may cause poor lung development in children, making them more vulnerable to diseases such as chronic obstructive pulmonary disease (COPD) later in life, say researchers at the University of Pittsburgh Graduate School of Public Health and the German Research Center for Environmental Health.

29 Mar 2009

Updated heart failure guidelines focus on key research findings, clinical advances

Updated guidelines on the diagnosis and management of heart failure will help physicians incorporate the latest research findings into the treatment of patients with this complex and disabling disease.

29 Mar 2009

Simple, noninvasive finger sensor test predicts major cardiac events

Results of a Mayo Clinic study show that a simple, noninvasive finger sensor test is "highly predictive" of a major cardiac event, such as a heart attack or stroke, for people who are considered at low or moderate risk, according to researchers.

26 Mar 2009

Psychiatric disorders common in adults who have had anorexia

Many adults who were diagnosed as teenagers to be suffering from anorexia nervosa cannot work due to psychiatric disorders. A follow-up 18 years after the onset of anorexia has shown that one in four are on disability benefit or have been signed off sick. The long-term follow-up by the Sahlgrenska Academy, University of Gothenburg, does, however, show some encouraging results.

26 Mar 2009

Male circumcision reduces risk of herpes simplex virus type 2 and human papillomavirus

Heterosexual men who undergo medical circumcision can significantly reduce their risk of acquiring two common sexually transmitted infections - herpes simplex virus type 2 (HSV-2), the cause of genital herpes, and human papillomavirus (HPV), which can cause cancer and genital warts, according to a report in the March 26 issue of the New England Journal of Medicine (NEJM).

26 Mar 2009

Polymer nanowires detect cancer biomarker

Investigators at the University of California, Riverside, have developed a simple and cost-effective method of building conducting polymer nanowires that can detect a wide range of levels of a cancer biomarker. This work, which was published in the journal Analytical Chemistry, could serve as a model for portable cancer detection equipment suitable for use in a doctor's office.

26 Mar 2009

Nanoparticles open door to cancer prevention

Perhaps the best way to fight cancer is to prevent it from developing in the first place, and based on newly published research from investigators at the University of Wisconsin-Madison, nanoparticles may be able to make cancer chemoprevention a reality.

26 Mar 2009

Safer nanoparticles spotlight tumors, deliver drugs

Small is promising when it comes to illuminating tiny tumors or precisely delivering drugs, but many worry about the safety of nanoscale materials.

26 Mar 2009

Twin nanoparticle shown effective at targeting, killing breast cancer cells

A team of investigators at Brown University has developed a novel way to treat a class of breast cancer cells. The team has created twin nanoparticles that specifically targets the Her-2 tumor cell and unload a cancer-fighting drug directly into it. The result is a boost in antitumor activity while minimizing side effects. The findings of this study have been published in the Journal of the American Chemical Society.

26 Mar 2009

Nanoparticles deliver gene therapy, killing tumors

Given that cancer is ultimately a genetic disease, it has long been the hope of researchers to use gene therapy to attack tumors where they might be most susceptible.

26 Mar 2009

Should all women be screened for domestic violence?

A screening programme which would require doctors and nurses to ask all women whether they have experienced domestic violence, whatever their reason for seeking medical attention, is not justified, according to a new report by researchers at the University of Bristol, funded by the National Institute for Health Research Health Technology Assessment (NIHR HTA) programme.

26 Mar 2009

Oxycodone effective against shingles pain

The painkiller oxycodone is effective at treating the acute pain of shingles, an illness that often causes severe pain which can become long-lasting and sometimes even permanent.

26 Mar 2009

Sagent Pharmaceuticals receives FDA approval of Azithromycin for injection

Sagent Pharmaceuticals, Inc. has announced U.S. Food and Drug Administration (FDA) approval of azithromycin for injection, a semi-synthetic, macrolide antibiotic that is used to treat a wide variety of bacterial infections. Sagent will offer azithromycin in a 500 mg vial for intravenous use.

26 Mar 2009

Discovery of new biomarker for prostate cancer

Researchers at Wayne State University have identified a new marker for prostate cancer progression that may one day lead to new treatments.

26 Mar 2009

National Urban League urges Obama to address racial health disparities in annual report

The National Urban League on Wednesday released its annual of "State of Black America" report, in which it urges President Obama to address health care and other disparities blacks face, the AP/Long Island Newsday reports.

25 Mar 2009

Facial flushing in East Asians who consume alcohol linked to esophageal cancer risks

About one-third of people of Chinese, Japanese and Korean descent have an enzyme deficiency that causes their face to flush when they drink alcohol, a trait that puts them at a higher risk for developing esophageal cancer, according to a study published in the journal PLoS Medicine, Reuters Health reports.

25 Mar 2009