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Pigs help study of links between polycystic ovary syndrome, obesity, cardiovascular disease and diabetes

Despite the exaggerated, wrinkly snout and long, coarse, spiky hair reminiscent of the 1980s television space alien ALF, some very special swine are helping researchers at Purdue and Indiana universities understand human infertility, diabetes and cardiovascular disease.

4 Apr 2006

HOXB13 and IL17BR genes predict outcome for breast cancer patients

The 2-gene expression profile of HOXB13 and IL17BR in a woman's breast cancer predicts risk of recurrence in node-negative patients treated with tamoxifen.

4 Apr 2006

Mayo Clinic discover cellular secret that may explain how certain cancers move and spread

If the mechanism that drives cancer movement - also called metastasis - can be understood well enough to manipulate it, new and better treatments can be developed for patients with metastatic cancers.

4 Apr 2006

Antioxidant therapy will be useful for women with pre-eclampsia

The antioxidant tempol prevents the onset of pre-eclampsia in pregnant mice, a finding that further implicates oxidative stress in the illness, which is widespread among pregnant women.

4 Apr 2006

Enzymes that harm brain immediately after stroke may be beneficial days later

Insights from the study could change the way stroke is treated, extending the window for effective treatment from a couple of hours to a couple of weeks. The results may suggest new ideas for drug development.

4 Apr 2006

New mouse model technology in cancer vaccine tool-box

Cancer vaccines are being investigated in early-phase clinical trials around the world, with many of those trials recruiting patients with melanoma.

4 Apr 2006

Link between lead and osteoporosis strengthens

Bolstered by recent laboratory findings, researchers at the University of Rochester Medical Center are embarking on a National Institutes of Health-funded clinical study to better understand the deceptive role environmental lead exposure plays in bone maturation and loss.

4 Apr 2006

Responding to AIDS, TB, Malaria and emerging infectious diseases in Burma

Government policies in Burma that restrict public health and humanitarian aid have created an environment where AIDS, drug-resistant tuberculosis, malaria and bird flu (H5N1) are spreading unchecked, according to a report by researchers at the Johns Hopkins Bloomberg School of Public Health.

4 Apr 2006

Effects of weight training on quality of life in recent breast cancer survivors

Weight training significantly improves the quality of life of women recently treated for breast cancer, according to a new study.

4 Apr 2006

Why do men choose one prostate cancer treatment over another?

Men with prostate cancer generally make treatment decisions based on differences in the information they receive rather than their own preferences, according to a new review.

4 Apr 2006

Targeting the inflamed synovium: The quest for specificity

In the April 2006 issue of Arthritis & Rheumatism, noted rheumatology specialists with Kings College London, Dr. Toby Garrood and Dr. Costantino Pitzalis offer an overview of recent breakthroughs and a preview of future directions in this critical quest for specificity.

4 Apr 2006

Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis

Inflammation, cartilage and bone erosions, joint destruction--that's the typical progression of arthritis and most rheumatic diseases.

4 Apr 2006

Targeting of angiogenic endothelial cells at sites of inflammation by Dexamethasone Phosphate-containing RGD peptide liposomes inhibits experimental arthritis

Vascular endothelial cells (VECs) form the walls of blood vessels and play a critical role in inflammation.

4 Apr 2006

New clinical trial to test different strengths of a vaccine designed to fight avian influenza

The Duke study is part of a multicenter trial that will test a modified form of an investigational bird flu vaccine to determine whether the vaccine still triggers a strong immune response at lower doses.

4 Apr 2006

Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep

While newly published research confirms that under laboratory circumstances prion-protein can be absorbed across the gut, it also shows that this is unlikely to occur in real life.

4 Apr 2006

Life or death can depend on teenage cancer patients taking their treatments properly

Teenagers and young adults with cancer need to understand the implications of not taking their treatments regularly, at the right time, and for the whole course. Those who don't are seriously compromising their future health - and for some it will be the difference between life and death.

4 Apr 2006

Natural killer cells and antibody-based immune function

A new drug may boost the effectiveness of a widely used treatment for patients with non-Hodgkin lymphoma (NHL), while simultaneously overcoming drug resistance in those patients.

4 Apr 2006

Researchers identify cell cue for destroying tumors

Mayo Clinic researchers have identified and characterized an important signal used by the human immune system to help destroy tumors.

4 Apr 2006

Immune response protects against brain tumor development

In their quest to determine whether immune system surveillance guards against brain tumor development, researchers at The University of Texas M. D. Anderson Cancer Center have found that allergies and asthma that stimulate inflammation may be protective, but use of antihistamines to control the inflammation could eliminate that protection.

4 Apr 2006

New biomarkers could help detect ovarian cancer much earlier

The search for a specific protein that could help diagnose ovarian cancer in its early stages has for years eluded researchers who are seeking a reliable and accurate test for the disease.

4 Apr 2006