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Chemical peroxynitrite tolerates pain

The repeated use of opiate drugs such as morphine to relieve chronic pain results in individuals having to take higher and higher doses of the drug to achieve equivalent pain relief (they are said to exhibit antinociceptive tolerance).

2 Nov 2007

Educating teens about the dangers of tobacco use

"As a teen, no one ever told us that cigarettes would affect our health," says Jerry Berkowitz, a throat cancer survivor who started smoking at age 13. "Everyone smoked."

2 Nov 2007

SENP1 protein may provide a basis for future targeted cancer therapies

Researchers at the University of Texas M. D. Anderson Cancer Center have found a protein that enables cellular survival during periods of low oxygen, or hypoxia, which also is key for development of many kinds of cancer.

2 Nov 2007

Substance abuse practitioners ask 'what is recovery?'

Abstinence from alcohol and drugs is just the starting point in defining "recovery" for people with substance abuse disorders, according to a paper in the October issue of the Journal of Substance Abuse Treatment (JSAT).

2 Nov 2007

Studies attribute recent increase in multiple myeloma survival to novel therapies

Multiple myeloma is one of the most common and devastating bone marrow cancers in the U.S., but survival rates have risen dramatically over the past decade.

2 Nov 2007

Psychological stress increases susceptibility to skin infections in mice

It is well known that being stressed increases our susceptibility to infections by impairing the function of our immune system, but the molecular links between stress and diminished immune function have not been determined.

2 Nov 2007

New understanding of gestational diabetes

A protein in the pancreas is giving researchers at the Stanford University School of Medicine their first chance at cracking the code that determines how diabetes develops during pregnancy, a finding that could lead to new treatments for all forms of diabetes.

2 Nov 2007

Anti-leukemia drug dexamethasone increases patient fatigue

The anti-leukemia drug dexamethasone contributes to a relentless fatigue and poor quality of sleep in children undergoing treatment for acute lymphoblastic leukemia (ALL), according to a new study from St. Jude Children's Research Hospital.

2 Nov 2007

Research sheds light on carotid artery stenting risk in elderly

Dr. Hernan Bazan, Assistant Professor of Surgery, Section of Vascular Surgery, at Louisiana State University Health Sciences Center New Orleans' School of Medicine, is the lead author of a research paper which may help physicians decide which patients with carotid artery occlusive disease should have carotid surgery or carotid stenting.

2 Nov 2007

California kids not being read to!

A new report reveals that California ranks in the bottom half of the nation - 42nd out of 50 states and the District of Columbia - in the percentage of children who are read to daily by their parents.

2 Nov 2007

Regulation of TATA-less promoters

In their upcoming G&D paper, Dr. Robert Tjian (UC Berkeley) and colleagues reveal how histone gene expression is differentially regulated during Drosophila development.

2 Nov 2007

Non-invasive radio waves heat up nanotubes to destroy cancer

Cancer cells treated with carbon nanotubes can be destroyed by non-invasive radio waves that heat up the nanotubes while sparing untreated tissue, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center and Rice University has shown in preclinical experiments.

2 Nov 2007

Prediabetes is a wake up call and a chance for lifestyle changes

New data suggests that 54 million Americans may be on track to develop diabetes within the next 10 years.

2 Nov 2007

Practice parameters discuss the evaluation, treatment of circadian rhythm sleep disorders

Practice parameters published in the November 1 issue of the journal SLEEP are a guide to the appropriate assessment and treatment of circadian rhythm sleep disorders (CRSDs).

2 Nov 2007

Enzyme sphingosine kinase 2 show to be potential new target to fight cancer

Researchers at the Virginia Commonwealth University Massey Cancer Center have identified the enzyme sphingosine kinase 2 as a possible new therapeutic target to improve the efficacy of chemotherapy for colon and breast cancer.

2 Nov 2007

PET scan distinguishes Alzheimer's from other dementia

A PET scan (positron emission tomography) that measures uptake of sugar in the brain significantly improves the accuracy of diagnosing a type of dementia often mistaken for Alzheimer's disease, a study led by a University of Utah dementia expert has found.

2 Nov 2007

Patients denied admission to intensive care because of doctors' pessimism

Doctors are overly pessimistic about the chances of survival for patients with COPD related attacks and, as a result, some patients may be denied admission to hospital for vital help, according to a study published on bmj.com.

2 Nov 2007

Overweight mothers run greater risk of having hyperactive children

If a woman is overweight when she becomes pregnant, the probability is much greater that her child will evince ADHD-like symptoms when he/she reaches school age, according to a new Nordic study.

2 Nov 2007

Discovery of master switch that regulates blood pressure

A team of Oregon Health & Science University researchers studying a rare form of hypertension has identified the mechanism by which they believe a protein complex in the kidney operates as a master switch that regulates blood pressure, a finding that has broad implications for the treatment of more common forms of hypertension.

2 Nov 2007