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Intensive care quality of sleep improved by new drug dexmedetomidine

A new sedative drug has been shown to improve the sleep quality and comfort levels of intensive care patients, compared to the most commonly-used medication, according to research published today in the journal JAMA.

13 Dec 2007

Immune compound blocks virus' ability to hijack antibodies

Researchers at Washington University School of Medicine in St. Louis have shown that a controversial phenomenon known as antibody-dependent enhancement (ADE) of infection is suppressed by C1q, a blood-borne immune system compound.

13 Dec 2007

GlaxoSmithKline response to JAMA article on ICES retrospective analysis

The following is GlaxoSmithKline's response to the retrospective analysis by the Institute for Clinical Evaluative Sciences (ICES) titled "Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes".

13 Dec 2007

'Informed cohort' provides personal stake in genetics research

Patients are often reluctant to give up DNA samples for research, not knowing what the information will be used for and feeling there's no personal benefit to them.

13 Dec 2007

Geriatric care intervention appears to provide some benefits for low-income seniors

A home-based geriatric care program for low-income seniors resulted in higher-quality medical care, improvement in quality of life and fewer emergency department visits, but did not appear to prevent decline in physical functioning, according to a study in the December 12 issue of JAMA: The Journal of the American Medical Association.

13 Dec 2007

Researchers find genetic switch for internal body clock

University of California, Irvine researchers have identified the chemical switch that triggers the genetic mechanism regulating our internal body clock.

13 Dec 2007

Variant of a tumor suppressor gene associated with aggressive prostate cancer

A variant of a tumor suppressor gene may be associated with an increased risk of aggressive prostate cancer, according to a study published online December 11 in the Journal of the National Cancer Institute.

13 Dec 2007

Female lower back has evolved to accommodate the weight of pregnancy

When a pregnant woman leans back, and shifts her weight to stand more comfortably, she is performing a motion that for millions of years has helped to compensate for the strain and weight of childbearing on the body.

13 Dec 2007

Australian researchers plan for a pandemic

Sydney researchers have produced useful food and nutrition guidelines for survival rations to be used in the event of a pandemic such as influenza which appear in this week's Medical Journal of Australia.

13 Dec 2007

Cell-tracking software speeds drug development

Time is money, especially in the race to discover new anti-inflammatory drugs and bring them to market.

13 Dec 2007

Caesareans births linked to increased risk of newborn respiratory problems.

Babies delivered by elective caesarean section around term carry up to a fourfold increased risk of breathing problems compared with babies delivered vaginally or by emergency caesarean section, concludes a study from Denmark published on bmj.com.

13 Dec 2007

Crimean Congo hemorrhagic fever virus strips away immune system's defensive measures

When the alert goes out that a virus has invaded the body, cells that have yet to be attacked prepare by "armoring" themselves for combat, attaching specific antiviral molecules to many of their own proteins to help resist the invader.

13 Dec 2007

Nematodes provide clues to dopamine's role in human aging diseases

Research carried out with a paintbrush bristle, a metronome, smelly chemicals and thousands of microscopic worms called nematodes may reveal important information about human aging diseases like Parkinson's and Alzheimer's, thanks to a grant from the Ellison Medical Foundation awarded to a University at Buffalo neurobiologist.

13 Dec 2007

Statins taken after stroke may increase risk of hemorrhagic stroke

People taking cholesterol-lowering drugs such as atorvastatin after a stroke may be at an increased risk of hemorrhagic stroke, or bleeding in the brain, a risk not found in patients taking statins who have never had a stroke.

13 Dec 2007

Secret lives of enzymes revealed

In a new study in Nature, Brandeis University Howard Hughes Medical Investigator Dr. Dorothee Kern and collaborators pull back the curtain on the secret lives of enzymes, the ubiquitous proteins that catalyze chemical reactions in the cell.

13 Dec 2007

Carbamazepine based drugs to include new advice for patients with Asian ancestry

The U.S. Food and Drug Administration today announced that the manufacturers of drugs containing the active ingredient carbamazepine have agreed to add to the drugs' labeling a recommendation that, before starting therapy with the drugs, patients with Asian ancestry get a genetic blood test that can identify a significantly increased risk of developing a rare, but serious, skin reaction.

13 Dec 2007