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Dll4 signalling through Notchi regulates formation of tip cells during angiogenesis

All tissues, sick and healthy alike, need a blood supply to survive and grow. The key to many medical problems, like preventing tumour development, is therefore to obstruct the spread of the blood vessels. Research scientists at Karolinska Institutet have now discovered a heretofore unknown mechanism for how the body links together its blood vessels.

29 Jan 2007

New understanding of cholera pathogen

Researchers at Rensselaer Polytechnic Institute have discovered new details about how bacteria generate energy to live. In two recently published papers, the scientists add key specifics to the molecular mechanism behind the pathogen that causes cholera.

29 Jan 2007

Photoprinted paper supports simultaneous microscale diagnostic tests

Prototype for a new class of inexpensive, highly practical rapid tests that can be used to carry out several biological tests simultaneously on a single drop.

29 Jan 2007

New mobile application for weight control

A Finnish research group with participants from VTT Technical Research Centre of Finland, the University of Tampere and Nokia Research Center has developed a new personal health diary for the mobile phone.

29 Jan 2007

Study "on-the-job physical activity" released

The American Council on Exercise (ACE) recently released results of its exclusive study that examined on-the-job physical activity of 10 common occupations.

29 Jan 2007

GlaxoSmithKline's new influenza vaccine accepted for review in Europe

GlaxoSmithKline has announced that its new generation H5N1 split antigen pre-pandemic influenza vaccine has been accepted for review by the Committee for Medicinal Products for Human Use (CHMP) in Europe.

29 Jan 2007

Public standards for world medications to treat neglected infectious diseases

The United States Pharmacopeia (USP) has released free documentary standards for medicines used outside the United States to treat neglected infectious diseases.

29 Jan 2007

AIDS Healthcare Foundation praises Thai action on AIDS drug licensing

AIDS Healthcare Foundation (AHF), the US' largest HIV/AIDS healthcare and prevention and education provider, which operates free AIDS treatment clinics in the US, Africa, Latin America/Caribbean and Asia, praised the Government of Thailand for its plan to break the patents on some lifesaving drugs, including one for an anti- retroviral drug used in the treatment of HIV/AIDS.

29 Jan 2007

Nanocarrier stimuli-activated gene delivery

One approach to developing tumor-specific drug delivery agents is to create nanomaterials that release a therapeutic payload only after reaching their intended target.

29 Jan 2007

Second-generation dendrimer disintegrates upon command

Dendrimers, highly branched, spherical polymers, have demonstrated their utility as drug and imaging agent delivery vehicles for use in detecting and treating cancer, with several dendrimer-based agents nearing human clinical trials.

29 Jan 2007

Design of gold nanoparticles for magnetic resonance imaging

Molecular complexes containing the element gadolinium are proven agents for increasing the diagnostic utility of magnetic resonance imaging (MRI), but their use in detecting small tumors is limited by the relatively weak signal these agents produce.

29 Jan 2007

Polymer nanoparticles for immunotherapy from encapsulated tumor-associated antigens and whole tumor cells

Using a biodegradable nanoparticle as a means of delivering tumor cell debris and proteins to the immune system, investigators at Yale University have developed a promising new method for creating therapeutic anticancer vaccines.

29 Jan 2007

Healthcare Research and Development Institute reaches settlement with two State Attorneys General over alleged anticompetitive practices

The Florida-based Healthcare Research and Development Institute, a consulting group owned by about three dozen hospital executives, has agreed to no longer accept fees from companies that sell medications, medical devices and financial services to not-for-profit hospitals nationwide, according to a settlement reached on Wednesday with the Connecticut and Florida attorneys general, the New York Times reports.

29 Jan 2007

New drug to treat kidney failure during septic shock

Research from Melbourne's Howard Florey Institute and the Austin Hospital has resulted in a drug to treat kidney failure during septic shock, which will be trialled at the Austin Hospital from mid-2007.

29 Jan 2007

China should own up to past HIV/AIDS mistakes

Although China in recent years "has made bold strides in its response to HIV/AIDS," the number of new HIV/AIDS cases will continue to increase unless the country "owns up to past mistakes, encourages and supports civil society involvement, and proactively deals with the serious challenges of stigma and misinformation".

29 Jan 2007

HIV/AIDS advocates call on Zimbabwe to address broad health care issues

Although some HIV/AIDS advocates in Zimbabwe are welcoming a recent pledge from the Zimbabwean government to provide increased access to antiretroviral drugs by the end of this year, they also are stressing the need to address a broader crisis in the country's health care system, VOA News reports.

29 Jan 2007

Greater Boston Interfaith Organization urges delay in penalties against uninsured

The Greater Boston Interfaith Organization on Wednesday asked state officials to delay for one year a provision of the Massachusetts health insurance law that will penalize residents who do not obtain insurance by July 1, the Boston Globe reports.

29 Jan 2007

Sequenom and Lenetix to develop Rhesus D prenatal diagnostic

Sequenom, Inc. and Lenetix Medical Screening Laboratory, Inc., a provider of rapid genetic screening and diagnostic testing for clinicians worldwide, today announced that they have entered into a collaboration and license agreement to develop and commercialize a proprietary non-invasive prenatal Rhesus D (RhD) incompatibility test based on Sequenom patent rights and RT PCR methodology.

29 Jan 2007

FoxOs shown to be potential new targets for cancer drugs

In an elegant, multiple-gene knockout experiment, a team of Boston scientists has discovered that a trio of molecules, called FoxOs, are fundamentally critical in preventing some cancers, maintaining blood vessel stability, and in keeping blood-forming stem cells healthy.

29 Jan 2007

Potential protection against failed back surgery syndrome

Texas researchers believe that they have discovered how to prevent many cases of the most common problem encountered by patients undergoing spine surgery: failed back surgery syndrome (FBSS).

29 Jan 2007