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The efficacy and safety of Rituximab in patients with active rheumatoid arthritis

Drugs aimed at suppressing inflammation-provoking cytokines--specifically those linked to T-cells--have improved the treatment of rheumatoid arthritis (RA), a chronic, inflammatory autoimmune disease. Still, the frequency of remission achieved by these biologic agents remains below 50 percent.

3 May 2006

Researchers have made important progress in regenerating hearing cells

Massachusetts General Hospital (MGH) researchers have made important progress in their ongoing effort to regenerate the inner ear's hair cells, which convert sound vibrations to nerve impulses.

3 May 2006

Pediatricians encouraged to refer patients to community resources for childhood aggression

Training pediatricians to recognize the signs of aggression and make a referral to an appropriate community organization may help prevent future violence.

3 May 2006

MRI clues identify stroke victims at risk of skull hemorrhaging

The appearance of parenchymal enhancement of stroke lesions and the hyperintense MCA sign on MRI may help identify stroke patients at risk of hemorrhaging in the skull, says a new study by researchers at Shantou University Medical College in China and the University of Toronto in Canada.

3 May 2006

Image-guided kidney biopsy can diagnose benign kidney tumors and has a low rate of complications

For the study, 407 image-guided kidney lesion biopsies were performed in 377 patients using either CT, ultrasound, or a combination of both to guide a small needle through the skin of the patient to take a sample of the lesion.

3 May 2006

Pten regulates neuronal arborization and social interaction in mice

While the causes of autism remain complex and mysterious, researchers are steadily adding pieces to its intricate puzzle. In what they believe to be a significant new approach to understanding "autism spectrum disorders" (ASD), researchers have developed a mouse that shows abnormal social interactions and brain hypertrophy characteristic of the disease.

3 May 2006

Reward-motivated learning: mesolimbic activation precedes memory formation

The prospect of a paycheck, good grade, or promotion wonderfully concentrates the mind, and researchers have now identified the brain circuitry responsible for such reward-motivated learning.

3 May 2006

New technique for freezing and preserving genetically enhanced pig embryos

Researchers led by a University of Missouri-Columbia professor of reproductive biotechnology have reported success in freezing and preserving swine embryos that were created by in vitro techniques and that carried modified genetic material.

3 May 2006

Researchers pinpoint autism's genetic roots

By deleting a gene in certain parts of the brain, researchers at UT Southwestern Medical Center have created mice that show deficits in social interaction that are reminiscent of humans with autism spectrum disorders.

3 May 2006

Bladeless LASIK as good as standard microkeratome LASIK

A Mayo Clinic study comparing femtosecond (bladeless) and mechanical microkeratome LASIK surgeries has found equal results from both types six months post-surgery, using a variety of vision and eye health measurements.

3 May 2006

If jaundice is detected and treated properly children at no greater risk

Newborn babies who are diagnosed with and treated for jaundice are no more likely than other babies to suffer long-term developmental problems, according to a study published in the New England Journal of Medicine.

3 May 2006

Gay men who are HIV-positive rarely regret revealing their health status to others

The study, the first of its kind, could be important for clinicians who work with HIV-positive men who are often uncertain whether to tell friends, family, co-workers or others about being diagnosed with the virus that causes AIDS.

3 May 2006

Combination of genetic mutation and viral infection may cause prostate cancer

Significant recent interest in the literature (JAMA 2006;295:1503, Lancet, epub) and by patients has arisen in response to a presentation given by Dr. Eric Klein of the Cleveland Clinic at the 2006 Prostate Cancer Symposium in San Francisco, February 24, 2006.

3 May 2006

Cancer survivors in Norway have normal living conditions

In the context of sociological research, cancer patients' quality of life and living conditions constitute their welfare.

3 May 2006

A new fast-melting oral formulation of desmopressin

Vande Walle and colleagues performed this study to determine the pharmacodynamic properties as well as the safety and tolerability of a new oral lyophilisate formulation of desmopressin (in single doses of 30, 60, 120, 240, 360 or 480 µg) in children with known primary nocturnal enuresis (PNE).

3 May 2006

Inhibiting cell process may give cancer drug a boost

A molecule that interferes with the internal scaffolding that shapes the cell may kill cancer cells, retard the growth of tumors and give a boost to a common chemotherapy drug, according to findings appearing in the May 3 issue of the European Journal of Cancer.

3 May 2006