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Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Modern research is delving deep into the human genome to find the answers to medical mysteries and, hopefully, cures for the most deadly diseases. According to four new studies presented during the 46th Annual Meeting of the American Society of Hematology

5 Dec 2004

Researchers step closer to cure for common childhood cancer

Acute lymphoblastic leukemia (ALL) is a malignant disease caused by the abnormal growth and development of white blood cells (WBC) in the bone marrow and blood. ALL is the most common cancer occurring in children with an annual rate of approximately 30 to 40 new cases per million.

5 Dec 2004

Hydroxyurea plus aspirin best therapy in patients with essential thrombocythemia who are at high risk for vascular events

A new treatment for an incurable blood disorder proves a worse option for patients' health than an older treatment, according to a study to be presented today during the 46th Annual Meeting of the American Society of Hematology (ASH).

5 Dec 2004

Genetic target found for pediatric leukemia

A molecular target newly discovered by scientists at two prestigious research institutes may pave the way for new treatments that could combat an aggressive form of leukemia, according to a study to be presented today during the 46th Annual Meeting of the American Society of Hematology (ASH).

5 Dec 2004

Positive results from phase 2 trial of Telintra, drug candidate in myelodysplastic syndrome

Telik, Inc. reported positive interim data from a Phase 2 trial of its Telintra (TLK199) drug candidate in myelodysplastic syndrome (MDS). The data were reported in two presentations at the annual meeting of the American Society of Hematology in San Diego.

5 Dec 2004

Bcl-6 oncogene - genetic target for lymphoma treatment

Results from a pre-clinical study show that the gene designated Bcl-6 is an oncogene -- that is, one with the potential to cause a normal cell to become cancerous -- but that certain peptide inhibitors can in effect inactivate it, according to a study to be presented today during the 46th Annual Meeting of the American Society of Hematology (ASH).

5 Dec 2004

A new treatment for patients with chronic myeloid leukemia

A new treatment for patients with chronic myeloid leukemia (CML) -- a disorder marked by an overproduction of white blood cells -- yields positive results in those who have relapsed on imatinib, the standard treatment for the disease, according to a Phase I study to be presented today at the 46th Annual Meeting of the American Society of Hematology (ASH).

5 Dec 2004

Genasense shown to enhance the anti-lymphoma activity of Velcade and Rituxan

Genta Incorporated announced that two new studies have shown that Genasense (oblimersen sodium) Injection, the Company's lead anticancer drug, showed synergistic activity with both bortezomib (Velcade; Millennium Pharmaceuticals, Inc.) and rituximab (Rituxan; Genentech, Idec) in experimental models of B-cell non-Hodgkin's lymphoma (NHL).

5 Dec 2004

Data from phase II study of Trisenox (arsenic trioxide) injection in myelodysplasia

At the 46th Annual Meeting of the American Society of Hematology (ASH) preliminary data were presented from a phase II study of Trisenox (arsenic trioxide) injection in myelodysplasia (MDS).

5 Dec 2004

Single dose phase I data on CG53135 for the prevention of oral mucositis

CuraGen Corporation has announced results presented from a Phase I clinical trial with CG53135 for the prevention of oral mucositis (OM) in patients receiving high dose chemotherapy (HDCT) followed by autologous hematopoietic stem cell transplantation (AHSCT) at the ASH 46th Annual Meeting in San Diego, CA.

5 Dec 2004

As mobile phone use rises, possibility of unseen biological impact is quietly troubling

Cell biologists are of two minds about the possible biological effects of mobile phone radiation. In the mid-1990s, studies describing possible pathological effects on tissues bombarded with low-level radio frequencies (RF) were first featured in the popular press and then discredited by scientists.

4 Dec 2004

Autophagy is also cell's second line of defense against invading pathogens such as strep

Cells give up their secrets slowly. Just when you think that all major cellular systems are understood, along comes a surprise. The latest is about autophagy, a major pathway for degrading and recycling within cells.

4 Dec 2004

Temperature sensing protein implicated in mediating thermotaxis

The songwriter Noel Coward once declared that only mad dogs and Englishmen went out in the midday sun. MIT biologists Mark Rosenzweig, Paul Garrity and their colleagues now have a third candidate for the lyric—fruit flies with defects in a gene called dTrpA1.

4 Dec 2004

A gallery of highly-specific, gene and protein “mug shots” of cancer types would be a powerful for oncologists

Doctors would like to diagnose malignancies rapidly by matching them with highly-specific genetic “mug shots” based on the presence of characteristic mRNAs or proteins. This kind of specificity would facilitate screening and early detection, and would potentially allow targeted treatments specific to each type of cancer

4 Dec 2004

New and revealing portrait of Yersinia pestis emerges

Yersinia pestis, the causative agent of the “Black Death” or “Bubonic” plague, has been a scourge of human civilization. One of the most virulent bacterial pathogens known, killing nearly 90% of those infected, Y. pestis was responsible for three historic pandemics that shattered whole societies.

4 Dec 2004

Oral targeted therapy shows benefit in treating high-risk myelodysplastic syndrome

An oral targeted therapy gentle enough to be used by patients in their 70s or 80s is showing benefit in treating high-risk myelodysplastic syndrome (MDS), a pre-leukemic disorder that can progress to acute myelogenous leukemia (AML)

4 Dec 2004

Implications of twin, triplet and quadruplet pregnancies on mothers

More women giving birth in their later years has given rise to fertility treatments which has in turn led to what can be described as an explosion in twin, triplets and quadruplet pregnancies.

4 Dec 2004

Herpes virus offers new hope in search for cure for cancer

In laboratory studies at Cincinnati Children's Hospital Medical Center, researchers have successfully treated the most common malignant abdominal tumor of childhood: neuroblastoma tumors.

4 Dec 2004

Botox may reduce the incidence of keloids, improving the appearance of scars

Can a modern-day drug cure an age-old healing disorder that causes more harm than the actual injury?

4 Dec 2004

Research raises question on shark cartilage use as an anti-cancer treatment

The rising popularity of shark cartilage extract as an anti-cancer treatment is a triumph of marketing and pseudoscience over reason, with a tragic fallout for both sharks and humans, according to a Johns Hopkins biologist writing in the Dec. 1 issue of Cancer Research.

4 Dec 2004

Medical News

Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Researchers step closer to cure for common childhood cancer

Hydroxyurea plus aspirin best therapy in patients with essential thrombocythemia who are at high risk for vascular events

Genetic target found for pediatric leukemia

Positive results from phase 2 trial of Telintra, drug candidate in myelodysplastic syndrome

Bcl-6 oncogene - genetic target for lymphoma treatment

A new treatment for patients with chronic myeloid leukemia

Genasense shown to enhance the anti-lymphoma activity of Velcade and Rituxan

Data from phase II study of Trisenox (arsenic trioxide) injection in myelodysplasia

Single dose phase I data on CG53135 for the prevention of oral mucositis

As mobile phone use rises, possibility of unseen biological impact is quietly troubling

Autophagy is also cell's second line of defense against invading pathogens such as strep

Temperature sensing protein implicated in mediating thermotaxis

A gallery of highly-specific, gene and protein “mug shots” of cancer types would be a powerful for oncologists

New and revealing portrait of Yersinia pestis emerges

Oral targeted therapy shows benefit in treating high-risk myelodysplastic syndrome

Implications of twin, triplet and quadruplet pregnancies on mothers

Herpes virus offers new hope in search for cure for cancer

Botox may reduce the incidence of keloids, improving the appearance of scars

Research raises question on shark cartilage use as an anti-cancer treatment

How does norepinephrine influence anxiety-related behaviours?

Transforming Lab Workflows with Cell Culture Automation

Building Bridges to Scalable Allogeneic Cell Therapy

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