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Why some lung cancers stop responding to the drugs erlotinib (Tarceva) and gefitinib (Iressa)

Researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) have found an explanation for why some lung cancers stop responding to the drugs erlotinib (Tarceva) and gefitinib (Iressa).

22 Feb 2005

First comprehensive examination of strenuous physical activity and the risk of developing Parkinson's disease

In the first comprehensive examination of strenuous physical activity and the risk of developing Parkinson's disease, researchers from the Harvard School of Public Health (HSPH) have found that men who exercised regularly and vigorously early in their adult life had a lower risk for developing Parkinson's disease compared to men who did not.

22 Feb 2005

Cell phones useful and feasible for visualizing leg wounds

Use of cell phones to send images via e-mail to consulting physicians at remote locations appears to be a feasible approach for visualization of chronic leg ulcerations, according to an article in the current issue of Archives of Dermatology.

21 Feb 2005

Obstructive sleep apnea syndrome in snorers

An overnight sleep test is required to distinguish ordinary snorers from persons with obstructive sleep apnea syndrome (OSAS), according to a study in the current issue of Archives of Otolaryngology - Head & Neck Surgery.

21 Feb 2005

Elderly patients can safely undergo gastric bypass surgery

Elderly patients can safely undergo gastric bypass surgery and can be expected to experience similar benefits from the operation as younger patients, according to background information in an article in the current issue of Archives of Surgery.

21 Feb 2005

Antimicrobials improperly used about 50% of the time

Antimicrobial medications intended to prevent surgical site infections are appropriately administered to patients (within one hour before incision) only 55.7 percent of the time, according to a study published in the February issue of Archives of Surgery.

21 Feb 2005

Three-day antibiotic treatment for treating bladder infections in women

A three-day regimen of the antibiotic amoxicillin-clavulanate is not as effective as ciprofloxacin at treating an uncomplicated bladder infection in women, according to a study conducted by Thomas M. Hooton, M.D., of the University of Washington and Harborview Medical Center, Seattle, and colleagues.

21 Feb 2005

Bipolar disorder a common feature in urban primary care practice

According to a study in the February 23 issue of JAMA. Nearly 10 percent of patients screened at a general medicine clinic in an urban area were found to have a history of bipolar disorder.

21 Feb 2005

Increased risk of urinary incontinence with hormone therapy

Menopausal hormone therapy (MHT), consisting of oral estrogen plus progestin or estrogen alone, considered in the past as treatment for urinary incontinenc, was until recently, credited with many benefits well beyond the indications for symptomatic relief of hot flashes, night sweats, and vaginal dryness. One of the benefits of MHT was to improve the symptoms of urinary incontinence (UI), and it has often been prescribed to treat UI.

21 Feb 2005

82 percent of women have at least one factor that puts them at risk for a future heart attack

In the second year of a Northern California-based survey conducted by Sutter Health on women and heart disease, results show that more women are aware of heart attack warning signs and the need to take action quickly.

21 Feb 2005

Stop-smoking products increase quit rate for smokers who need to quit the most

An article in the current issue of the Journal of Substance Abuse Treatment (Volume 28, Issue 1, 2005) provides new hope for smokers who are highly dependent upon tobacco and who smoke more than two packs per day.

21 Feb 2005

New compound, AMN107, 20 times more potent than Gleevec for chronic myelogenous leukemia treatment

A laboratory study led by researchers at Dana-Farber Cancer Institute has shown that a potent and highly selective therapy for chronic myelogenous leukemia (CML) may ultimately be more effective than Gleevec®, the current standard of care.

21 Feb 2005

Female sex hormones have a profound effect on susceptibility to the herpes simplex virus

Two McMaster University studies, to be published in the Journal of Virology, show that sex hormones have a profound effect on susceptibility of female mice to the herpes simplex virus, type 2 (HSV-2 ), one of the most common sexually transmitted diseases.

21 Feb 2005

Crystallized molecular machine reveals possible new paths for treating diseases

The crystallized form of a molecular machine that can cut and paste genetic material is revealing possible new paths for treating diseases such as some forms of cancer and opportunistic infections that plague HIV patients.

21 Feb 2005

Good Behavior Game dramatically reduced aggressive behavior and helped children stay on task in the classroom

When Laura Bush visited an inner city Baltimore classroom earlier this month, she observed first-grade students playing a game that promotes good behavior as they worked on a reading assignment. The First lady’s words of praise for the “Good Behavior Game” shined the national spotlight on a classroom management technique little known outside academic circles.

21 Feb 2005

New clues to amyloidoses

Familial amyloid polyneuropathy (FAP), a hereditary disease characterised by abnormal deposits of insoluble protein in the organs, results from a mutation in a single gene (the transthyretin or TTR gene). Nevertheless, disease incidence and age of onset can vary significantly between patients what have always puzzled scientists.

21 Feb 2005

New findings on the regulation of cellular growth

A greatly increased synthesis of new proteins is one of the first and most important events that occur in both normal and tumour cells upon growth stimulation.

21 Feb 2005

Lack of collagen increases likelihood of osteoarthritis

Duke University Medical Center researchers have found that joints whose cartilage lacks a specific type of collagen will develop osteoarthritis – the so-called "wear-and-tear" form of the disease – at a greatly accelerated rate.

20 Feb 2005

Young adults can be motivated to eat more servings of fruits and vegetables

Young adults can be motivated to eat more servings of fruits and vegetables if they are exposed to tailored, practical messages about nutrition, a University of Wisconsin-Madison nutritional scientist announced at the annual meeting of the American Association for the Advancement of Science (AAAS) in Washington, D.C.

20 Feb 2005

Exercise and dietary changes vital in taking and keeping off weight that is associated with many chronic health problems

When the National Academy of Science’s Institute of Medicine recently announced that Americans should exercise an hour a day to fight the country’s growing obesity epidemic, collective groans could be heard in big cities and small towns everywhere.

20 Feb 2005