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Less than half of approved new drugs add substantial therapeutic value over existing treatments

New drugs are often used not only for one disease (first approved indication) but also for other diseases (supplemental indications).

5 Jul 2023

Researchers develop dissolving cardiac device to monitor and treat heart disease

Nearly 700,000 people in the United States die from heart disease every year, and one-third of those deaths result from complications in the first weeks or months following a traumatic heart-related event.

5 Jul 2023

Study: BMI may not increase mortality independently of other risk factors

Body mass index (BMI) may not increase mortality independently of other risk factors in adults, according to a new study published this week in the open-access journal PLOS ONE by Aayush Visaria and Soko Setoguchi of Rutgers University, US.

5 Jul 2023

Study sheds light on the long-term effects of COVID-19 on minority groups

A new study conducted by researchers at Bar-Ilan University in Israel has shed light on the long-term impact of COVID-19 on the quality of life among different ethnic groups in the country. The study, part of a larger cohort project, highlights a significant discrepancy between Arabs and Druze, and Jews, with the two former groups experiencing a more pronounced decline in quality of life one year after infection.

5 Jul 2023

Medical cannabis laws have no effect on opioid prescriptions, study finds

State laws allowing medical cannabis use did not reduce prescriptions for opioids or other therapies for chronic, non-cancer pain, according to a policy analysis by Weill Cornell Medicine investigators.

5 Jul 2023

Regular cannabis users more likely to experience postoperative complications, study finds

People who are regular cannabis users are at an increased risk of experiencing complications before, during, and after surgery, according to a study by researchers with UTHealth Houston published today in JAMA Surgery.

5 Jul 2023

New blood test could diagnose bile acid diarrhea

Most people have at some point in their life suffered an intestinal infection or food poisoning forcing them to stay close to the bathroom. It is very uncomfortable. Most of the time, though, it passes quickly.

5 Jul 2023

Study reveals how a person remembers experiences of childhood abuse or neglect can impact future emotional disorders

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London and City University New York, published today (Wednesday 5 July) in JAMA Psychiatry, has found that the way childhood abuse and/or neglect is remembered and processed has a greater impact on later mental health than the experience itself.

5 Jul 2023

Study sheds light on cause of most common congenital heart defect

Bicuspid aortic valve is the most common congenital defect in humans, affecting between 1% and 2% of the population. Instead of the usual three symmetric leaflets, affected individuals have two asymmetric valve leaflets.

5 Jul 2023

Hospitalized Kenyan patients more likely to harbor antibiotic-resistant bacteria

Kenyan patients who spend more than three days in the nation's hospitals are more likely to harbor a form of bacteria resistant to one of the most widely used antibiotic classes, according to a recent study led by Washington State University.

5 Jul 2023

Using a vaccine to boost the response of engineered T cells

Engineering T cells to destroy cancer cells has shown success in treating some types of cancer, such as leukemia and lymphoma. However, it hasn't worked as well for solid tumors.

5 Jul 2023

Danish researchers solve puzzle of how hepatitis C virus evades immune system

With a new method for examining virus samples researchers from the University of Copenhagen have solved an old riddle about how Hepatitis C virus avoids the human body's immune defenses.

5 Jul 2023

Candidate genes for inflammatory bowel disease identified

A study of the genetic variation that makes mice more susceptible to bowel inflammation after a high-fat diet has identified candidate genes which may drive inflammatory bowel disease (IBD) in humans. The findings are published as a Reviewed Preprint in eLife.

5 Jul 2023

Study shows how glutamine can help or hinder cancer-killing activity

Scientists at St. Jude Children's Research Hospital found immune and tumor cells compete over glutamine, a major nutrient in their local environment, with significant implications for anti-cancer activity.

5 Jul 2023

Researchers uncover the role of glutaminase 2 in glucose homeostasis

Glutaminase 2 (GLS2) is a master regulator of glutaminolysis. GLS2 converts glutamine to glutamate, thereby playing a role in cellular energy production. GLS2 is abundant in the liver, and is also found in pancreatic β-cells. However, the role of GLS2 in pancreatic islets – in which both ɑ- and β- cells are present – associated with glucose metabolism is currently unknown.

5 Jul 2023

Biomarker found in urine could help diagnose acute tubulointerstitial nephritis

In a study led by Johns Hopkins Medicine, in collaboration with Yale School of Medicine, researchers have identified a biomarker found via a simple urine test that can be used to diagnose acute tubulointerstitial nephritis (AIN), a medical condition that causes inflammation of the kidneys and can lead to acute kidney injury (AKI) — a sudden loss of kidney function.

5 Jul 2023

Study examines how B cells affect the development of PCOS

Polycystic ovary syndrome (PCOS) is a common hormone disorder in women. Studies have shown that the change in hormones is accompanied by variations in immunological B cells.

5 Jul 2023

Ever-growing global diabetes burden exacerbated by large-scale inequity

Despite increased awareness and ongoing multinational efforts, diabetes is pervasive, exponentially growing in prevalence, and outpacing most diseases globally, according to a new Series published in The Lancet and The Lancet Diabetes & Endocrinology journals.

5 Jul 2023

New study to evaluate bleeding complications in patients undergoing high-risk PCI with Impella

A new multicenter, single-arm, open-label study is the first to exclusively assess bleeding complications in patients undergoing high-risk percutaneous coronary interventions (PCI) with Impella with independent adjudication via a clinical events adjudication committee and will gather meaningful real-world data based on contemporary practice.

5 Jul 2023

Clinical trial of three-month TB treatment regimen closed due to high rate of unfavorable outcomes

The first clinical trial of a three-month tuberculosis (TB) treatment regimen is closing enrollment because of a high rate of unfavorable outcomes with the investigational course of treatment.

5 Jul 2023