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African bacterium resists almost all drugs

It looks like it’s time to pay the piper. The first extensively drug-resistant (XDR) strain of Salmonella typhimurium, called ST313 sublineage II.1, has cropped up in the Democratic Republic of Congo (DRC). This fails to respond to any of the antibiotics that are commonly used in the DRC, except for ciprofloxacin. And to make things worse, one sample has been isolated that shows incomplete response even to this last drug.

22 Sep 2019

Faster, cheaper, better: improved gene therapy tool production

The heart of modern therapy is increasingly personalized and targeted at specific cellular or genetic deficits. This requires gene therapy, in many cases. A new study, published on 19 September 2019 in the journal Nature, describes an improved way to produce purified gene carrier viruses called AAVs cheaply and quickly, from the culture medium.

22 Sep 2019

New study identifies potential enzyme target for diabetic retinopathy

A new study shows that diabetic retinopathy (DR), or retinal disease caused by the high blood glucose levels in diabetes mellitus, is due to the death of retinal cells because of the high levels of a pro-enzyme called lysyl oxidase propeptide (LOX-PP). This could help researchers develop specific treatments by targeting this molecule.

22 Sep 2019

RNA hitches lysosome rides to make proteins far away from the nucleus

Proteins inside a cell are often made at the site where they are used, rather than being shipped long distances. This is so with nerve cells which have long cell extensions in the form of axons and dendrites, up to four feet long in some case

22 Sep 2019

Identification and management of depression in people with epilepsy to save lives

Depression is the most common psychiatric comorbidity in people with epilepsy. Clinical studies have found that 20% to 30% of people with epilepsy have depression; the incidence may be as high as 50% to 55% in people visiting hospital epilepsy centers.

21 Sep 2019

UTHealth's innovative cancer-fighting projects receive $11 million CPRIT funding

Five innovative cancer-fighting projects at The University of Texas Health Science Center at Houston received just over $11 million during the latest round of grants awarded by the Cancer Prevention and Research Institute of Texas

21 Sep 2019

Leukemia drug appears to be effective in treating deadly pediatric brain tumor

A drug used to treat chronic myeloid leukemia appears to be more effective at stopping a type of medulloblastoma in mouse models than existing treatments for the deadly pediatric brain tumor, reports a multi-institutional team led by researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego.

21 Sep 2019

Advancements in pain management are giving new options to patients

Hardly a day goes by without the public being warned about the dangers of opioids. But still, according to the National Institute on Drug Abuse, more than 130 people die every day of opioid overdose and the problem is getting worse.

21 Sep 2019

Researchers aim to explore effects of age, gender on brain injury mechanics

Traumatic brain injury and chronic traumatic encephalopathy have become common in athletes who suffer repeated blows to the head. Most recently, former New England Patriots tight end Rob Gronkowski revealed that he had sustained about 20 concussions during his nine-year career in the National Football League.

21 Sep 2019

Cutting-edge technologies to improve drug development while reducing animal testing

On Thursday, September 19th, 2019, the Physicians Committee for Responsible Medicine hosted a congressional briefing in cooperation with Rep. Brendan Boyle (D-Pa.), featuring innovator companies showcasing cutting-edge technologies that have the potential to improve the safety and efficacy of pharmaceuticals while reducing animal testing.

20 Sep 2019

Open Medicare data provides critical insights on hidden costs of health care

An interdisciplinary team of Indiana University scientists studying Medicare data have found an association between health care industry payments to medical providers for non-research expenses and what these providers charge for medical services -- shedding new light on potential hidden costs to the public.

20 Sep 2019

New clinical trial tests immunotherapy drug for prostate cancer patients on active surveillance

Stephenson Cancer Center Testing Drug for Prostate Cancer Patients on Active Surveillance OKLAHOMA CITY - Men who are diagnosed with low-risk prostate cancer usually opt for active surveillance - a monitoring of their cancer over time without undergoing treatments that would cause side effects.

20 Sep 2019

Pembrolizumab provides added benefit for subpopulations of patients with metastatic NSCLC

In early July, the German Institute for Quality and Efficiency in Health Care conducted two early benefit assessments to investigate whether certain drug combinations with pembrolizumab have advantages in comparison with the respective appropriate comparator therapy for patients with metastatic squamous or non-squamous non-small cell lung cancer.

20 Sep 2019

C-Path and NORD launch new platform to accelerate drug development for rare diseases

The Critical Path Institute and the National Organization for Rare Disorders® launched the Rare Disease Cures Accelerator-Data and Analytics Platform in Rockville, MD on Tuesday, Sept. 17.

20 Sep 2019

Mutations in specific protein make dengue virus resistant to vaccines and therapeutics

Dengue virus infects about 400 million people annually around the world, with a high prevalence in tropical and sub-tropical regions.

20 Sep 2019

SCAI's new shock classification scheme used to analyze patients in cardiac intensive care unit

A new shock classification scheme released by the Society for Cardiovascular Angiography and Interventions and endorsed by the American College of Cardiology, American Heart Association, the Society of Critical Care Medicine and the Society of Thoracic Surgeons was recently applied in a retrospective study analyzing patients in the cardiac intensive care unit at the Mayo Clinic.

20 Sep 2019

Novel gene therapy for glycogen storage disease shows positive results

At the Association for Glycogen Storage Disease's 41st Annual Conference, Dr. David Weinstein of UConn School of Medicine and Connecticut Children's presented his groundbreaking, one-year clinical trial results for the novel gene therapy treatment for glycogen storage disease.

20 Sep 2019

Medical News

African bacterium resists almost all drugs

Faster, cheaper, better: improved gene therapy tool production

New study identifies potential enzyme target for diabetic retinopathy

RNA hitches lysosome rides to make proteins far away from the nucleus

Identification and management of depression in people with epilepsy to save lives

UTHealth's innovative cancer-fighting projects receive $11 million CPRIT funding

Leukemia drug appears to be effective in treating deadly pediatric brain tumor

Advancements in pain management are giving new options to patients

Researchers aim to explore effects of age, gender on brain injury mechanics

Cutting-edge technologies to improve drug development while reducing animal testing

Open Medicare data provides critical insights on hidden costs of health care

New clinical trial tests immunotherapy drug for prostate cancer patients on active surveillance

Pembrolizumab provides added benefit for subpopulations of patients with metastatic NSCLC

C-Path and NORD launch new platform to accelerate drug development for rare diseases

Mutations in specific protein make dengue virus resistant to vaccines and therapeutics

SCAI's new shock classification scheme used to analyze patients in cardiac intensive care unit

Novel gene therapy for glycogen storage disease shows positive results

Study confirms lasting impact of neonatal CPAP technology in Malawi

Undocumented immigrants have comparable transplant survival rates to U.S. citizens

Penn researchers develop novel vaccine to protect against genital herpes

Directed enzyme evolution and the Nobel Prize: Making enzymes evolve in the lab

Advancing Motor Neuron Disease Diagnosis with Non-Invasive Ultrasound and AI

How agentic AI is reshaping laboratory workflows

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