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Myc cancer gene allows tumor cells to divide, provokes cell suicide process

Myc cancer gene empowers tumor cells to relentlessly divide but simultaneously, provokes a cell suicide process called apoptosis. Myc controls cells by commanding the expression of every tenth of the genes in the nucleus of a tumor cell. However, in spite of more than two decades of intense research, no Myc motivated killer genes have been found.

21 Apr 2015

Designing AR Inhibitors Team wins AACR Team Science Award for developing prostate cancer treatment

The American Association for Cancer Research will award the ninth annual AACR Team Science Award to the Designing Androgen Receptor (AR) Inhibitors Team from Memorial Sloan Kettering Cancer Center and the University of California, Los Angeles at the AACR Annual Meeting 2015, to be held in Philadelphia, April 18-22.

21 Apr 2015

Experimental immune therapy generally safe, well-tolerated in women with triple-negative breast cancer

Early data in a preliminary human study show that an experimental immune system drug is generally safe and well tolerated in women with metastatic, triple-negative breast cancer, a persistently difficult form of the disease to treat.

21 Apr 2015

Mott poll measures public's views about use of medical marijuana for children

Medical marijuana and children don't mix, most Americans say. While nearly two-thirds of people agree that their state should allow medical marijuana for adults, half as many - just over a third - say it should be allowed for children, according to today's University of Michigan C.S. Mott Children's Hospital National Poll on Children's Health that included a national sample of adults in the U.S.

21 Apr 2015

New UM SOM study reveals why thiazide drugs not effective in some patients

Every year, more than 120 million prescriptions are written worldwide for thiazide drugs, a group of salt-lowering medicines used to treat high blood pressure. These drugs are often work very well, and over decades have saved hundreds of thousands of lives.

21 Apr 2015

Targeting PD-1/PD-L1 signaling may open up new therapy options for lung cancer patients

New findings about regulation of PD-L1, a protein that allows cancer to evade the immune system, has shown therapeutic promise for several cancers, including the most common form of lung cancer.

21 Apr 2015

Two new research papers reveal how breast cancer cells avoid anoikis

Two new papers from the lab of Zach Schafer, Coleman Assistant Professor of Cancer Biology at the University of Notre Dame, offer insights into how breast cancer cells avoid anoikis, which is cell death induced by detachment from the extracellular matrix (ECM).

21 Apr 2015

New OCT angiography can improve clinical management of leading causes of blindness

Research published today in the Proceedings of the National Academy of Sciences demonstrates that technology invented by researchers at Oregon Health & Science University's Casey Eye Institute can improve the clinical management of the leading causes of blindness.

21 Apr 2015

CML guidelines highlight need for TKI switch timing, choice

A review of the European LeukemiaNet guidelines on the care of patients with chronic myeloid leukaemia highlights the need for research into the timing and use of second-line and third-line tyrosine kinase inhibitors.

20 Apr 2015

Novel treatment strategy targets treatment-resistant CML

Researchers have shown that the coiled-coil mimetic CCmut3 can inhibit cell growth and promote apoptosis in cell lines expressing BCR–ABL1, including those resistant to tyrosine kinase inhibitors.

20 Apr 2015

$HSCT increases fracture risk$

HSCT increases fracture risk

Fracture incidence is greatly increased in individuals who undergo haematopoietic stem cell transplantation compared with the general US population, research shows.

20 Apr 2015

Spirox closes $18.5 million Series B round of financing

Spirox Inc., a privately held medical device company, announced today the closing of an $18.5 million Series B round of financing led by Venrock and Aisling Capital. Existing investors Aperture Venture Partners, Correlation Ventures and Western Technology Investment also participated in the round.

20 Apr 2015

MGH researchers find probable mechanism associated with risk of developing serious diseases

Massachusetts General Hospital investigators have found the probable mechanism underlying a previously described biomarker associated with the risk of developing serious diseases ranging from cancer to cardiovascular disease and the risk of serious complications. In a paper published in the American Journal of Hematology, the research team reports finding that higher levels of a measure routinely taken as part of the complete blood count - the extent of variation in the size of red blood cells - is caused by reduced clearance of aging cells from the bloodstream.

20 Apr 2015

Two existing drugs may potentially become new drug target for multiple sclerosis

Two drugs already on the market -- an antifungal and a steroid -- may potentially take on new roles as treatments for multiple sclerosis. According to a study published in Nature today, researchers discovered that these drugs may activate stem cells in the brain to stimulate myelin producing cells and repair white matter, which is damaged in multiple sclerosis.

20 Apr 2015

UAS therapy for OSA recognized with a Top 10 Clinical Research Achievement Award

Inspire Medical Systems, Inc., announced today that a scientific paper on its Inspire Upper Airway Stimulation (UAS) therapy for obstructive sleep apnea (OSA), has been recognized with a Top 10 Clinical Research Achievement Award from the Clinical Research Forum.

20 Apr 2015

Ibrutinib (IMBRUVICA) may be effective for pancreatic ductal adenocarcinoma

Ibrutinib (IMBRUVICA) data presented yesterday by Pharmacyclics, Inc. at the American Association for Cancer Research Annual Meeting suggest that ibrutinib may be an effective therapeutic option for pancreatic ductal adenocarcinoma (PDAC), as shown in both a transgenic mouse model and an in-vivo model of patient-derived xenograft (PDX) mice (grafts of tissue taken from a pancreatic cancer patient and grafted into a mouse).

20 Apr 2015

Lupin introduces first Brand product Zaxine in Canada

Pharma Major Lupin Limited announced today that its Canadian subsidiary, Lupin Pharma Canada Limited (collectively Lupin) has launched its first Brand product Zaxine under a strategic licensing agreement with the North Carolina based GI specialty company Salix Pharmaceuticals Inc.

20 Apr 2015

Tandem Diabetes Care commences shipments of t:slim Insulin Pumps with enhanced software

Tandem Diabetes Care, Inc., a medical device company and manufacturer of the t:slim and t:flex Insulin Pumps, today commenced shipments of t:slim Pumps featuring enhanced software.

20 Apr 2015

University of Washington receives PPMD grant to continue analysis of spectrin-like repeats in dystrophin

Parent Project Muscular Dystrophy, a nonprofit organization leading the fight to end Duchenne muscular dystrophy (Duchenne) awarded University of Washington a $148,000 grant to continue the functional analysis of spectrin-like repeats in dystrophin.

20 Apr 2015

Tackling the challenge of managing fatigue in MS patients

Fatigue is one of the most commonly reported and debilitating symptoms of multiple sclerosis (MS) and can significantly reduce an individual's quality of life. Unlike the tiredness that we all experience sometimes, fatigue in those with MS can have a hugely negative impact - it can limit or stop people from doing day-to-day activities and things that really matter to them.

20 Apr 2015

Medical News

Myc cancer gene allows tumor cells to divide, provokes cell suicide process

Designing AR Inhibitors Team wins AACR Team Science Award for developing prostate cancer treatment

Experimental immune therapy generally safe, well-tolerated in women with triple-negative breast cancer

Mott poll measures public's views about use of medical marijuana for children

New UM SOM study reveals why thiazide drugs not effective in some patients

Targeting PD-1/PD-L1 signaling may open up new therapy options for lung cancer patients

Two new research papers reveal how breast cancer cells avoid anoikis

New OCT angiography can improve clinical management of leading causes of blindness

CML guidelines highlight need for TKI switch timing, choice

Novel treatment strategy targets treatment-resistant CML

HSCT increases fracture risk

Spirox closes $18.5 million Series B round of financing

MGH researchers find probable mechanism associated with risk of developing serious diseases

Two existing drugs may potentially become new drug target for multiple sclerosis

UAS therapy for OSA recognized with a Top 10 Clinical Research Achievement Award

Ibrutinib (IMBRUVICA) may be effective for pancreatic ductal adenocarcinoma

Lupin introduces first Brand product Zaxine in Canada

Tandem Diabetes Care commences shipments of t:slim Insulin Pumps with enhanced software

University of Washington receives PPMD grant to continue analysis of spectrin-like repeats in dystrophin

Tackling the challenge of managing fatigue in MS patients

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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