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University of Illinois study could provide insight into protein-misfolding diseases

When a large protein unfolds in transit through a cell, it slows down and can get stuck in traffic. Using a specialized microscope -- a sort of cellular traffic camera -- University of Illinois chemists now can watch the way the unfolded protein diffuses.

10 Dec 2014

Drug proves effective at inhibiting growth of drug-resistant bacteria

A treatment pioneered at the University of Pittsburgh Center for Vaccine Research is far more effective than traditional antibiotics at inhibiting the growth of drug-resistant bacteria, including so-called "superbugs" resistant to almost all existing antibiotics, which plague hospitals and nursing homes.

10 Dec 2014

Bed nets alone are enough to protect against malaria, study suggests

The combined use of spraying insecticide inside homes and insecticide-treated bed nets is no better at protecting children against malaria than using bed nets alone, a study in The Gambia suggests. The findings, published in The Lancet, should encourage donors to invest their limited resources in additional bed nets, the more cost-effective solution to tackling malaria.

10 Dec 2014

Epizyme's PRMT5 inhibitor shows efficacy in pre-clinical models of mantle cell lymphoma

Epizyme, Inc., a clinical stage biopharmaceutical company creating innovative personalized therapeutics for patients with genetically defined cancers, announced today the results from a preclinical study showing in vitro and in vivo activity of its first-in-class PRMT5 inhibitor EPZ015666 in mantle cell lymphoma (MCL), an aggressive form of non-Hodgkin lymphoma (NHL).

10 Dec 2014

Epizyme presents EPZ-5676 Phase 1 trial results for acute leukemia at ASH 2014

Epizyme, Inc., a clinical stage biopharmaceutical company creating innovative personalized therapeutics for patients with genetically defined cancers, announced today the presentation of results from the company’s Phase 1 trial of EPZ-5676, a potent and selective inhibitor of the DOT1L histone methyltransferase (HMT).

10 Dec 2014

Scientists identify brain mechanism that drives our appetite for glucose-rich foods

Scientists have discovered a mechanism in the brain that may drive our appetite for foods rich in glucose and could lead to improved treatments for obesity.

10 Dec 2014

Molecular response criteria examined for CML

The limitations in determining molecular response in patients with chronic myeloid leukaemia treated with tyrosine kinase inhibitor therapy have been reviewed in Cancer.

9 Dec 2014

Clinical markers help identify PD patients with cholinergic deficits

Assessing patients for clinical markers of cholinergic system denervation is viable and can help identify suitable individuals for trials of new anticholinergic drugs, researchers believe.

9 Dec 2014

PAH markers identified among Chinese systemic sclerosis patients

A study of Chinese patients with systemic sclerosis has identified predictive markers for accompanying pulmonary arterial hypertension similar to those that have been identified in other ethnic groups.

9 Dec 2014

PD-1, PD-L1 differentially expressed in NSCLC

The expression of the immune checkpoint protein programmed death-1 receptor and its ligand varies according to tumour and patient characteristics in oncogene-addicted non-small-cell lung cancer, research indicates.

9 Dec 2014

Quitting cannabis use during manic episodes improves outcomes

A post-hoc analysis of data from a prospective European study reveals that patients with bipolar disorder who stop using cannabis during a manic or mixed episode have similar clinical and functional outcomes to those who have never used the drug.

9 Dec 2014

Cardiac monitoring foretells clinical deterioration in PAH

Monitoring right ventricular parameters can give advance warning of clinical deterioration in stable patients with idiopathic pulmonary arterial hypertension, research suggests.

9 Dec 2014

Ponatinib ‘superior’ to sequential second-generation TKI treatment in CML

Patients with chronic myelogenous leukaemia resistant or intolerant to at least one second-generation tyrosine kinase inhibitor have a higher probability of achieving a response to the third-generation TKI ponatinib than to a further second-generation TKI, research indicates.

9 Dec 2014

At-home test sniffs out prodromal Parkinson’s disease

An at-home olfactory test helps to identify people with an increased risk of having dopamine transporter imaging indicative of early Parkinson’s disease, show data from the Parkinson Associated Risk Syndrome study.

9 Dec 2014

Excess mortality in schizophrenia ‘not attributable to antipsychotics’

The relationship between antipsychotic use and mortality in people with schizophrenia shows a clear U-shape curve, with the highest risk of death seen in those with no antipsychotic exposure, a Swedish cohort study has found.

9 Dec 2014

Simple blood test could help to detect breast cancer early

It may be possible to develop a simple blood test that, by detecting changes in the zinc in our bodies, could help to diagnose breast cancer early.

9 Dec 2014

MOVENTIG (naloxegol) receives EC approval for treatment of opioid-induced constipation

Nektar Therapeutics reported partner AstraZeneca today announced that MOVENTIG (naloxegol) has been granted Marketing Authorisation by the European Commission for the treatment of opioid-induced constipation (OIC) in adult patients who have had an inadequate response to laxative(s).

9 Dec 2014

Rey Colon launches telemedicine platform to help healthcare providers meet rising medical needs

Aging Baby Boomers, increasing healthcare demands, introduction of compulsory medical insurance rules of the Affordable Care Act and shortage of doctors paint a grim situation for healthcare in America. The healthcare industry is struggling to cope with these challenges. Keeping this scenario in consideration, Rey Colon, former partner and Chief Marketing Officer of AmeriDoc, a national telemedicine service provider, recently launched MyTelemedicine.com to help healthcare providers meet rising medical needs.

9 Dec 2014

Latest version of iMedX Mobile app released for physicians

iMedX, a leading health information solutions company and a leader in medical documentation solutions, today announced that it released the next version of iMedX Mobile: an iOS app that enables highly secure, HIPAA-compliant medical documentation capture and access for physicians via iPhone or iPad anytime, anywhere. The solution is available in the Apple App store for free to physicians and other clinicians using iMedX documentation solutions.

9 Dec 2014

Focus Diagnostics' Simplexa Flu A/B & RSV Direct Kit receive FDA clearance

As the 2014-2015 flu season begins, Focus Diagnostics, the products business of Quest Diagnostics, today announced that its Simplexa Flu A/B & RSV Direct Kit has received FDA clearance for eight additional influenza strains. These strains may pose significant potential health risks and may be circulating this winter.

From Quest Diagnostics 9 Dec 2014