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Gene variant boosts ulcer susceptibility in NSAID users

A single nucleotide polymorphism in the cytochrome P450 2C gene cluster influences the risk for peptic ulcer disease in people taking non-steroidal anti-inflammatory drugs, a study reveals.

31 Jan 2013

Hypertensive pregnancies need rigorous follow up

Women who have hypertensive complications during pregnancy are at increased risk for developing chronic kidney disease and end-stage renal disease, shows a study in the Canadian Medical Association Journal.

31 Jan 2013

Language processing deficits may occur at stuttering onset

A study of preschool-age children has shown key differences in the neural networks mediating language processing between those who stutter and those who do not.

31 Jan 2013

Mood disorder clinics improve bipolar disorder outcomes

Early treatment of patients with bipolar disorder in a specialized mood disorder clinic substantially reduces the risk for readmission to a psychiatric hospital, clinical trial findings show.

31 Jan 2013

Viscosupplementation may relieve subtalar osteoarthritis

Research suggests that patients with advanced subtalar osteoarthritis may benefit from intra-articular viscosupplementation.

31 Jan 2013

Palliative care for stroke affected by age, gender, stroke type

Whether patients with stroke are referred to palliative care services depends on their age, their gender, and what type of stroke they have had, Australian study results indicate.

31 Jan 2013

Bispectral index benefits for postoperative recovery unclear

A secondary analysis of two large clinical trials fails to settle the question of whether use of the bispectral index rather than end-tidal anesthetic concentration to monitor general anesthesia results in faster patient recovery.

31 Jan 2013

Strong placebo response key to adolescent migraine trial failures

A strong response to placebo is the main reason drug trials in the treatment of adolescent migraine have so far failed, say researchers.

31 Jan 2013

Dual renin angiotensin system blockade: too many cons

Any benefit of dual blockade of the renin angiotensin system is limited to its effects on surrogate endpoints, and outweighed by an excessive risk for adverse events such as hypotension, hyperkalemia, and renal failure, argue hypertension experts.

31 Jan 2013

Hyperconnectivity in brain emotion regions even in remitted bipolar I disorder

Bipolar I disorder patients who are in remission display increased coupling between brain regions involved in regulating emotions, even in the absence of a psychological task, shows a US study.

31 Jan 2013

Acute schizophrenia shows increased NMDA-R antibody prevalence

Patients with acute schizophrenia have an increased prevalence of N-methyl-D-aspartate glutamate receptor antibodies that is distinct from that seen in NMDA-R encephalitis, scientists have found.

31 Jan 2013

Bilateral and multiple ‘popping’ characterizes upper cervical HVLA

Cavitation during upper cervical high-velocity, low amplitude thrust manipulation is significantly more likely to occur bilaterally than unilaterally, say investigators.

31 Jan 2013

New insight into eczema’s itch

Research shows that innate lymphoid cells accumulate in active eczema lesions and may contribute to disease progression.

31 Jan 2013

Waist size trumps BMI as Barrett’s esophagus risk factor

Researchers have found that waist circumference independently predicts the risk for Barrett’s esophagus, leading them to dismiss a previously reported association between body mass index and the disease.

31 Jan 2013

Interferon retreatment of chronic hepatitis C may be harmful

People with hepatitis C and chronic liver disease who relapsed or failed to respond to initial treatment are unlikely to improve on interferon retreatment. In fact, they may face an increased risk of dying sooner, and are likely to experience a variety of adverse effects, according to an updated systematic review published in The Cochrane Library.

31 Jan 2013

TB test offers rapid detection of TB and drug-resistant strains according to new study

A diagnostic test for tuberculosis (TB) can accurately and quickly detect both TB and drug-resistant strains, according to a new study. The authors of a new systematic review assessing the diagnostic accuracy of the Xpert® MTB/RIF test published in The Cochrane Library say their study can provide timely advice for clinicians and policymakers in countries where TB is a major public health problem.

31 Jan 2013

Selenium supplements do not reduce risk of developing heart disease according to current evidence

A systematic review published today in The Cochrane Library finds that in well-nourished adults current evidence does not support selenium for preventing heart disease.

31 Jan 2013

Cerebrolysin: a promising new treatment for dementia

Dementia patients may benefit from a promising new treatment called Cerebrolysin, according to the results of a systematic review published in The Cochrane Library. The authors brought together the most up-to-date evidence on Cerebrolysin as a treatment for vascular dementia.

31 Jan 2013