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Pfizer, Repligen sign licensing deal to advance spinal muscular atrophy program

Repligen Corporation announced today that it has entered into an exclusive worldwide licensing agreement with Pfizer Inc. to advance Repligen's spinal muscular atrophy (SMA) program, originally in-licensed from Families of SMA (FSMA).

3 Jan 2013

Researchers analyze impact of 3 unexpected sex determination factors

So, is it a girl or a boy? This is the first question parents ask at the birth of an infant. Though the answer is obvious, the mechanism of sex determination is much less so. Researchers at the University of Geneva (UNIGE) attempt to shed light on this complex process by identifying the crucial role played by insulin and IGF1 and IGF2 growth factors, a family of hormones known for its role in metabolism and growth.

3 Jan 2013

FDA approves Abbott’s XIENCE Xpedition Everolimus Eluting Coronary Stent System

Abbott today announced that the XIENCE Xpedition Everolimus Eluting Coronary Stent System received U.S. Food and Drug Administration (FDA) approval and is launching immediately in the United States, providing physicians with a next-generation technology with the largest size matrix in the U.S. market.

3 Jan 2013

Alcohol-impregnated disinfection caps would prevent 21 CLABSIs and four deaths each year

Central line-associated bloodstream infections (CLABSI) dropped by 52 percent when an alcohol-impregnated disinfection cap was used instead of standard scrubbing protocol, according to a new study published in the January issue of the American Journal of Infection Control, the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC).

3 Jan 2013

Celtaxsys commences CTX-4430 Phase 1 study to treat pulmonary inflammation

Celtaxsys, Inc., a private biopharmaceutical company developing a new class of drugs to treat chronic inflammatory disorders, today announced the initiation of a first-in-human Phase 1 clinical study of CTX-4430, which blocks the pro-inflammatory enzyme Leukotriene A4 Hydrolase (LTA4H).

3 Jan 2013

FDA clears Soft Tissue Regeneration’s STR GRAFT

Soft Tissue Regeneration, an early stage orthopedic device company that has developed a breakthrough tissue engineering platform used to regenerate ligaments and tendons, announced today that it has received FDA clearance to market its STR GRAFT, a biodegradable scaffold used for soft tissue augmentation and rotator cuff repair.

3 Jan 2013

Longer looks: DIY abortions and the law; Helping other parents reach out to mentally ill children; Human growth hormone and Big Pharma

McCormack knew that an abortion would cost $400 to $2,000, depending on how far along she was. ... She couldn't come up with that kind of money. So she called her older sister, who owned a computer, and asked her to order abortion pills for her on the Internet.

3 Jan 2013

Vascular reconstruction raises pancreatic resection complication rates

Performing vascular reconstruction during surgical resection for pancreatic cancer is associated with a greater likelihood of postoperative adverse outcomes than resection alone, say US researchers.

3 Jan 2013

Treatment relieves oxidative stress in periodontitis

Nonsurgical periodontal therapy significantly reduces oxidative stress in individuals with chronic periodontitis, research shows.

3 Jan 2013

Craniofacial morphology linked to childhood sleep-disordered breathing

Children with abnormal craniofacial morphology are at increased risk for having sleep-disordered breathing, say researchers.

3 Jan 2013

Acute stress in childhood increases serious mental illness risk

The sudden death of a close family member in childhood is associated with an increased risk for serious mental illnesses in later life, study results show.

3 Jan 2013

Gait abnormalities found in diabetic neuropathy

Ankle muscle strength and joint mobility are the key factors influencing gait abnormalities in people with diabetic peripheral neuropathy, Brazilian research suggests.

3 Jan 2013

Neonatal chemokines altered in autistic spectrum patients

A study by scientists has found limited evidence to support a role for proinflammatory chemokines in the pathophysiology of Autism Spectrum Disorders.

3 Jan 2013

MRI could serve as lumbar puncture proxy

Structural brain patterns on magnetic resonance imaging predict cerebrospinal fluid biomarker levels in patients with suspected Alzheimer’s disease or frontotemporal lobar degeneration, preliminary research suggests.

3 Jan 2013

Low-carbohydrate diet effective in juvenile myoclonic epilepsy

Dietary modification can be an effective adjunct to drugs in people with juvenile myoclonic epilepsy, according to a study reported in Epilepsy and Behavior.

3 Jan 2013

Novel implant for craniofacial reconstruction has mixed results

A single-stage, surface-mounted implant designed using the principles of the intraosseous transcutaneous amputation prosthesis is an effective bone anchor for an external prosthesis but may not produce good cosmetic outcomes in complex craniofacial reconstruction, researchers say.

3 Jan 2013