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Factors increasing risk for pertussis in children evaluated

Research shows that children with pertussis infection are significantly less likely to have had all five diphtheria, tetanus, and acellular pertussis vaccine doses than uninfected children.

28 Nov 2012

Biomarker for ALS progression shows promise

Levels of a neurofilament subunit in cerebral spinal fluid, serum, or plasma may predict disease progression in individuals with amyotrophic lateral sclerosis, report researchers.

28 Nov 2012

Dutasteride delays PSA progression

The 5α-reductase inhibitor, dutasteride, delays the clinical progression of prostate cancer in patients with prostate-specific antigen levels that have failed to reduce adequately following radical therapy for localized disease, report researchers.

28 Nov 2012

School status may affect later smoking susceptibility

A low peer status in adolescence could significantly increase the risk for heavy and regular smoking in adulthood, researchers suggest.

28 Nov 2012

Brain effects of high-altitude sickness retained long term

Mountaineers who experience high-altitude cerebral edema often retain traces of the bleed in their brains for many years afterward, show study findings.

28 Nov 2012

Polydipsia linked to brain alterations in schizophrenia

Psychogenic polydipsia is associated with significantly reduced left insula volume in patients with schizophrenia, researchers report.

28 Nov 2012

Bleeding risk modifies perioperative beta-blocker benefits

Perioperative use of beta blockers seems to be beneficial unless patients experience heavy bleeding, in which case it may be detrimental, say researchers.

28 Nov 2012

Digoxin for atrial fibrillation questioned

Experts are calling into question the widespread use of digoxin for atrial fibrillation, in the wake of findings linking the drug to increased mortality.

28 Nov 2012

Two-route drug combination best for horse joint pain

A combination of systemic nonsteroidal anti-inflammatory drugs plus intrasynovial glucocorticosteroids is superior to either medication alone in improving outcomes for lame horses with perisynovial pain of the metacarpophalangeal joint, report Dutch researchers.

28 Nov 2012

Watch out for Sjögren's syndrome in dry eye

Clinicians with patients who have clinically significant dry eye should be on the alert for underlying Sjögren's syndrome, report researchers in the British Journal of Ophthalmology.

28 Nov 2012

Hospice patients accepting of student examinations

The majority of hospice inpatients are happy to be examined by medical students, indicate the results of a UK study.

28 Nov 2012

Nontraditional velopharyngoplasty predictor unveiled

The necessity of subsequent velopharyngoplasty does not depend on the time of soft palate closure and type of cleft, say researchers.

28 Nov 2012

Hemorrhage risk ‘higher than reported’ for AF warfarin users

Real-world findings for atrial fibrillation patients using warfarin point to a significantly higher risk for hemorrhage than reported for clinical trials.

28 Nov 2012

Chalmers researcher develops world's first implantable robotic arm controlled by thoughts

The world's first implantable robotic arm controlled by thoughts is being developed by Chalmers researcher Max Ortiz Catalan. The first operations on patients will take place this winter.

28 Nov 2012

Solvias, Hovione partner to develop and supply pharmaceutical co-crystals

Hovione and Solvias today announced the establishment of a collaboration focused on the development and GMP supply of pharmaceutical co-crystals. This strengthens Hovione's expertise and experience in overcoming drug delivery challenges and also the supply of GMP materials from phase I to commercial scale, with Solvias' excellence in solid state chemistry.

28 Nov 2012

Combination of mixed amphetamine salts and topiramate shows promise for cocaine dependence

Medication development efforts for cocaine dependence have yet to result in an FDA approved treatment. The powerful rewarding effects of cocaine, the profound disruptive impact of cocaine dependence on one's lifestyle, and the tendency of cocaine to attract people who make poor life choices and then exacerbate impulsive behavior all make cocaine a vexing clinical condition.

28 Nov 2012

Aviacode, NextGen partner to provide integrated cloud-delivered medical coding services

NextGen Healthcare Information Systems, LLC., a wholly owned subsidiary of Quality Systems, Inc. and a leading provider of healthcare information systems and connectivity solutions, announced today it has partnered with Aviacode, the industry leader in technology-enabled medical coding services, to provide integrated cloud-delivered medical coding services to NextGen Healthcare clients.

28 Nov 2012

Trovagene develops first molecular diagnostic test to detect KRAS mutations from urine samples

Trovagene, Inc. today announced successful development of its first molecular diagnostic test capable of detecting KRAS mutations from a urine specimen. Transfer of the transrenal KRAS test to the company's CLIA lab is expected to be completed in December 2012 with commercial availability expected in January 2013.

28 Nov 2012

Warfarin treatment after aortic valve replacement reduces risk of cardiovascular death

Although current guidelines recommend 3 months of anticoagulation treatment after bioprosthetic aortic valve replacement surgery, a study that included more than 4,000 patients found that patients who had warfarin therapy continued between 3 and 6 months after surgery had a lower rate of cardiovascular death, according to a study in the November 28 issue of JAMA.

28 Nov 2012

Contralateral prophylactic mastectomy does not reduce breast cancer recurrence

About 70 percent of women who have both breasts removed following a breast cancer diagnosis do so despite a very low risk of facing cancer in the healthy breast, new research from the University of Michigan Comprehensive Cancer Center finds.

28 Nov 2012