1. Luke DP Luke DP United Kingdom says:

    I wouldn't say it's ridiculous- it's certainly outlandish to make conclusions, but the inability to reach the in vitro IC50 is not an insignificant finding and emphasizes the need for researched alternative methods of delivery.
    Because the mechanism is most likely inhibition of the Importin alpha beta 1 dimer which is involved in the entry of Sars-Cov-2, it is hard to see how bound ivermectin could be significantly beneficial
    The data on pulmonary accumulation is from the study she cited
    It seemed like she also acknowledged that a lower dose than the IC50 could still have a beneficial antiviral effect, but rightfully called for caution before pinning hopes on it as a panacea.
    I agree that the title is sensationalistic at best.

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