In life sciences research and development (R&D), to truly enhance fragmented data, it must be both accessible and relevant. LabVantage BioTech360 serves as the platform that guarantees valuable information is available for informed decisions throughout the R&D process. This tool increases the actionability of data, empowers analytics and AI in a controlled manner, and ultimately reduces the time from discovery to market.
Why is a better tool necessary?
Scientific progress hinges on the credibility of data, yet pharmaceutical and biotechnology firms today confront the substantial challenge of significantly fragmented data. Information concerning sequences, samples, analytical methods, or experimental results is often scattered across various documents, databases, and tools. Moreover, proprietary in-house data and public knowledge from open-source repositories frequently remain unlinked. This fragmentation complicates researchers' efforts to gather and integrate data to form a cohesive understanding, hindering effective decision-making.
Image Credit: LabVantage Solutions
BioTech360 is an end-to-end scientific knowledge management platform designed for life sciences applications, featuring a library of use cases that address these issues by organizing and connecting both in-house and public data. By adhering to FAIR principles—making data Findable, Accessible, Interoperable, and Reusable—the platform aids scientists in uncovering insights, reproducing results, and alleviating the burden of locating the right information. This, in turn, accelerates scientific advancement, enhances collaboration, and optimizes the use of resources. Organizational leaders can thus make quicker, data-driven decisions, aligning with market demands and maintaining competitiveness.
Achieve enhanced insights with the R&D data tool for complex systems
Reveal insights with a dynamic knowledge graph
BioTech360 employs semantic technology to construct a dynamic knowledge graph that interlinks proprietary data with public datasets. This innovative approach fills knowledge gaps and is backed by ontologies, ensuring comprehensive data connectivity and comprehension. Researchers can navigate the intricacies of scientific processes using this meaningful and contextual knowledge graph. For instance, in the realm of antibody development, this graph can seamlessly connect data across various stages—from antibody discovery and screening to optimization, safety testing, manufacturing, and purification.
By offering a unified perspective, it allows researchers to monitor the entire lifecycle of an antibody, correlating disease pathology with therapeutic development, ensuring that every piece of data is accessible. Data narrates a story through its interconnections. This holistic viewpoint improves decision-making and accelerates innovation by revealing insights that might otherwise be overlooked when data is compartmentalized.
Connect and automate your operational workflow with LIMS
The integration of BioTech360 with LabVantage LIMS provides considerable advantages for both R&D and manufacturing teams. For R&D, this integration centralizes essential data—such as sequences for expression systems and drug targets—and enriches it with information from public databases and real-time experimental results.
This streamlines knowledge transfer between the various stages of the R&D process, expediting, for instance, the optimization of therapeutic proteins. It also allows researchers to initiate lab workflows directly from the knowledge base, enhancing productivity and ensuring synchronized experiments. Moreover, this integration simplifies data compilation for regulatory submissions, thereby accelerating the time to market for new therapies.
For manufacturing teams, integration provides direct access to R&D insights, enabling more informed decisions that enhance production processes. This comprehensive approach guarantees seamless tracking and management of information from research through to production, improving overall efficiency and coordination across both teams.
Built to scale with your organization
Whether managing an increased volume of data or supporting more complex analytical processes, BioTech360 is designed to quickly incorporate new concepts and functionalities, accommodate dynamic project scopes, and integrate new data sources and tools to adapt to workflows and scale with the organization efficiently.
Make your data FAIR
BioTech360 emphasizes the importance of making data Findable, Accessible, Interoperable, and Reusable (FAIR). By structuring data using semantic technology and ontologies, the platform ensures that data is well-organized, easily integrated, and accessible. This commitment to FAIR principles fosters transparency, reproducibility, and collaborative research, laying the groundwork for artificial intelligence (AI) and meaningful analytics. By aligning FAIR principles with AI, BioTech360 cultivates a more innovative and efficient development pipeline from research to market.
BioTech360 transitions researchers from managing isolated data to overseeing a rich, interconnected knowledge base. This transformation enhances efficiency and quality in life sciences R&D operations, providing a competitive advantage in biotechnology.
Everything you need throughout the R&D lifecycle
BioTech360 supports every phase of the R&D cycle, from planning and design to review and decision-making. The R&D team operates more quickly and efficiently with streamlined sequence management, advanced search capabilities, and integration with public databases. Scientists can trace their information on multiple levels, quickly locate what they need, and gain deeper insights.
Figure 1. Ensuring a Data-Driven R&D Process: From Planning and Design to Execution, Analysis, Review, and Decision-Making. Image Credit: LabVantage Solutions
Planning and design
- Unified sequence knowledge base: Standardize registration, storage, and management of DNA, RNA, and protein sequences, including automatic calculation of physicochemical properties and visualization of sequences and 3D protein structures.
- Integration of public databases: Seamlessly connect public life science databases such as UniProt, PDB, or Chembl Drug Targets with internal data through a knowledge graph.
- Pre-configured use cases: Benefit from flexible, pre-configured use cases that include configurable business logic.
Experimentation
- LIMS/ELN integration: Initiate lab processes and automatically update the sequence knowledge base with experimental results, enriching the knowledge base with insights from experiments.
- Centralized repository for experimental and analytical data: Link samples and experimental data directly to sequences, capturing relationships and integrating diverse data sets for more effective analysis.
- Comprehensive experimental data support: Accommodates various data types, including screening/assay results and omics data, facilitating broader scientific analysis.
Analysis
- Advanced sequence analysis: Analyze and compare sequences within the repository and with integrated public databases like UniProt, RefSeq, PDB, or Patents.
- Sequence annotation: Annotate sequences with metadata and connect relevant information directly to each sequence.
- Statistical tools and advanced analytics integration: Extract insights using integrated tools like R-statistics and machine learning. Visualize and compare data effortlessly using charts, tables, bar graphs, line plots, and scatter plots.
Review and decision-making
- Detailed reporting and export capabilities: Access comprehensive reports for sequences and associated information. Export sequences and metadata in various formats.
- Collaborative data sharing: Utilize team functionalities to facilitate collaboration and data sharing among researchers.
- Generative AI-augmented semantic search and filtering: Leverage advanced filtering, concept search, and generative AI-enhanced question answering and semantic similarity to analyze both structured and textual data across projects and teams.
Applications for life sciences
BioTech360 is built on a suite of research-focused knowledge bases, each featuring specialized applications designed for efficient Life Science R&D. These interconnected knowledge bases allow scientists to navigate smoothly across different research domains. Users can easily select and utilize applications that cater to their specific research requirements.
For instance, BioTech360 encompasses specialized applications for nanobodies, plasmids, and biological sequences from genomes, each tailored to streamline distinct aspects of Life Science R&D.
For research in oncology, immunology, and infectious diseases
Research involving antibodies or nanobodies holds significant potential in the treatment and diagnosis of cancer and infectious diseases. However, the vast amounts of data generated—particularly high-throughput screening and sequencing data—often lack an effective retrieval system. BioTech360 includes a dedicated application designed to manage and analyze large quantities of nanobody sequence data swiftly; by integrating with over 70 public databases, researchers can access and cross-reference relevant sequence details and visualize 3D structures.
For research in molecular biology, microbiology, and synthetic biology
Pharma R&D frequently utilizes plasmids for developing gene therapies, studying the effects of therapeutic genes, or testing the impact of drugs on gene expression and protein function. BioTech360 features an application that allows users to import, manage, and annotate plasmid sequences while ensuring data integrity through automatic checks and enforced metadata standards. It supports version control, integrates with external databases and bioinformatics tools, and includes detailed audit trails, customizable search options, and export functionalities, as well as synchronization with LIMS systems.
Figure 2. BioTech360 enables users to import, manage, and annotate plasmid sequences while ensuring data integrity. Data can also be synchronized with your LIMS system. Image Credit: LabVantage Solutions
For genomics study
BioTech360 offers extensive access to genomic data, encompassing eukaryotic, prokaryotic, and viral genomes. It enables users to search and manage genes, proteins, and genomes while integrating with external databases for enriched information. Detailed reports, visualizations, and integration with bioinformatics tools enhance the overall research experience.
All applications feature sophisticated and configurable search and filtering options, along with tagging, bookmarking, audit trails, and collaborative sharing capabilities, to streamline data management and facilitate effective research workflows and collaboration.
These three applications illustrate BioTech360’s capabilities, and additional applications will be developed and tailored to meet the evolving needs of users, further enhancing research efficiency and collaboration.
Figure 3. BioTech360 offers extensive access to both in-house and public genomic data sources, enabling users to efficiently manage genes, proteins, and genomes while facilitating collaborative work. Image Credit: LabVantage Solutions
About LabVantage Solutions
LabVantage Solutions, Inc. is the leading global laboratory informatics provider. Our industry-leading LIMS and ELN solution and world-class services are the result of 35+ years of experience in laboratory informatics. LabVantage offers a comprehensive portfolio of products and services that enable companies to innovate faster in the R&D cycle, improve manufactured product quality, achieve accurate recordkeeping and comply with regulatory requirements.
LabVantage is a highly configurable, web-based LIMS/ELN that powers hundreds of laboratories globally, large and small. Built on a platform that is widely recognized as the best in the industry, LabVantage can support hundreds of concurrent users as well as interface with instruments and other enterprise systems. It is the best choice for industries ranging from pharmaceuticals and consumer goods to molecular diagnostics and bio banking. LabVantage domain experts advise customers on best practices and maximize their ROIs by optimizing LIMS implementation with a rapid and successful deployment.
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