Natural cyclodextrins (CDs) and their synthetically modified derivatives, hydroxypropyl-β-cyclodextrin (HP-β-CD) and sulfobutyl-β-cyclodextrin (SB-β-CD), are widely used in pharmaceuticals as excipients and, in some cases, as active ingredients. These chemical modifications play a crucial role in enhancing complexation efficiency and ensuring product safety, which makes precise analytical control essential.
Image Credit: abdullah mubarak achmad/Shutterstock.com
Nuclear Magnetic Resonance (NMR) is a key tool for this purpose in compendial testing. This whitepaper illustrates how USP-NF and Ph. Eur. NMR assay methods for HP-β-CD and SB-β-CD can be seamlessly adapted for use with the Bruker Fourier 80 benchtop NMR spectrometer.
Compact and cryogen-free, the Fourier 80 is ideally suited for Quality Control laboratories and provides a practical, flexible alternative for determining the grafting ratio of CDs, simplifying the workflow compared to the original, more demanding monograph procedures.
About Bruker BioSpin - NMR, EPR and Imaging - Pharma
Welcome to Bruker BioSpin and the world's most comprehensive range of NMR and EPR spectroscopy and preclinical imaging research tools. The Bruker BioSpin Group of companies develop, manufacture and supply technology to research establishments, commercial enterprises and multi-national corporations across countless industries and fields of expertise.
Bruker BioSpin is continuing to revolutionize the design, manufacture and distribution of life science, preclinical, process control and analytical research tools based on magnetic resonance and multimodal imaging technologies. Bruker BioSpin is the worldwide technology and market leader in magnetic resonance technologies (NMR, EPR) and offers the largest portfolio of imaging modalities for preclinical and industrial research under a single brand.
Sponsored Content Policy: News-Medical.net publishes articles and related content that may be derived from sources where we have existing commercial relationships, provided such content adds value to the core editorial ethos of News-Medical.Net which is to educate and inform site visitors interested in medical research, science, medical devices and treatments.