Natural cyclodextrins (CDs) and their synthetically modified forms, hydroxypropyl-β-cyclodextrin (HP-β-CD) and sulfobutyl-β-cyclodextrin (SB-β-CD), are critical components in pharmaceutical formulations, serving as excipients and, in some cases, as active ingredients. The degree and nature of chemical modification directly influence their complexation efficiency and safety profile, making precise analytical control essential.
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Compendial methods rely on Nuclear Magnetic Resonance (NMR) to meet this need. This whitepaper demonstrates how the USP-NF and Ph. Eur. NMR assay procedures for HP-β-CD and SB-β-CD can be effectively implemented using the Bruker Fourier 80 benchtop NMR spectrometer.
Designed for Quality Control laboratories, this compact, cryogen-free system offers a flexible, practical alternative for determining cyclodextrin grafting ratios - streamlining the workflow and simplifying execution of the monograph procedures.
Download the full whitepaper here.
About Bruker BioSpin Division
The Bruker BioSpin Division designs, manufactures, and distributes advanced scientific instruments based on magnetic resonance, preclinical imaging technologies, and biosensor technologies. These include our industry-leading NMR and EPR spectrometers, imaging systems utilizing MRI, PET, SPECT, CT, Optical and MPI modalities, as well as molecular interaction technologies like SPR, switchSENSE® and single-cell Interaction Cytometry (scIC). The Division also offers integrated software solutions and automation tools to support digital transformation across research and quality control environments.
Our customers in academic, government, industrial, and pharmaceutical sectors rely on these technologies to gain detailed insights into molecular structure, dynamics, and interactions. Our solutions play a key role in structural biology, drug discovery, disease research, metabolomics, and advanced materials analysis. Recent investments in lab automation, optical imaging, and contract research services further strengthen our ability to support evolving customer needs and enable scientific innovation.
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