In pharmaceutical development and manufacturing, monitoring reactions in real time - and adjusting instantly to changes in process conditions - is no longer optional. Process Analytical Technology (PAT) has become both a scientific necessity and a regulatory expectation.
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At the heart of this approach is the integration of real-time analytical techniques with process control systems, a capability that underpins both PAT and Quality by Design (QbD) frameworks.
In this article, Bruker’s Fourier 80 benchtop Nuclear Magnetic Resonance (NMR) spectrometer was coupled with a PAT software platform to deliver continuous, on-line, and in-line reaction monitoring, paired with automated process control.
The results show how benchtop NMR can serve as a practical, information-rich PAT solution, offering the insights needed to strengthen process understanding, improve control, and increase automation in both pharmaceutical development and production.
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Acknowledgments
This article is based on materials originally authored by Isabel A. Thomlinsom (University of Bath), Philip B. Yang (University of Bath) and Alejandro Bara-Estaún (Bruker).
About Bruker BioSpin Division
The Bruker BioSpin Division designs, manufactures, and distributes advanced scientific instruments based on magnetic resonance, preclinical imaging technologies, and biosensor technologies. These include our industry-leading NMR and EPR spectrometers, imaging systems utilizing MRI, PET, SPECT, CT, Optical and MPI modalities, as well as molecular interaction technologies like SPR, switchSENSE® and single-cell Interaction Cytometry (scIC). The Division also offers integrated software solutions and automation tools to support digital transformation across research and quality control environments.
Our customers in academic, government, industrial, and pharmaceutical sectors rely on these technologies to gain detailed insights into molecular structure, dynamics, and interactions. Our solutions play a key role in structural biology, drug discovery, disease research, metabolomics, and advanced materials analysis. Recent investments in lab automation, optical imaging, and contract research services further strengthen our ability to support evolving customer needs and enable scientific innovation.
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