Analytical Quality by Design (AQbD) principles call for a deeper, more systematic understanding of all factors that influence the performance of analytical procedures in quality control. By embedding science and risk management into the core of method development, AQbD promotes the creation of “living” procedures, where every variable is well-characterized, controlled, and continuously monitored.
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While the holistic approach introduced by AQbD can be complex, it offers clear benefits: improved method robustness, greater quality assurance, and increased flexibility. Notably, it also introduces the concept of platform procedures, which can be adapted across multiple applications with minimal revalidation.
In this context, Nuclear Magnetic Resonance (NMR) emerges as a powerful tool to support AQbD. Grounded in absolute physical principles, NMR simplifies the management of analytical procedures and fully leverages the platform concept.
This whitepaper explores how to design and implement such a platform for quantitative applications using Bruker’s compact, cryogen-free benchtop NMR spectrometer, the Fourier 80.
It begins with key considerations for risk assessment in quantitative NMR (qNMR) procedures and then presents practical control and mitigation strategies. Real-world examples illustrate how to define a Method Operable Design Region (MODR) using the Fourier 80, offering a practical roadmap for labs seeking to adopt flexible, streamlined qNMR methods.
Download the full whitepaper here.
About Bruker BioSpin Division
The Bruker BioSpin Division designs, manufactures, and distributes advanced scientific instruments based on magnetic resonance, preclinical imaging technologies, and biosensor technologies. These include our industry-leading NMR and EPR spectrometers, imaging systems utilizing MRI, PET, SPECT, CT, Optical and MPI modalities, as well as molecular interaction technologies like SPR, switchSENSE® and single-cell Interaction Cytometry (scIC). The Division also offers integrated software solutions and automation tools to support digital transformation across research and quality control environments.
Our customers in academic, government, industrial, and pharmaceutical sectors rely on these technologies to gain detailed insights into molecular structure, dynamics, and interactions. Our solutions play a key role in structural biology, drug discovery, disease research, metabolomics, and advanced materials analysis. Recent investments in lab automation, optical imaging, and contract research services further strengthen our ability to support evolving customer needs and enable scientific innovation.
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