Analytical Quality by Design (AQbD) principles call for a deeper, more systematic understanding of all factors that influence the performance of analytical procedures in quality control. By embedding science and risk management into the core of method development, AQbD promotes the creation of “living” procedures, where every variable is well-characterized, controlled, and continuously monitored.
While the holistic approach introduced by AQbD can be complex, it offers clear benefits: improved method robustness, greater quality assurance, and increased flexibility. Notably, it also introduces the concept of platform procedures, which can be adapted across multiple applications with minimal revalidation.
In this context, Nuclear Magnetic Resonance (NMR) emerges as a powerful tool to support AQbD. Grounded in absolute physical principles, NMR simplifies the management of analytical procedures and fully leverages the platform concept.
This whitepaper explores how to design and implement such a platform for quantitative applications using Bruker’s compact, cryogen-free benchtop NMR spectrometer, the Fourier 80.
It begins with key considerations for risk assessment in quantitative NMR (qNMR) procedures and then presents practical control and mitigation strategies. Real-world examples illustrate how to define a Method Operable Design Region (MODR) using the Fourier 80, offering a practical roadmap for labs seeking to adopt flexible, streamlined qNMR methods.
Download the full whitepaper here.
About Bruker BioSpin - NMR, EPR and Imaging - Pharma
Welcome to Bruker BioSpin and the world's most comprehensive range of NMR and EPR spectroscopy and preclinical imaging research tools. The Bruker BioSpin Group of companies develop, manufacture and supply technology to research establishments, commercial enterprises and multi-national corporations across countless industries and fields of expertise.
Bruker BioSpin is continuing to revolutionize the design, manufacture and distribution of life science, preclinical, process control and analytical research tools based on magnetic resonance and multimodal imaging technologies. Bruker BioSpin is the worldwide technology and market leader in magnetic resonance technologies (NMR, EPR) and offers the largest portfolio of imaging modalities for preclinical and industrial research under a single brand.
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