Aging News and Research

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Women use creatine differently from men, survey reveals

A cross-sectional survey of 2,094 current or recent creatine users found that women were more concentrated in shorter-duration use groups than men and reported different supplementation goals, information sources, and knowledge patterns. Women were less likely to cite athletic performance and more likely to cite healthy aging as a goal, while researchers cautioned that the survey design cannot explain why these differences exist.

10 Sep 2026

Groundbreaking movement span framework redefines how we measure aging

Longstanding aging metrics have focused on how long people live and how long they live free of chronic disease, but both overlook a core component of daily well-being: the ability to move through the world with ease and confidence.

10 Sep 2026

Aging brain actively shapes biology and progression of tumors

Brain tumors develop within an organ that changes substantially with age. A new review in Ageing and Cancer Research & Treatment examines evidence that the aging brain microenvironment may influence brain tumor progression, treatment resistance, and cognitive outcomes.

10 Sep 2026

Review highlights solute carriers as targets for central nervous system disorders

Solute carriers (SLCs) are specialized transport proteins that control the movement of nutrients, ions and neurotransmitters across cell membranes and are essential for brain metabolism and neuronal communication.

10 Sep 2026

Generative AI-driven drug Rentosertib enters Phase III trial for idiopathic pulmonary fibrosis

Insilico Medicine, a clinical-stage biotechnology company powered by generative AI, today announced that it has dosed the first patient with Rentosertib (known as ISM001-055 / INS018_055) in GENESIS-IPF-3, a Phase III clinical trial (NCT07687459, CTR20262475) at Peking Union Medical College Hospital, while Shanghai Pulmonary Hospital has also enrolled its first patient on the same day.

10 Sep 2026

Rentosertib shifts multiple proteomic aging clocks toward younger age profiles in IPF trial

Researchers applied six proteomic aging clocks to serum samples from a phase 2a trial of rentosertib in people with idiopathic pulmonary fibrosis and found treatment-associated shifts toward younger predicted biological-age profiles, particularly with the 30 mg twice-daily regimen. Additional proteomic analyses linked treatment to changes in senescence, metabolism, growth-factor signaling, and fibrosis-related pathways, although the study could not determine whether these effects reflected genuine geroprotection rather than disease modification.

10 Sep 2026

Gut microbiome may reveal inflammation and future disease risk better than age

Gut microbiota composition explained more variation than chronological age in nearly all inflammatory cytokines and most physiological measures examined, with specific microbial profiles linked to markedly different patterns of inflammation across adulthood. People with the Bacteroides 2 enterotype showed an inflammaging-like profile decades earlier than other groups and had a higher risk of subsequent disease, while a high-diversity microbiota profile was associated with lower inflammation and reduced disease incidence.

9 Sep 2026

Pink noise boosts brain waste clearance during sleep

During the day, waste products such as lactic acid and worn-out proteins build up in the brain. When we sleep at night, waves of cerebrospinal fluid (CSF) help to wash away this waste, keeping the brain healthy.

9 Sep 2026

Technological roadmap proposed for lifetime brain-wide neural recordings

Understanding the brain requires tools that can follow neural activity across many scales: from millisecond electrical spikes in individual neurons to brain-wide circuit dynamics that change over months, years, and even a lifetime.

9 Sep 2026

Caloric restriction reduces genetic mutations across the mouse genome

Mutations are changes in the molecular "letters" that make up DNA, the genetic blueprint for cells. Mutations build up with age in every cell when DNA is damaged or when cells make mistakes in fixing or copying it.

9 Sep 2026

New blood screening algorithm reduces unnecessary Alzheimer's PET scans

A new blood-based screening algorithm dramatically reduced the number of unnecessary PET scans needed to recruit patients at risk of Alzheimer's disease for a clinical trial, according to research from scientists at the Keck School of Medicine of USC published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

9 Sep 2026

Cognitive behavioral therapy for insomnia may slow biological aging in older adults

A new UCLA Health study found that treatment of insomnia using cognitive behavioral therapy slowed the pace of biological aging in older adults.

8 Sep 2026

Hormone therapy during menopause transition associated with lower heart disease risk

A study led by Virginia Commonwealth University and the University of Pittsburgh provides pivotal insights into one of the most debated questions in women's health: how does hormone therapy for menopause symptoms affect cardiovascular disease risk when used in peri- or early postmenopause?

8 Sep 2026

Could one amino acid help explain why men tend to live shorter lives?

A UK Biobank cohort and Mendelian randomization study involving 272,475 participants linked higher circulating tyrosine with greater all-cause mortality and genetically predicted higher tyrosine with shorter lifespan. After accounting for phenylalanine, the relationship with shorter lifespan was clearest in men, while findings in women were less consistent, suggesting a potential sex-specific role for tyrosine in longevity.

7 Sep 2026

AI-designed drug candidate reverses biological age in clinical study

Insilico Medicine ("Insilico"), a clinical-stage company focused on generative AI-driven drug discovery and development, today announced the publication of a new study conducted in collaboration with an international team of scientists from Harvard Medical School, Stanford University, The Broad Institute, RWTH Aachen University, Peking University and Westlake University.

7 Sep 2026

Scientists traced a hidden immune route that may worsen tau-linked brain damage

In a mouse model of tauopathy, conventional type 1 dendritic cells (cDC1s) cross-presented brain-derived antigens in deep cervical lymph nodes, priming CD8+ T cells that accumulated in the brain and promoted neurodegeneration. Disrupting cDC1s or their cross-presentation activity reduced CD8+ T-cell infiltration and protected against neuronal loss, while human primary tauopathy samples also showed increased brain CD8+ T cells, although cDC1 involvement in humans remains unconfirmed.

6 Sep 2026

Yoga with a cognitive twist showed some intriguing benefits in older adults

A 24-week pilot randomized trial found that both traditional Hatha yoga and a faster, cognitively demanding YogaCue program were associated with improvements in cognitive and physical performance in independently living older adults. YogaCue showed promising additional gains in verbal and episodic memory, aerobic fitness, and lower-body power, although the small study could not establish clear superiority over Hatha yoga across all outcomes.

6 Sep 2026