BRCA1 Gene News and Research

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BRCA1 is a gene on chromosome 17 that normally helps to suppress cell growth. A person who inherits certain mutations (changes) in a BRCA1 gene has a higher risk of getting breast, ovarian, prostate, and other types of cancer.

Breast and ovarian cancers linked by heredity - women need to know their risks

During September, Gynecologic Cancer Awareness Month, the Gynecologic Cancer Foundation (GCF) urges women to learn more about familial breast-ovarian cancer syndrome.

12 Sep 2006

Validation of a tool for identifying women at high risk for hereditary breast cancer

A new screening tool for the general practitioner effectively identifies patients at risk for hereditary breast cancer, according to a new study.

11 Sep 2006

Findings shed new light on BRCA1 and BRCA2 breast-cancer gene mutations in older and African-American women

Clearest picture yet of the prevalence and predictors of mutations in the breast-cancer susceptibility genes BRCA1 and BRCA2 among women in the general population.

15 Aug 2006

Gene amplification links growth controlling pathway from Drosophila to human cancers

Researchers at Harvard Medical School (HMS) and Massachusetts General Hospital (MGH) have discovered a new cancer-promoting role for a gene potentially involved in breast, liver, and other kinds of cancers.

8 Aug 2006

Variation in the CHEK2 gene may triple a woman's risk of developing breast cancer

Study shows that women in the general population who carry a specific CHEK2 mutation are three times as likely as women without the mutation to develop breast cancer.

2 Aug 2006

Basal tumours may originate from breast stem cells that have undergone genetic mishaps

Findings support previous speculation that breast stem cells, or very early descendents, are the cells from which basal tumours arise.

24 Jul 2006

New role discovered for breast cancer susceptibility gene BRCA1

A recently discovered facet of the breast cancer susceptibility gene BRCA1 reveals a mechanism linking mutation of BRCA1 to formation of large blood vessels needed to support cancer progression.

18 Jul 2006

Women with mutations in BRCA1 or BRCA2 genes can reduce cancer risk by having ovaries removed

Women with mutations in the BRCA1 or BRCA2 genes can significantly reduce their risk of certain types of cancer by having their ovaries removed, according to a study in the July 12 issue of Journal of the American Medical Association.

12 Jul 2006

Scientists unravel breast cancer risk gene mystery

The risk of developing breast cancer is doubled in women who inherit a damaged version of a gene called ATM, according to a study published by Cancer Research UK funded scientists and collaborators in Nature Genetics.

10 Jul 2006

X-rays increase breast cancer risk

According to new research X-rays may significantly increase the risk of breast cancer in women who are genetically susceptible to the disease.

27 Jun 2006

Two year wait for breast cancer test results drives women to consider radical surgery

Women in the UK being put under added stress because they are experiencing delays of two years or more for test results to see if they carry a gene associated with an increased likelihood of breast cancer.

20 Jun 2006

New genetic clue discovered about breast cancer

New research has discovered that women in Iceland with a particular gene that raises the risk of breast cancer were virtually certain to develop the disease if they also had a mutation in another gene.

20 Jun 2006

Prophylactic surgery reduces the incidence of ovarian and related cancers

A new multicenter study is the first to suggest that the prophylactic removal of the ovaries and fallopian tubes may provide a different benefit for women who carry a genetic mutation in the BRCA2 gene than for those who have a BRCA1 genetic mutation.

7 Jun 2006

Hormonal treatments reduce risk of cancer returning

Women diagnosed with breast cancer who carry a certain genetic mutation can have breast-sparing surgery but should consider hormonal treatments to reduce their risk of cancer returning.

6 Jun 2006

MRI cost-effective for some women at high-risk of breast cancer

A computer model simulation suggests that adding breast MRI screening may be cost-effective for women of certain ages who carry BRCA1 and BRCA2 gene mutations.

23 May 2006

Extension of embryo screening will help reduce serious illness

A fertility watchdog in Britain, the Human Fertilisation and Embryology Authority (HFEA), has given approval for the extension of embryo screening to cover a wider range of mutated genes, in the main those which raise the risk of cancer in later life.

11 May 2006