Fibrosis News and Research

RSS

Fibrosis is the growth of fibrous tissue.

How gut microbes may shape heart attack damage and recovery

This review argues that gut microbes and the metabolites they produce, especially SCFAs and TMAO, may shape how the heart responds to myocardial infarction through epigenetic pathways such as DNA methylation, histone modification, and non-coding RNAs. It also outlines potential intervention routes, including diet, probiotics, postbiotics, and metabolite-targeted therapies, while noting that much of the evidence remains translational and not yet clinically definitive.

6 Apr 2026

Toxic RNA drives progressive heart damage in myotonic dystrophy

Myotonic dystrophy type 1 (DM1) is the most common cause of adult-onset muscular dystrophy, a genetic disorder that leads to muscle weakness and wasting, but also affects the brain, the gastrointestinal tract and the heart.

3 Apr 2026

Occasional heavy drinking poses major risk to liver health

People may assume that if they drink lightly during the week or month, heavy drinking on the occasional Friday or Saturday may not cause their liver harm.

2 Apr 2026

Polygenic embryo testing raises ethical concerns beyond disease prevention

For more than four decades, in vitro fertilization (IVF) has helped families have children. Scientists estimate that more than 10 million people worldwide have been born through IVF and related assisted reproductive technologies, according to the International Committee for Monitoring Assisted Reproductive Technologies.

31 Mar 2026

Lipid nanoparticles help CAR T cells melt pancreatic cancer barriers

Often diagnosed when surgery is no longer an option, pancreatic cancer is one of the most difficult cancers to treat and has one of the lowest rates of survival among major malignancies.

31 Mar 2026

Antibiotic resistance genes found in both diseased and healthy lungs

The researchers examined patients with COPD, asthma, pulmonary fibrosis (IPF), and sarcoidosis, and compared them with healthy individuals.

31 Mar 2026

Restoring tissue stiffness may reduce inflammation in gum disease

Periodontitis is a serious chronic inflammatory form of gum disease that affects millions worldwide. It can lead to tooth loss and the destruction of supporting bone.

31 Mar 2026

Study reveals CAR T approach for hard-to-treat solid tumors

Chimeric antigen receptor T-cell therapy - CAR T for short - has been a major advance in treating blood cancers like leukemia and lymphoma.

30 Mar 2026

Researchers identifiy a promising strategy to reverse pulmonary fibrosis

Researchers at National Jewish Health and collaborating institutions have uncovered a critical mechanism driving persistent pulmonary fibrosis and identified a promising strategy to reverse it.

30 Mar 2026

Ultrasound advances offer noninvasive assessment of portal hypertension severity

Portal hypertension (PH), a serious complication of liver cirrhosis, is defined as a pressure gradient > 5 mmHg between the portal vein and the inferior vena cava.

27 Mar 2026

Machine learning model predicts liver cancer risk with high accuracy

A machine learning model that analyzes patient demographics, electronic health record data, and routine blood test results predicted a patient's risk of hepatocellular carcinoma (HCC), the most common type of liver cancer, with high accuracy.

26 Mar 2026

New algorithm enables precise subtyping of metabolic liver disease

Metabolic-associated steatotic liver disease (MASLD) is a clinically heterogeneous condition with highly variable outcomes affecting more than 30% individuals globally.

26 Mar 2026

Experts propose trial to evaluate obesity medications for cancer prevention

In new research to be presented at this year's European Congress on Obesity (ECO2026) in Istanbul, Turkey (12-15 May), a global panel of 21 obesity and cancer experts suggest that to test the potential efficacy of the new generation of obesity drugs such as semaglutide and tirzepatide in preventing obesity-related cancer (ORC), a trial of the drugs for some 5,000 participants at high risk of cancer due to their having a cancer pre-cursor condition will provide the required answers.

25 Mar 2026

New nanoparticle system boosts scalable production of therapeutic exosomes

Researchers from Xi'an Jiaotong-Liverpool University (XJTLU) in China have developed a streamlined process that makes it easier to produce tiny therapeutic particles released by cells, called exosomes, which are being explored as a new type of medical treatment.

24 Mar 2026

Insilico and ASKA partner to advance AI-driven gynecological drug discovery

Insilico Medicine (3696.HK), a clinical-stage drug discovery and development company driven by generative artificial intelligence (AI), today announced a strategic research collaboration with ASKA Pharmaceutical Co., Ltd. ("ASKA"), a specialized pharmaceutical company with a strong focus on internal medicine, obstetrics, and gynecology.

24 Mar 2026

Redesigned lipid nanoparticles improve mRNA delivery to lymph nodes

Penn Engineers have redesigned a key component of lipid nanoparticles (LNPs), the delivery vehicles behind mRNA vaccines, to steer the particles toward lymph nodes while reducing off-target delivery to the liver.

24 Mar 2026

Palmatine improved fatty liver markers in a preclinical type 2 diabetes study

Researchers used a bioinformatics-plus-rat-model approach to investigate how palmatine may help treat T2DM-associated MASLD, identifying five core targets: ADRB2, BCL3, EGR1, FOS, and MAP3K8. In rats, palmatine improved liver injury, inflammation, oxidative stress, glycolipid metabolism, steatosis, and fibrosis, while reducing apoptosis-related signaling, providing a preclinical foundation for further therapeutic study.

23 Mar 2026

AI-driven atlas reveals how mouth fibroblasts regulate structural immunity

Researchers at VCU Massey Comprehensive Cancer Center are leading an international study that advances the understanding of the immunoregulatory nature of human tissues, offering breakthrough insights into how fibroblasts serve as the core regulators of structural immunity in the mouth.

23 Mar 2026

New mechanism drives adverse tumor remodeling during breast cancer progression

A research group led by Professor Cecilia Sahlgren at Åbo Akademi University (Finland) and the InFLAMES Research Flagship has identified a new mechanism directing the adverse remodeling of tumor tissue during breast cancer progression.

18 Mar 2026