Neurodegenerative Disease News and Research

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New insights reveal how sugar metabolism protects neurons from degeneration

Unlike most cells in the human body, neurons-the functional cells of our nervous system-cannot typically replace themselves with healthy copies after being damaged.

4 Aug 2025

Selective impairment of translation contributes to brain aging in killifish

Aging selectively impairs the production of crucial DNA- and RNA-binding proteins, which contributes to hallmarks of aging in the brains of killifish, according to a new study.

31 Jul 2025

Using tongue coating to spot early signs of Parkinson’s disease

Tongue coating analysis reveals potential biomarkers for early Parkinson's disease detection, offering a non-invasive and cost-effective diagnostic approach.

31 Jul 2025

Gut mycobiota could help predict disability in multiple sclerosis

Gut fungal communities may impact multiple sclerosis severity, offering new insights into MS pathogenesis and potential microbiome-based treatment strategies.

29 Jul 2025

New research identifies critical gene for ALS treatment

Amyotrophic lateral sclerosis (ALS) - which you may know as the disease that affected Stephen Hawking - is a fatal neurodegenerative disease that causes progressive muscle weakness. A research team at Tohoku University and Keio University has uncovered a unifying mechanism in ALS revolving around the expression of UNC13A (a gene crucial for neuronal communication) that represents a common target for developing effective treatment strategies that could improve the lives of patients with ALS.

26 Jul 2025

Automated cage monitoring system reveals behavioral changes in schizophrenia mouse model

Schizophrenia is a serious mental health condition that affects thoughts, moods, perceptions, and behaviors.

24 Jul 2025

Mount Sinai researcher uncovers how the brain and body interact in aging and depression

In a comprehensive Genomic Press interview published in Brain Medicine today, Dr. Hamilton Se-Hwee Oh reveals groundbreaking insights into the complex dialogue between our brains and bodies that fundamentally shapes aging, depression, and neurodegenerative disease.

22 Jul 2025

APOE ε4 variant reveals hidden risk factors beyond Alzheimer’s

Researchers discovered that people carrying the APOE ε4 gene variant share a unique immune-related protein signature across their blood, brain, and cerebrospinal fluid—regardless of neurodegenerative disease diagnosis. This signature reveals a fundamental, disease-independent vulnerability linked to APOE ε4, reframing our understanding of genetic risk in conditions like Alzheimer's, Parkinson’s, ALS, and FTD.

21 Jul 2025

New tech could revolutionize neurodegenerative disease research and AI

When electrical activity travels across the brain, it moves like ripples on a pond. The motion of these "brain waves," first observed in the 1920s, can now be seen more clearly than ever before thanks to instruments and techniques created by a Stanford-led team.

17 Jul 2025

Brain protein associated with aging not linked to youth contact sports

In recent years, some scientists and advocates have warned that playing contact sports like football and hockey may increase the risk of brain diseases like Alzheimer's disease or chronic traumatic encephalopathy (CTE) due to a buildup of a specific protein in the brain.

11 Jul 2025

Growing popularity of contact sports raises concern over brain injuries in Africa

Contact sports are becoming increasingly popular in Africa, raising concern about the risk of chronic traumatic encephalopathy (CTE).

7 Jul 2025

Flavonoid diversity, not just quantity, drives better health outcomes

This study reveals that diverse flavonoid intake is crucial for lowering chronic disease risk and mortality, advocating for a varied diet rich in flavonoids.

7 Jul 2025

First large-scale stem cell bank created to investigate Alzheimer’s genetic risk factors

Alzheimer's disease (AD) is a common, debilitating neurodegenerative disease affecting about 10 percent of people over the age of 65 and one third of people aged 85 and above. Besides environmental factors, the genes have a strong influence on whether or not a person develops AD during their lifetime.

4 Jul 2025

Glycogen metabolism in neurons emerges as key to fighting Alzheimer's

A new study from scientists at the Buck Institute for Research on Aging has revealed a surprising player in the battle against Alzheimer's disease and other forms of dementia: brain sugar metabolism.

1 Jul 2025

Can saffron treat Alzheimer’s and depression?

Saffron shows promise as a natural treatment for depression and cognitive decline, performing as well as standard drugs in clinical trials. However, more rigorous studies are needed before saffron can be recommended in mainstream psychiatric and dementia care.

26 Jun 2025

Parse Biosciences GigaLab to support Mount Sinai researchers in generating one of the largest Alzheimer's and Parkinson's single cell datasets

Parse Biosciences today announced their commitment to support researchers from the Icahn School of Medicine at Mount Sinai in generating one of the largest single cell datasets focused on understanding alternative splicing events in the cells of Alzheimer's and Parkinson's patients.

From Parse Biosciences 26 Jun 2025

Rice University recruits leading biophysicist with CPRIT support

Rice University's Department of Chemistry will soon welcome Pernilla Wittung-Stafshede, who will enhance the university's research efforts in biophysics when she joins the faculty as a professor July 1, backed by a $6 million recruitment grant from the Cancer Prevention and Research Institute of Texas (CPRIT).

25 Jun 2025

Researchers identify key differences in Alzheimer's progression in humans and animal models

Although it is known that Alzheimer's disease can start up to 20 years before the first symptoms appear, the lack of knowledge about how it progresses prevents the development of effective treatments, as well as a clear diagnosis to confront this neurodegenerative disease, which origin is also unknown.

19 Jun 2025

Uppsala researchers create 3D-printed human nerve tissue model

With the aid of a 3D printer, researchers at Uppsala University have succeeded in creating a model that resembles human nerve tissue.

18 Jun 2025

Yellow pigment linked to protection against severe malaria

New research suggests that a pigment that causes yellowing of the skin, or jaundice, may help protect people from the most severe consequences of malaria.

13 Jun 2025