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Common cell pathway could lead to new treatments for autoimmune diseases and cancer

A discovery by University of Alabama at Birmingham researchers about a how a common cell pathway that helps regulate cell survival and production is turned on could lead to new treatments for autoimmune diseases and cancer.

8 Jul 2011

Transplants with half-matched bone marrow or cord blood are comparable to fully matched tissue

Identifying a suitable donor for leukemia and lymphoma patients who need bone marrow transplants may be far easier now that results of two clinical trials show transplant results with half-matched bone marrow or umbilical cord blood are comparable to fully matched tissue, thanks in large part to the availability of effective antirejection drugs and special post-transplant chemotherapy.

8 Jul 2011

Half-matched transplants widen donor pool for leukemia and lymphoma

7 Jul 2011

Gene therapy may help prevent progression of type 1 diabetes

Increasing a specific protein in areas of the pancreas that produce insulin blocks the immune attack that causes type 1 diabetes, researchers reported in the August issue of the Journal of Clinical Investigation, published early online.

7 Jul 2011

Genetically engineered pigs may help overcome donor organ shortage

A sizzling genetic discovery by Chinese scientists may one day allow pig tissue to be transplanted successfully into humans. Their research presented in the Journal of Leukocyte Biology (http://www.jleukbio.org) represents a major step forward toward filling the shortage of vital organs for human transplantation.

1 Jul 2011

GWAS identifies 15 gene variants responsible for diversity of white blood cell counts

A trio of large-scale genome-wide association studies, or GWAS, have identified more than 15 gene variants responsible for the diversity of white blood cell counts among whites, African-Americans, and Japanese.

1 Jul 2011

DMI completes rHEALTH sensor reduced-gravity experiments for NASA FAST program

In September 2010, the DNA Medicine Institute (DMI) successfully completed reduced-gravity experiments on its rHEALTH sensor for the NASA Facilitated Access to the Space Environment for Technology (FAST) program. NASA recently followed that experiment with a $190,000 contract to DMI to analyze data from the parabolic flights.

29 Jun 2011

Omeros identifies compounds that interact with orphan GPCRs associated with leukemia

Omeros Corporation today reported that it has identified compounds that interact with orphan G protein-coupled receptors (GPCRs) P2Y8 and OPN4. P2Y8 (also known as P2RY8) is associated with acute lymphoblastic leukemia (ALL), an aggressive cancer of the white blood cells.

27 Jun 2011

Rogue super-activated neutrophils may cause organ damage in parts unconnected to injury

A study from scientists at Queen Mary, University of London, sheds new light on why people who experience serious trauma or go through major surgery, can suffer organ damage in parts of the body which are seemingly unconnected to the injury.

27 Jun 2011

Health Canada approves Tasigna for newly diagnosed Philadelphia chromosome-positive CML

Over a decade ago, Canadian patients diagnosed with chronic myeloid leukemia (CML), celebrated when PrGleevec (imatinib mesylate) was approved in Canada.

27 Jun 2011

Promising results from MGH's BCG Phase I trial on type I diabetes

Promising results of the Phase I clinical trial of the generic drug BCG to treat advanced type I diabetes were announced today at the American Diabetes Association scientific sessions in San Diego.

27 Jun 2011

Potential new approach for treating myelofibrosis

A new study conducted by a team of researchers at Boston University School of Medicine (BUSM) sheds light on a possible new approach to treat the bone marrow disease known as myelofibrosis by inhibiting an enzyme that connects extracellular fibers.

24 Jun 2011

Scientists uncover novel mechanism linked to Spinocerebellar ataxia 7

A team of scientists, led by researchers at the University of California, San Diego School of Medicine, have uncovered a novel mechanism regulating gene expression and transcription linked to Spinocerebellar ataxia 7, an inherited neurological disorder.

22 Jun 2011

Positive results from LCP-Tacro Phase III trial in stable kidney transplant recipients

LifeCycle Pharma A/S today reported that the company's lead product candidate, LCP-Tacro, successfully demonstrated non-inferiority compared to tacrolimus in its Phase III trial, Study 3001.

21 Jun 2011

University of Virginia professor speaks about gender disparity in abdominal aortic aneurysms

At the 65th Vascular Annual Meeting of the Society for Vascular Surgery, Gilbert R. Upchurch, Jr., MD from the division of thoracic and cardiovascular surgery at University of Virginia Health System in Charlottesville, spoke about gender differences in abdominal aortic aneurysms.

18 Jun 2011

Cervical ripening that instigates preterm birth is distinct from normal term labor

Cervical ripening that instigates preterm labor is distinct from what happens at the onset of normal term labor, researchers at UT Southwestern Medical Center have found.

18 Jun 2011

Adaptimmune melanoma trial opening

Adaptimmune announced today that it has opened a Phase I/II, two cohort, open label clinical trial in metastatic melanoma at Washington University, St. Louis, Missouri.

16 Jun 2011

Scientists discover new cell type in the immune system

A team of Australian scientists has discovered a new type of cell in the immune system. The new cell type, a kind of white blood cell, belongs to a family of T-cells that play a critical role in protection against infectious disease.

16 Jun 2011

Bristol-Myers Squibb receives FDA approval for Nulojix to prevent organ rejection after kidney transplant

The U.S. Food and Drug Administration today approved Nulojix to prevent acute rejection in adult patients who have had a kidney transplant. The drug is approved for use with other immunosuppressants -- specifically basiliximab, mycophenolate mofetil, and corticosteroids.

16 Jun 2011

Placental growth factor also plays a role in chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a particular form of leukemia or cancer of the bone marrow, which can be treated with targeted imatinib. However, in some cases this medicine has no effect. Researchers at the VIB Vesalius Research Centre, K.U. Leuven, under the direction of Peter Carmeliet, have investigated the role of placental growth factor (PlGF) in mice with CML.

15 Jun 2011

Leukocyte News and Research

Common cell pathway could lead to new treatments for autoimmune diseases and cancer

Transplants with half-matched bone marrow or cord blood are comparable to fully matched tissue

Half-matched transplants widen donor pool for leukemia and lymphoma

Gene therapy may help prevent progression of type 1 diabetes

Genetically engineered pigs may help overcome donor organ shortage

GWAS identifies 15 gene variants responsible for diversity of white blood cell counts

DMI completes rHEALTH sensor reduced-gravity experiments for NASA FAST program

Omeros identifies compounds that interact with orphan GPCRs associated with leukemia

Rogue super-activated neutrophils may cause organ damage in parts unconnected to injury

Health Canada approves Tasigna for newly diagnosed Philadelphia chromosome-positive CML

Promising results from MGH's BCG Phase I trial on type I diabetes

Potential new approach for treating myelofibrosis

Scientists uncover novel mechanism linked to Spinocerebellar ataxia 7

Positive results from LCP-Tacro Phase III trial in stable kidney transplant recipients

University of Virginia professor speaks about gender disparity in abdominal aortic aneurysms

Cervical ripening that instigates preterm birth is distinct from normal term labor

Adaptimmune melanoma trial opening

Scientists discover new cell type in the immune system

Bristol-Myers Squibb receives FDA approval for Nulojix to prevent organ rejection after kidney transplant

Placental growth factor also plays a role in chronic myeloid leukemia

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