Mitochondria News and Research

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Single dose restores normal cellular signaling in mouse model of autism

In a further test of a novel theory that suggests autism is the consequence of abnormal cell communication, researchers at the University of California, San Diego School of Medicine report that an almost century-old drug approved for treating sleeping sickness also restores normal cellular signaling in a mouse model of autism, reversing symptoms of the neurological disorder in animals that were the human biological age equivalent of 30 years old.

18 Jun 2014

Researchers demonstrate potential of retinoic acid in preventing type 2 diabetes complications

At a time when obesity, type 2 diabetes, and their complications are a veritable epidemic worldwide, researchers at the University of Montreal and CHUM Research Centre (CRCHUM) recently demonstrated the potential of retinoic acid (RA), a derivative of Vitamin A, in treating obesity and type 2 diabetes and preventing their cardiovascular complications.

17 Jun 2014

New genetic 'barcode' for malaria parasites could be used to track and contain spread of disease

A new genetic 'barcode' for malaria parasites has been found which could be used to track and contain the spread of the disease, according to new research led by the London School of Hygiene & Tropical Medicine.

13 Jun 2014

Edison's EPI-743 receives FDA orphan drug designation for treatment of Leigh syndrome

Edison Pharmaceuticals today announced that the FDA has granted Orphan Drug status to vatiquinone for the treatment of Leigh syndrome.

9 Jun 2014

Research findings on mTor, circadian rhythm, animal aging and FAT10 presented at AGE meeting

The 43rd Annual Meeting of the American Aging Association held May 30-June 2, 2014, at the Westin Riverwalk Hotel in San Antonio, Texas, featured the latest scholarship and research findings in the field of aging research from more than 70 leading experts.

6 Jun 2014

New gene involved in Parkinson's disease, find researchers

A team of UCLA researchers has identified a new gene involved in Parkinson's disease, a finding that may one day provide a target for a new drug to prevent and potentially even cure the debilitating neurological disorder.

5 Jun 2014

Researchers reveal potential new drug target for dementia

Researchers at King's College London have discovered how a molecular 'scaffold' which allows key parts of cells to interact, comes apart in dementia and motor neuron disease, revealing a potential new target for drug discovery.

4 Jun 2014

Metformin drug slows ageing and increases lifespan

A study by Belgian doctoral researcher Wouter De Haes (KU Leuven) and colleagues provides new evidence that metformin, the world's most widely used anti-diabetic drug, slows ageing and increases lifespan.

3 Jun 2014

Researchers create experimental blood test that determines BHI by gauging performance of mitochondria

Researchers at the University of Alabama at Birmingham School of Medicine have created an experimental blood test that, for the first time, determines a "Bioenergetic Health Index," or BHI, by gauging the performance of mitochondria, the cell's energy powerhouses.

30 May 2014

Edison Pharmaceuticals' EPI-743 granted orphan designation for Leigh syndrome in Japan

Edison Pharmaceuticals has announced that the Japanese Ministry of Health, Labor and Welfare (MHLW) has granted Orphan Designation to EPI-743 for the treatment of Leigh syndrome.

21 May 2014

Salk scientists explore earliest detectable changes in the brain that lead to schizophrenia

Using new stem cell technology, scientists at the Salk Institute have shown that neurons generated from the skin cells of people with schizophrenia behave strangely in early developmental stages, providing a hint as to ways to detect and potentially treat the disease early.

14 May 2014

Children with autism experience deficits in immune cell that protects against infection

Children with autism experience deficits in a type of immune cell that protects the body from infection. Called granulocytes, the cells exhibit one-third the capacity to fight infection and protect the body from invasion compared with the same cells in children who are developing normally.

9 May 2014

New study sheds light on mysterious gene that influences cardiovascular health

A new study from researchers at the University of Ottawa Heart Institute (UOHI), published today in Cell Reports, sheds light on a mysterious gene that likely influences cardiovascular health.

26 Apr 2014

Noval neuroimaging technique enables detailed insights into mitochondria

Reactive oxygen species are important intracellular signaling molecules, but their mode of action is complex: In low concentrations they regulate key aspects of cellular function and behavior, while at high concentrations they can cause "oxidative stress", which damages organelles, membranes and DNA.

25 Apr 2014

Researchers uncover Noxa and MCL-1 as potential targets for small cell lung cancers therapies

Approximately 15 percent of all lung cancers are small cell lung cancers (SCLC), which grow rapidly and often develop resistance to chemotherapy. However, researchers at Virginia Commonwealth University Massey Cancer Center have revealed new insights into the mechanisms leading to this resistance that may lead to improved therapies.

25 Apr 2014

Oxygen-rich postnatal atmosphere results in cell cycle arrest of cardiomyocytes

Scientific research at UT Southwestern Medical Center previously discovered that the newborn animal heart can heal itself completely, whereas the adult heart lacks this ability. New research by the same team today has revealed why the heart loses its incredible regenerative capability in adulthood, and the answer is quite simple - oxygen.

25 Apr 2014

Plymouth scientists receive MRC grant to lead new and effective therapies for Parkinson's disease

A team of scientists led by researchers at Plymouth University Peninsula Schools of Medicine and Dentistry, has received a grant from the Medical Research Council (MRC) for work which could lead to new and effective therapies for those with Parkinson's Disease.

23 Apr 2014

Study explains biological processes of malignant cancer cells

Cancer cells may be known for their uncontrollable growth and spread, but they also differ from normal tissue in another manner: how they produce energy.

22 Apr 2014

Researchers examine link between alcoholism and loss of muscle strength

Muscle weakness is a common symptom of both long-time alcoholics and patients with mitochondrial disease. Now researchers have found a common link: mitochondria that are unable to self-repair.

22 Apr 2014

Highly advanced imaging method helps to monitor rapid changes in glutathione redox potentials in live cells

In the April issue of Experimental Biology and Medicine a multidisciplinary research team led by Drs. Rex Gaskins and Paul Kenis in the Institute of Genomic Biology (IGB) on the campus of the University of Illinois Urbana-Champaign describe their recent work on subcellular redox homeostasis.

21 Apr 2014

Mitochondria News and Research

Single dose restores normal cellular signaling in mouse model of autism

Researchers demonstrate potential of retinoic acid in preventing type 2 diabetes complications

New genetic 'barcode' for malaria parasites could be used to track and contain spread of disease

Edison's EPI-743 receives FDA orphan drug designation for treatment of Leigh syndrome

Research findings on mTor, circadian rhythm, animal aging and FAT10 presented at AGE meeting

New gene involved in Parkinson's disease, find researchers

Researchers reveal potential new drug target for dementia

Metformin drug slows ageing and increases lifespan

Researchers create experimental blood test that determines BHI by gauging performance of mitochondria

Edison Pharmaceuticals' EPI-743 granted orphan designation for Leigh syndrome in Japan

Salk scientists explore earliest detectable changes in the brain that lead to schizophrenia

Children with autism experience deficits in immune cell that protects against infection

New study sheds light on mysterious gene that influences cardiovascular health

Noval neuroimaging technique enables detailed insights into mitochondria

Researchers uncover Noxa and MCL-1 as potential targets for small cell lung cancers therapies

Oxygen-rich postnatal atmosphere results in cell cycle arrest of cardiomyocytes

Plymouth scientists receive MRC grant to lead new and effective therapies for Parkinson's disease

Study explains biological processes of malignant cancer cells

Researchers examine link between alcoholism and loss of muscle strength

Highly advanced imaging method helps to monitor rapid changes in glutathione redox potentials in live cells

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