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Game theory can be used to identify potential flaws in current cancer treatment approaches

Game theory can be utilized to identify potential flaws in current cancer treatment approaches and suggest new strategies to improve outcomes in patients with metastatic cancer, according to a new article published online today by JAMA Oncology.

10 Aug 2018

Researchers study use of MRI-guided focused ultrasound to open blood-brain barrier

In the first such clinical trial in the United States, physician-scientists with the University of Maryland School of Medicine are investigating the use of MRI-guided focused ultrasound to open the blood-brain barrier.

10 Aug 2018

New insight could help develop novel and more effective antidepressant drugs

A new area in depression research suggests dysfunction in mitochondria -- the main source of energy for cells -- could lead to major depression.

10 Aug 2018

Researchers develop technology to create hybrid catalyst from rhodium and organic catalysts

A group of Japanese researchers has developed a technology to create a hybrid catalyst from simple-structured, commercially available rhodium and organic catalysts, which reduces chemical waste and produces molecules with high selectivity of an enantiomer, a pair of molecular structures that are non-superimposable mirror images of each other.

10 Aug 2018

New discovery could pave way for improved leukemia treatment

Previous research has revealed that patients with acute myeloid leukemia who also have a particular mutation in a gene called NPM1 have a higher rate of remission with chemotherapy. About one-third of leukemia patients possess this favorable mutation, but until now, how it helps improve outcomes has remained unknown.

9 Aug 2018

Lax oversight leaves surgery center regulators and patients in the dark

The first man died in April 2014. Another died later that month. Then on July 18 of that year, a woman was rushed to a hospital where she was told she was lucky to be alive.

9 Aug 2018

Study provides snapshot of mechanism behind cancer metastasis for the first time

Metastasis, or the formation of secondary tumors, is a leading contributor to the vast majority of deaths related to cancer.

9 Aug 2018

Researchers describe new class of potent inhibitors against amyloid plaques

Effective therapeutics to counteract the formation of amyloid plaques in Alzheimer's disease and type 2 diabetes are not yet available.

9 Aug 2018

Scientists find genetic marker that indicates a person's risk for tachycardia-induced cardiomyopathy

Scientists in Japan have found a potential marker to identify which people with abnormally fast heartbeats are at high risk of developing heart failure.

9 Aug 2018

Combination of arsenic and existing leukemia drug may combat cancer

Investigators have discovered that arsenic in combination with an existing leukemia drug work together to target a master cancer regulator.

9 Aug 2018

Study identifies key role of TLK1 and TLK2 enzymes in DNA replication

During cell growth, cells copy their DNA through a process called DNA replication. For this process to be accurate, the genetic and epigenetic information must be copied flawlessly.

9 Aug 2018

Study finds false negatives in common tests used to determine ROS1 status in lung cancer

Drugs like crizotinib are used to treat patients with ROS1-positive lung cancer. But which patients are ROS1-positive? A University of Colorado Cancer Center study published in the Journal of Thoracic Oncology shows that common laboratory tests used to determine ROS1 status all have inherent limitations that can lead to false-negative results.

9 Aug 2018

RNA and DNA sequencing platform matches broader swath of drugs to late-stage cancer patients

A comprehensive RNA and DNA sequencing platform benefits late-stage and drug-resistant multiple myeloma patients by determining which drugs would work best for them, according to results from a clinical trial published in JCO Precision Oncology in August.

9 Aug 2018

Proof-of-concept technology using nanoparticles could offer new approach for oral medications

Since the development of insulin to manage diabetes, pharmacists have longed to create an insulin pill. Past attempts have failed because insulin does not survive the harsh conditions of the gastro-intestinal system and cannot easily cross the GI wall.

9 Aug 2018

Atlas of the nervous system provides new clues about origin of neurological diseases

Researchers at Karolinska Institutet have created a systematic and detailed map of the cell types of the mouse nervous system.

9 Aug 2018

Cancer cells release biological 'drones' to assist in the fight against immune system

Cancer cells are more than a lump of cells growing out of control; they participate in active combat with the immune system for their own survival. Being able to evade the immune system is a hallmark of cancer.

9 Aug 2018

Scientists turn to C. elegans for new model of peripheral neuropathy

Studying transthyretin amyloidoses - a group of progressive nerve and cardiac degenerative diseases caused by the buildup of misfolded transthyretin proteins in the body - has long been hampered by the lack of animal models of the disease.

9 Aug 2018

Researchers modify nanoparticles to improve their uptake in gastrointestinal tract

Nanoparticles show great promise as diagnostic tools and drug delivery agents. The tiny particles, which scientists can modify with drugs, dyes or targeting molecules, can travel in the circulation and squeeze through small spaces into cells and tissues.

9 Aug 2018

New method evaluates effectiveness of interventions in mitigating spread of HIV

Using genetic sequencing to understand the evolutionary relationships among pathogens, an international team of researchers - including several from the Center for Drug Use and HIV/HCV Research at New York University - has developed a new method to determine how effective interventions are against the spread of infectious diseases like HIV.

9 Aug 2018

Gene considered as tumor promoter may also halt development of cancer, shows study

A gene that has for decades been considered a tumor promoter, the PLK1 gene, can also perform the exact opposite function: halting the development of cancer.

9 Aug 2018

Drugs News and Research

Game theory can be used to identify potential flaws in current cancer treatment approaches

Researchers study use of MRI-guided focused ultrasound to open blood-brain barrier

New insight could help develop novel and more effective antidepressant drugs

Researchers develop technology to create hybrid catalyst from rhodium and organic catalysts

New discovery could pave way for improved leukemia treatment

Lax oversight leaves surgery center regulators and patients in the dark

Study provides snapshot of mechanism behind cancer metastasis for the first time

Researchers describe new class of potent inhibitors against amyloid plaques

Scientists find genetic marker that indicates a person's risk for tachycardia-induced cardiomyopathy

Combination of arsenic and existing leukemia drug may combat cancer

Study identifies key role of TLK1 and TLK2 enzymes in DNA replication

Study finds false negatives in common tests used to determine ROS1 status in lung cancer

RNA and DNA sequencing platform matches broader swath of drugs to late-stage cancer patients

Proof-of-concept technology using nanoparticles could offer new approach for oral medications

Atlas of the nervous system provides new clues about origin of neurological diseases

Cancer cells release biological 'drones' to assist in the fight against immune system

Scientists turn to C. elegans for new model of peripheral neuropathy

Researchers modify nanoparticles to improve their uptake in gastrointestinal tract

New method evaluates effectiveness of interventions in mitigating spread of HIV

Gene considered as tumor promoter may also halt development of cancer, shows study

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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