Central Nervous System News and Research

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'Kidney-gene' plays role in the central nervous system and controls movement

The WT1 gene fulfills a central role in the development of a healthy, proper functioning kidney. Mutations in WT1 lead to impairments in kidney development and cause Wilms tumors, a pediatric kidney cancer.

1 Oct 2018

Early Parkinson’s disease patients wait too long before seeking medical attention

The time between diagnosis and the institution of symptomatic treatment is critical in the effort to find a cure for Parkinson's Disease.

29 Sep 2018

Researchers develop new mathematical technique to study brain waves

A U.S. Army Research Laboratory scientist has collaborated with a team of researchers from the University of North Texas to develop a new data processing technique that uses electroencephalogram, or EEG, time series variability as a measure of the state of the brain.

27 Sep 2018

Alnylam announces positive results from Phase 3 Study of givosiran for treating acute hepatic porphyria

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today positive topline results from the interim analysis of the ENVISION Phase 3 Study of givosiran, an investigational RNAi therapeutic targeting aminolevulinic acid synthase 1 for the treatment of acute hepatic porphyria.

27 Sep 2018

Obese mothers who underwent bariatric surgery can have safer deliveries

Obese mothers who lose weight through bariatric surgery can have safer deliveries. The positive effects are many, including fewer cesarean sections, infections, tears and hemorrhages, and fewer cases of post-term delivery or uterine inertia.

27 Sep 2018

New EU project aims to learn more about hormone-disrupting chemicals

Hormone-disrupting chemicals in our environment can affect early neurodevelopment in children, but little is known about the exact mechanisms for this interference. A new EU funded research project, coordinated from Karolinska Institutet, now aims to learn more and to develop better screening and testing tools.

26 Sep 2018

Study reveals changes in functioning of older individuals’ central nervous system

The central nervous system of older individuals responds to movement and initiates muscular contraction differently compared to young individuals.

26 Sep 2018

Risk-profiling can help improve preventive measures against HIV

That men who have sex with men run a greater risk of HIV than others has been known since the virus was discovered. However a thesis from Karolinska Institutet now shows that it is a small sub-group of these men who account for the greater part of the risk increase.

26 Sep 2018

Cerevance starts dosing in Phase I clinical trial of CVN424 for treatment of Parkinson's disease

Cerevance, a clinical-stage drug discovery and development company focused on brain diseases, today announced the start of dosing in a Phase I first-in-human clinical trial of CVN424, an oral compound being developed for symptomatic treatment of Parkinson's disease.

25 Sep 2018

Activation of glial cells causes inflammation in the brain of fibromyalgia patients

The causes of the difficult-to-treat pain syndrome fibromyalgia are largely unknown. Using PET brain imaging, researchers at Karolinska Institutet and Harvard University have now shown that glial cells - the central nervous system's immune cells - are activated in the brains of patients with fibromyalgia. The finding opens the way for new therapies

25 Sep 2018

Phase 1 and 2 clinical trials of entrectinib drug in ROS1-positive NSCLC show promising results

Results of phase 1 and phase 2 clinical trials of the drug entrectinib in ROS1-positive non-small cell lung cancer presented on the press program of the International Association for the Study of Lung Cancer 19th World Conference on Lung Cancer show a response rate of 77.4 percent for 53 patients evaluable for response, with median duration of response of 24.6 months.

25 Sep 2018

Alexion announces positive results from Phase 3 PREVENT study of Soliris in patients with NMOSD

Alexion Pharmaceuticals, Inc. today announced positive topline results from the Phase 3 PREVENT study of Soliris in patients with anti-aquaporin-4 auto antibody-positive neuromyelitis optica spectrum disorder.

24 Sep 2018

ADCETRIS drug receives approval in Japan as frontline treatment option for Hodgkin lymphoma

Seattle Genetics, Inc. today announced that its collaborator, Takeda Pharmaceutical Company Limited, has received approval from the Japanese Ministry of Health, Labour and Welfare for ADCETRIS (brentuximab vedotin) in combination with doxorubicin, vinblastine and dacarbazine as a frontline treatment option for CD30-positive Hodgkin lymphoma patients in Japan.

24 Sep 2018

CHMP recommends approval of Gilenya for treatment of multiple sclerosis in children, adolescents

Novartis today announced the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended approval of Gilenya (fingolimod) for the treatment of children and adolescents 10 to 17 years of age with relapsing remitting forms of multiple sclerosis.

24 Sep 2018

CHMP adopts positive opinion of Takeda’s ALUNBRIG for treatment of ALK+ non-small cell lung cancer

Takeda Pharmaceutical Company Limited today announced that the European Medicines Agency's Committee for Medicinal Products for Human Use has adopted a positive opinion, recommending the full approval of ALUNBRIG® as a monotherapy for the treatment of adult patients with anaplastic lymphoma kinase-positive advanced non-small cell lung cancer previously treated with crizotinib.

24 Sep 2018

Study offers solid link between visceral organs and brain’s reward, motivation system

A novel gut-to-brain neural circuit establishes the vagus nerve as an essential component of the brain system that regulates reward and motivation, according to research conducted at the Icahn School of Medicine at Mount Sinai and published September 20 in the journal Cell.

21 Sep 2018

Sea squirt model reveals key molecules in dopaminergic neuron differentiation

The human brain is exceedingly complex, consisting of various regions with particular functions and approximately 100 billion neurons. This complexity has presented a major challenge in understanding this organ and how it develops, particularly in view of the ethical issues associated with research on humans.

20 Sep 2018

Research finds physical connection between the brain's fluid reservoirs and meningeal lymphatics

PureTech Health plc, an advanced biopharmaceutical company developing novel medicines for dysfunctions of the Brain-Immune-Gut Axis, today notes the publication of research in Nature Neuroscience that identifies the physical connection between the brain's fluid reservoirs and the meningeal lymphatics, through which immune cells traffic out of the central nervous system.

18 Sep 2018

FDA approves Teva’s AJOVY injection for preventive treatment of migraine in adults

Teva Pharmaceutical Industries Ltd. today announced that the U.S. Food and Drug Administration has approved AJOVY injection for the preventive treatment of migraine in adults.

17 Sep 2018

Salk research in yeast leads to serendipitous finding about hypomyelinating leukodystrophy

Studying the fundamental aspects of biology can sometimes lead to unexpected findings that directly relate to human disease. In one of the latest examples of scientific serendipity, researchers from the Salk Institute found that an important quality control mechanism in baker's yeast is closely connected to hypomyelinating leukodystrophy, a debilitating disease found in children.

17 Sep 2018

Central Nervous System News and Research

'Kidney-gene' plays role in the central nervous system and controls movement

Early Parkinson’s disease patients wait too long before seeking medical attention

Researchers develop new mathematical technique to study brain waves

Alnylam announces positive results from Phase 3 Study of givosiran for treating acute hepatic porphyria

Obese mothers who underwent bariatric surgery can have safer deliveries

New EU project aims to learn more about hormone-disrupting chemicals

Study reveals changes in functioning of older individuals’ central nervous system

Risk-profiling can help improve preventive measures against HIV

Cerevance starts dosing in Phase I clinical trial of CVN424 for treatment of Parkinson's disease

Activation of glial cells causes inflammation in the brain of fibromyalgia patients

Phase 1 and 2 clinical trials of entrectinib drug in ROS1-positive NSCLC show promising results

Alexion announces positive results from Phase 3 PREVENT study of Soliris in patients with NMOSD

ADCETRIS drug receives approval in Japan as frontline treatment option for Hodgkin lymphoma

CHMP recommends approval of Gilenya for treatment of multiple sclerosis in children, adolescents

CHMP adopts positive opinion of Takeda’s ALUNBRIG for treatment of ALK+ non-small cell lung cancer

Study offers solid link between visceral organs and brain’s reward, motivation system

Sea squirt model reveals key molecules in dopaminergic neuron differentiation

Research finds physical connection between the brain's fluid reservoirs and meningeal lymphatics

FDA approves Teva’s AJOVY injection for preventive treatment of migraine in adults

Salk research in yeast leads to serendipitous finding about hypomyelinating leukodystrophy

Event guide: The 7th CNS Drug Delivery Summit eBook

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