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Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections

Lowering the transcription factor PU.1 reprograms microglia into a neuroprotective, lymphoid-like state that compacts amyloid, blocks tau spread, and preserves synapses in Alzheimer’s disease. Microglial CD28 signaling helps restrain inflammation, revealing a regulatory switch that may inform future immunotherapies targeting microglia rather than neurons.

6 Nov 2025

Scientists identify essential process that protects DNA integrity in reproductive cells

A team of scientists at the University of Seville has identified an essential process that protects DNA integrity in reproductive cells, providing new clues about how organisms avoid genetic defects during egg formation.

6 Nov 2025

Adolescents who experience migraines more likely to have high blood pressure

A nationwide study from the Hebrew University of Jerusalem has found that adolescents who experience migraines are three times more likely to have high blood pressure.

6 Nov 2025

Two main methods for discovering disease genes reveal distinct aspects of biology

The two main approaches for discovering disease genes reveal distinct aspects of biology, a new study shows. While both methods are widely used, the research found that they identify different genes, with major implications for drug development.

6 Nov 2025

Maternal type 1 diabetes confers a protective effect in children through epigenetic programming

Children with a family history of type 1 diabetes (T1D) have an increased risk of developing the disease.

6 Nov 2025

Global survey reveals struggles of young mothers living with advanced breast cancer

Nearly half of all women aged younger than 40 who live with advanced breast cancer have children under the age of 18, according to the first global survey to investigate the challenges these women face. Results from the survey were presented to the Advanced Breast Cancer Eighth International Consensus Conference (ABC8) today.

5 Nov 2025

World’s largest eye imaging and data resource expands across the UK

The world's largest collection of curated eye imaging and linked clinical data is expanding across the country, in an initiative led out of Moorfields Eye Hospital NHS Foundation Trust and UCL (University College London).

5 Nov 2025

Newly identified microglia subtype offers protection against Alzheimer’s disease

In Alzheimer's disease, the leading cause of dementia, microglia-the brain's immune defenders-can act as both protectors and aggressors, shaping how the disease progresses.

5 Nov 2025

New method brings hope for personalized treatment of inflammatory bowel disease

Patients with inflammatory bowel disease often have to wait a long time to find the right medicine. But the methods of a large interdisciplinary research team offer hope.

5 Nov 2025

EULAR develops first classification criteria for hemochromatosis arthropathy

EULAR - The European Alliance of Associations for Rheumatology - has developed the first classification criteria for hemochromatosis arthropathy (HA) from a unique derivation cohort using rigorous methodology.

5 Nov 2025

New genomic method unlocks hidden diversity in ocean microbes and viruses

A new method vastly improves on the existing approach for single-cell genetic sequencing, enabling scientists to read the genomes of individual cells and viral particles in the environment more quickly, efficiently, and cost-effectively.

5 Nov 2025

USC-led study advances understanding of prostate cancer genetics in Black men

New prostate cancer research from an international team led by the Center for Genetic Epidemiology at the Keck School of Medicine of USC has yielded discoveries that could improve screening and treatment for patients of African ancestry.

5 Nov 2025

Breakthrough study reveals how rabies virus uses few proteins to hijack cells

New antivirals and vaccines could follow the discovery by Australian researchers of strategies used by viruses to control our cells.

5 Nov 2025

Hidden cell structures reveal a common weakness in leukemia

A hidden structure inside the cell is rewriting how scientists understand leukemia. Beneath the microscope, what looked like disorder turned out to follow a simple physical rule – one that connects several major mutations behind the disease.

4 Nov 2025

Loud noise exposure worsens motor deficits in Parkinson’s disease model

In the development of Parkinson's disease, it may not be a good idea to turn the amp to 11. High-volume noise exposure produced motor deficits in a mouse model of early-stage Parkinson's disease, and established a link between the auditory processing and movement areas of the brain, according to a study published November 4th in the open-access journal PLOS Biology by Pei Zhang from the Huazhong University of Science and Technology in Wuhan, China, and colleagues.

4 Nov 2025

USC researchers map genetic architecture of the human corpus callosum

For the first time, a research team led by the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC has mapped the genetic architecture of a crucial part of the human brain known as the corpus callosum-the thick band of nerve fibers that connects the brain's left and right hemispheres.

4 Nov 2025

Survival patterns differ across types of early-onset dementia

The survival rates of people with early onset dementia-diagnosed before the age of 65-vary considerably by clinical type, but sex, age, family history and co-existing conditions aren't specific risk factors, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry.

4 Nov 2025