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Study offers hope for a new therapeutic option for patients with severe asthma

A new monoclonal antibody therapy shows promise in offering an alternative treatment for patients suffering from moderate-to-severe asthma. Research led by Michael E. Wechsler, MD, MMSc, director of the National Jewish Health Cohen Family Asthma Institute, found that itepekimab was safe and effective in a phase 2 trial published online today in the New England Journal of Medicine.

28 Oct 2021

Using fluvoxamine to treat COVID-19 patients reduces the need for prolonged hospitalization, trial shows

The results of a new randomized clinical trial, published in The Lancet Global Health, have demonstrated that using fluvoxamine to treat high-risk outpatients with early-diagnosed COVID-19 reduced the need for prolonged observation in an emergency setting or hospitalization, compared to a control group who received a placebo.

28 Oct 2021

A low-cost repurposed drug can save COVID-19 patients' lives

An inexpensive repurposed drug called fluvoxamine can save the lives of COVID-19 patients and cut hospital admissions by up to 30 per cent, says a study co-led by McMaster University.

27 Oct 2021

Cholesterol-lowering drugs not helpful in reducing COVID-related mortality or severity

In the worldwide effort to battle SARS-CoV-2, the virus that causes COVID-19, researchers have often turned to medications used as therapies for other conditions in the hopes of finding ones that either kill the coronavirus or lessen the impacts from its infection.

26 Oct 2021

Antidepressant offers no improvement in agitation for people with dementia, study shows

A drug used to treat agitation in people with dementia is no more effective than a placebo, and might even increase mortality, according to a new study.

22 Oct 2021

Researchers employ novel algorithm to identify candidate cancer drugs for pulmonary hypertension

By combining computational and experimental approaches, University of Pittsburgh School of Medicine and Prairie View A&M University researchers identified cancer drugs that show promise for treating pulmonary hypertension, or PH, a rare and incurable lung disease.

21 Oct 2021

Drug company pipelines are filling up with new molecules to help people lose weight

Drugs that promise to help people lose weight have had a checkered past, such as the infamous fen-phen that was pulled from the market in 1997 after reports of heart valve damage. But now, drug company pipelines are filling up with new molecules that aim to help people safely shed extra pounds, according to a cover story in Chemical & Engineering News, an independent news outlet of the American Chemical Society.

21 Oct 2021

Infrared light therapy may potentially benefit people with dementia

Infrared light therapy might have the potential to help people living with dementia, according to researchers.

19 Oct 2021

Phase 2 trial shows COVID-19 recombinant protein vaccine elicits promising immunogenicity responses

Researchers performed a large-scale, double-blind, placebo-controlled phase two trial to assess the efficacy, safety, and immune response elicited from vaccination with MVC-COV1901.

19 Oct 2021

Researchers illustrate the importance and value of sharing negative research results

In the era of "publish or perish," research results that disprove the hypothesis tested often go unpublished. In addition, many researchers who have been unable to reproduce results from other laboratories have found it difficult to publish their findings.

18 Oct 2021

FDA-approved drug encourages sensory neurons to regrow after injury

A spinal cord injury damages the lines of communication between the body and brain, impeding the signals that drive movement and sensation.

18 Oct 2021

Interferon beta-1a plus remdesivir not superior to remdesivir alone in hospitalized COVID-19 patients

A clinical trial has found that treatment with the immunomodulator interferon beta-1a plus the antiviral remdesivir was not superior to treatment with remdesivir alone in hospitalized adults with COVID-19 pneumonia.

18 Oct 2021

New trial shows vaginal laser therapy treatments may not work at all

This laser is supposed to rejuvenate vaginal tissue. But scientists say it’s no better than a placebo.

15 Oct 2021

Severe COVID-19 pneumonia patients with high ferritin show better outcomes after steroid treatment

During the entire pandemic, physicians treating patients with severe Covid-19 pneumonia continuously looked for hints and signs on what may enable patients to have better outcomes.

15 Oct 2021

Aspirin use daily by healthy adults could be harmful

Scientists determine if the daily use of aspirin prolongs a healthy life span that is defined as being free from dementia and physical disability.

14 Oct 2021

Oxytocin does not appear to overcome social deficits in children with ASD, study suggests

Regular doses of the hormone oxytocin do not appear to overcome deficits in social functioning among children with autism spectrum disorder (ASD), suggests a study funded by the National Institutes of Health.

13 Oct 2021

Novel vaccine demonstrates high efficacy for prevention of COVID-19

The clinical trial studied the efficacy of Novavax’s COVID-19 vaccine, NVX-CoV2373, and found it highly effective in preventing mild, moderate, and severe COVID-19 after full vaccination.

12 Oct 2021

Combination therapies are the most effective smoking cessation medicines, review finds

Combination therapies, particularly varenicline and nicotine replacement therapy (NRT) combined, are the most effective tobacco cessation pharmacotherapies, the largest review to examine the effectiveness and safety of electronic cigarettes (e-cigarettes) and medicines that people use to quit tobacco has found.

11 Oct 2021

Inactivated polio vaccine induces antibodies that block SARS-CoV-2 RNA synthesis

A new study introduces the possibility that the inactivated polio vaccine can elicit antibodies that inhibit SARS-CoV-2 nucleic acid synthesis.

10 Oct 2021

Oral and intranasal COVID-19 vaccines show promising results in hamster model

A new preprint discusses the protective effect of an oral adenovirus-vectored vaccine based on the SARS-CoV-2 spike against viral transmission and disease in hamsters.

8 Oct 2021

Placebo News and Research

Study offers hope for a new therapeutic option for patients with severe asthma

Using fluvoxamine to treat COVID-19 patients reduces the need for prolonged hospitalization, trial shows

A low-cost repurposed drug can save COVID-19 patients' lives

Cholesterol-lowering drugs not helpful in reducing COVID-related mortality or severity

Antidepressant offers no improvement in agitation for people with dementia, study shows

Researchers employ novel algorithm to identify candidate cancer drugs for pulmonary hypertension

Drug company pipelines are filling up with new molecules to help people lose weight

Infrared light therapy may potentially benefit people with dementia

Phase 2 trial shows COVID-19 recombinant protein vaccine elicits promising immunogenicity responses

Researchers illustrate the importance and value of sharing negative research results

FDA-approved drug encourages sensory neurons to regrow after injury

Interferon beta-1a plus remdesivir not superior to remdesivir alone in hospitalized COVID-19 patients

New trial shows vaginal laser therapy treatments may not work at all

Severe COVID-19 pneumonia patients with high ferritin show better outcomes after steroid treatment

Aspirin use daily by healthy adults could be harmful

Oxytocin does not appear to overcome social deficits in children with ASD, study suggests

Novel vaccine demonstrates high efficacy for prevention of COVID-19

Combination therapies are the most effective smoking cessation medicines, review finds

Inactivated polio vaccine induces antibodies that block SARS-CoV-2 RNA synthesis

Oral and intranasal COVID-19 vaccines show promising results in hamster model

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