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Hypothalamic ECM remodeling drives insulin resistance, contributing to obesity and diabetes

Researchers have discovered that remodeling of extracellular matrix (ECM) in the hypothalamus, specifically around AgRP neurons, drives insulin resistance and metabolic disease. Disrupting this ECM buildup improves insulin sensitivity and may be a promising treatment for obesity and diabetes.

19 Sep 2024

FORT-2 trial shows promising results for bladder cancer immunotherapy combination

Findings from the international FORT-2 clinical trial showed that a combination treatment including immunotherapy is safe and tolerable in patients with locally advanced or metastatic bladder cancer.

19 Sep 2024

Cardiovascular disease pathways associated with psoriasis, but not other immune-mediated diseases

A genetic connection between cardiovascular disease and psoriasis highlights shared inflammatory pathways, emphasizing the need for cardiovascular monitoring.

19 Sep 2024

Researchers uncover receptor that dampens sensory input

Signals in our brain are not always processed in the same way: Certain receptors modulate these mechanisms, influencing our mood, perception, and behavior in various ways. One of these is the 5-HT2A receptor, which has a recently discovered unique characteristic.

18 Sep 2024

Leptin variations may influence brain health and dementia development

New research is more closely linking obesity to dementia. Higher levels of leptin, a hormone that helps maintain normal body weight, is associated with better signal-transmitting brain white matter in middle-aged adults, according to a study by The University of Texas Health Science Center at San Antonio (UT Health San Antonio).

18 Sep 2024

Researchers discover how rare cell type controls scar tissue formation in spinal cord injuries

After a spinal cord injury, nearby cells quickly rush to action, forming protective scar tissue around the damaged area to stabilize and protect it.

18 Sep 2024

Study helps explain why having ApoE4 increases risk of neurodegeneration

A new study helps explain why having ApoE4—the gene variant most closely linked to Alzheimer's disease—increases the risk of neurodegeneration and white matter damage.

18 Sep 2024

Extended estrogen suppression treatment found safe for postmenopausal breast cancer patients

New evidence shows that extended estrogen suppression treatment using an aromatase inhibitors for hormone receptor-positive postmenopausal breast cancer is safe; it does not increase the risk of coronary artery calcification, a sign of active coronary atherosclerosis, as some prior studies had indicated.

18 Sep 2024

Study paves way for revolutionizing the management of muscle disorders

The type 1 ryanodine receptor (RyR1) is an important calcium release channel in skeletal muscles essential for muscle contraction.

18 Sep 2024

Newly discovered mechanism could revolutionize infertility care by promoting embryo implantation

A team from Kumamoto University has uncovered a new mechanism that could revolutionize infertility care by promoting embryo implantation.

18 Sep 2024

Researchers discover how oral cancer cells may block the body's immune response

Macquarie University researchers have discovered new information about how oral cancer cells may block the body's immune response. This could lead to better treatments for this aggressive disease.

18 Sep 2024

$1 million grant awarded to explore myelin repair mechanisms in multiple sclerosis

The National Multiple Sclerosis Society (USA) has awarded a grant of 1 million dollars to Dr. Isabel Pérez-Otaño, who leads the Plasticity and Remodeling of Neural Circuits laboratory at the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) of Elche.

18 Sep 2024

Impact of oxidative stress, gut, and diet on attention deficit hyperactivity disorder pathophysiology

Oxidative stress and gut microbiome interactions are key in ADHD pathogenesis, with diet playing a crucial role in managing symptoms and improving outcomes.

18 Sep 2024

Long COVID patients maintain robust immune memory two years after infection

Researchers discovered that SARS-CoV-2-specific T and B cells in long COVID patients are maintained for two years, similar to fully recovered individuals, offering insights into long-term immunity.

17 Sep 2024

Study reveals higher breast cancer mortality risk for black women across all tumor types

Breast cancer is the most diagnosed cancer among U.S. women and the second leading cause of cancer death.

17 Sep 2024

Telehealth app found to improve retention rates in opioid use disorder treatment

Patients who initiated treatment for opioid use disorder through a telehealth mobile app stayed with treatment at a greater rate over six months than those who started treatment in a physical clinic, a new study led by Oregon Health & Science University found.

17 Sep 2024

Post-treatment lifestyle choices influence long-term outcomes in breast cancer patients

Three studies led by Dana-Farber Cancer Institute researchers have encouraging implications for patients with breast cancer.

17 Sep 2024

Activation of PPARβ/δ-AMPK pathway shown to slow liver fibrosis development

A study led by Manuel Vázquez Carrera, group leader at the Diabetes and Associated Metabolic Diseases Networking Biomedical Research Centre (CIBERDEM) at the University of Barcelona, reveals advances in the understanding and treatment of liver fibrosis, a serious complication in the context of metabolic fatty liver disease, also known as MASLD (metabolic dysfunction-associated steatotic liver disease).

17 Sep 2024

Semaglutide vs. liraglutide: One-year weight loss efficacy in obesity and type 2 diabetes

Researchers compare the weight loss efficacy of injectable liraglutide and semaglutide.

17 Sep 2024

Cell rejuvenation atlas unveils master regulators of rejuvenation strategies

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 17 on September 9, 2024, entitled, "The cell rejuvenation atlas: leveraging network biology to identify master regulators of rejuvenation strategies."

16 Sep 2024

Receptor News and Research

Hypothalamic ECM remodeling drives insulin resistance, contributing to obesity and diabetes

FORT-2 trial shows promising results for bladder cancer immunotherapy combination

Cardiovascular disease pathways associated with psoriasis, but not other immune-mediated diseases

Researchers uncover receptor that dampens sensory input

Leptin variations may influence brain health and dementia development

Researchers discover how rare cell type controls scar tissue formation in spinal cord injuries

Study helps explain why having ApoE4 increases risk of neurodegeneration

Extended estrogen suppression treatment found safe for postmenopausal breast cancer patients

Study paves way for revolutionizing the management of muscle disorders

Newly discovered mechanism could revolutionize infertility care by promoting embryo implantation

Researchers discover how oral cancer cells may block the body's immune response

$1 million grant awarded to explore myelin repair mechanisms in multiple sclerosis

Impact of oxidative stress, gut, and diet on attention deficit hyperactivity disorder pathophysiology

Long COVID patients maintain robust immune memory two years after infection

Study reveals higher breast cancer mortality risk for black women across all tumor types

Telehealth app found to improve retention rates in opioid use disorder treatment

Post-treatment lifestyle choices influence long-term outcomes in breast cancer patients

Activation of PPARβ/δ-AMPK pathway shown to slow liver fibrosis development

Semaglutide vs. liraglutide: One-year weight loss efficacy in obesity and type 2 diabetes

Cell rejuvenation atlas unveils master regulators of rejuvenation strategies

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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