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Study identifies Δ42PD-1 as novel therapeutic target for hepatocellular carcinoma immunotherapy

HKUMed researchers at AIDS Institute, Department of Microbiology and Department of Surgery, School of Clinical Medicine, and School of Biomedical Sciences discover the role of an isoformic programmed cell death protein 1 (PD-1), namely Δ42PD-1, in suppressing the function of killer T cells, which is a type of immune cells essential for killing cancer cells among hepatocellular carcinoma (HCC) patients.

15 Dec 2022

Study uncovers previously unknown genetic cause of late-onset cerebellar ataxia

A new study published on Dec. 14, 2022 in the New England Journal of Medicine reports the identification of a previously unknown genetic cause of a late-onset cerebellar ataxia, a discovery that will improve diagnosis and open new treatment avenues for this progressive condition.

15 Dec 2022

Randomized trials demonstrate the safety of Ebola vaccine regimens in adults and children

Two randomized, placebo-controlled trials evaluating three Ebola vaccine administration strategies in adults and children found that all the regimens were safe in both age groups, according to results published today in the New England Journal of Medicine.

15 Dec 2022

Novel experimental system traces the development and longevity of plasma cells

Just as a fire department mobilizes in response to a reported fire, specialized immune cells in the body mobilize in response to the introduction of foreign substances known as antigens.

15 Dec 2022

Common kidney disease could be treated with existing medicines, new study shows

A serious condition that can cause the kidneys to suddenly stop working could be treated with existing medicines, a new study shows.

14 Dec 2022

Individuals with alcohol use disorder less likely to receive treatment for hepatitis C, study shows

A new study supported by the National Institutes of Health shows that individuals with alcohol use disorder (AUD) are less likely to receive antivirals for hepatitis C, despite current guidelines recommending antiviral treatment regardless of alcohol use.

14 Dec 2022

Four genetic mutations linked to progressive multifocal leukoencephalopathy

New research has confirmed a strong link between four genetic mutations and progressive multifocal leukoencephalopathy (PML), a rare but often fatal brain infection that can be triggered by dozens of FDA-approved drugs.

14 Dec 2022

Vaping may negatively affect pulmonary surfactant in the lungs, study shows

A recently published preclinical study by researchers at Lawson Health Research Institute and Western University's Schulich School of Medicine & Dentistry, show that vaping may negatively affect pulmonary surfactant in the lungs.

14 Dec 2022

Severity of COVID-19 in men may be due to the loss of Y chromosome

Men are at an increased risk of a severe bout of COVID-19 compared to women. Researchers at Uppsala University have now shown that this may be due to loss of the Y chromosome in part of their white blood cells.

14 Dec 2022

Study finds a novel therapeutic target for prevention and treatment of gout

Many Americans think of gout as a disease from a bygone era, akin to rickets or scurvy. The condition commonly afflicted the rich and royal, including American historical figures such as Benjamin Franklin and Thomas Jefferson.

14 Dec 2022

Flexible assemblies of nerve cells appear to be key to successful episodic memory

For the first time, scientists have recorded human nerve cells firing together in flexible assemblies, a process that appears necessary to successfully encode long-term memories, a study led by UT Southwestern researchers reports.

14 Dec 2022

Updated guidelines seek to improve transparency and utility in clinical trial reporting

In a global study of outcome reporting in clinical trials, a research team at The Hospital for Sick Children (SickKids) has issued updated guidelines on what should be included in all trial protocols and published clinical trial reports, with the goal to improve their transparency and utility.

14 Dec 2022

Major treatment advance revealed for adults with newly diagnosed B lineage acute lymphoblastic leukemia

Late-breaking research reveals a major treatment advance for adults with newly diagnosed B lineage acute lymphoblastic leukemia (ALL).

14 Dec 2022

People with cocaine- and opioid-use disorders infected with COVID-19 have greater risk of endocarditis

People diagnosed with cocaine- and opioid-use disorders are more susceptible to developing endocarditis, a condition that damages the lining of the heart valves and chambers, according to research from the Case Western Reserve University School of Medicine and National Institute on Drug Abuse, part of the National Institutes of Health.

14 Dec 2022

Subcutaneous fat protects against brain inflammation in females

Females' propensity to deposit more fat in places like their hips, buttocks and the backs of their arms, so-called subcutaneous fat, is protective against brain inflammation, which can result in problems like dementia and stroke, at least until menopause, scientists report.

14 Dec 2022

The therapeutic effects and safety of psychedelics

Psychedelics are reported to have rapid-onset and long-lasting therapeutic benefits after a single or few doses.

14 Dec 2022

Scientists provide evidence of the positive effects of alcohol abstinence in advanced liver cirrhosis

Complete abstinence from alcohol is considered a cornerstone in the treatment of patients with alcohol-related liver disease. It has not yet been sufficiently researched whether this measure can still improve the prognosis even in the case of advanced liver cirrhosis.

14 Dec 2022

Extreme temperatures increase risk of heart failure deaths

According to a new study performed, exposure to extremely hot or cold temperatures raises a heart disease patient’s risk of dying.

14 Dec 2022

States challenge Biden to lower drug prices by allowing imports from Canada

The Biden administration is facing mounting pressure from states to let them import medicine from Canada to help lower prescription drug costs.

14 Dec 2022

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

Researchers have characterised prostate cancer cell dynamics at a single-cell resolution across the timespan of the disease – from its beginning to the point of androgen independence, where the tumour no longer responds to hormone deprivation therapy.

14 Dec 2022

Medicine News and Research

Study identifies Δ42PD-1 as novel therapeutic target for hepatocellular carcinoma immunotherapy

Study uncovers previously unknown genetic cause of late-onset cerebellar ataxia

Randomized trials demonstrate the safety of Ebola vaccine regimens in adults and children

Novel experimental system traces the development and longevity of plasma cells

Common kidney disease could be treated with existing medicines, new study shows

Individuals with alcohol use disorder less likely to receive treatment for hepatitis C, study shows

Four genetic mutations linked to progressive multifocal leukoencephalopathy

Vaping may negatively affect pulmonary surfactant in the lungs, study shows

Severity of COVID-19 in men may be due to the loss of Y chromosome

Study finds a novel therapeutic target for prevention and treatment of gout

Flexible assemblies of nerve cells appear to be key to successful episodic memory

Updated guidelines seek to improve transparency and utility in clinical trial reporting

Major treatment advance revealed for adults with newly diagnosed B lineage acute lymphoblastic leukemia

People with cocaine- and opioid-use disorders infected with COVID-19 have greater risk of endocarditis

Subcutaneous fat protects against brain inflammation in females

The therapeutic effects and safety of psychedelics

Scientists provide evidence of the positive effects of alcohol abstinence in advanced liver cirrhosis

Extreme temperatures increase risk of heart failure deaths

States challenge Biden to lower drug prices by allowing imports from Canada

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

Everything there is to know about biosimilars eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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