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Mosaic loss of Y chromosome increases risk for heart failure and cardiac fibrosis in men

Why a condition that frequently occurs in aging men, in which an increasing number of hematopoietic cells display a loss of the Y chromosome, is associated with increased risk of mortality and age-related diseases is now a little clearer, thanks to work in mice.

15 Jul 2022

MINAR2 gene mutations cause progressive hearing loss

Researchers at the John T. Macdonald Department of Human Genetics and the John P. Hussman Institute for Human Genomics at the University of Miami Miller School of Medicine have found that inherited mutations in the MINAR2 gene caused deafness in four families. The gene variation mostly affects the inner ear hair cells, which are critical to hearing.

14 Jul 2022

SARS-Arena reveals conserved parts of viral proteins that cause COVID-19

Vaccines may need to dig a little deeper to stop SARS-CoV-2. Rice University researchers are providing a new shovel.

14 Jul 2022

Study reveals a new molecular perspective to the cause of Gaucher's disease

A study by researchers at Baylor College of Medicine, the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and collaborating institutions is the first to associate neuronal activity to the levels of sphingolipids, a type of fat, in brain cells.

13 Jul 2022

Surveillance program for high risk patients aids in early detection of pancreatic cancer

Surveillance programs for people at high risk of developing pancreatic cancers can help detect precancerous conditions and cancers early, when they are most treatable, according to a new multicenter study directed by experts at the Johns Hopkins Kimmel Cancer Center.

13 Jul 2022

Study reveals tiny gene fragments as crucial new players in retinal development and vision

Researchers at the Centre for Genomic Regulation in Barcelona reveal that Srrm3 is a master regulator gene crucial for the development of photoreceptors, cells in the back of the retina which capture and process light, sending signals to the brain that enable vision.

13 Jul 2022

Evolutionary characteristics of the SARS-CoV-2 Omicron variant

Researchers compared the mutations in the SARS-CoV-2 Omicron variant with others to highlight their evolutionary differences.

13 Jul 2022

The impact of the SARS-CoV-2 spike A222V mutation on viral infection

Researchers analyzed the structural function of the genetic background of SARS-CoV-2 in the appearance and persistence of A222V spike mutation.

13 Jul 2022

Detection of SARS-CoV-2 variants in aircraft wastewater

Researchers detect SARS-CoV-2 variants in the wastewater of aircrafts

12 Jul 2022

How may the genetic differences observed in the current monkeypox virus outbreak impact immune responses induced by VACV vaccines?

Researchers assessed the impact of the vaccinia virus vaccine on the immune response against the monkeypox virus.

12 Jul 2022

Researchers report a non-canonical RNA secondary structure present in monkeypox virus variants

Researchers described the evolutionary profile of the monkeypox virus.

12 Jul 2022

Scientists investigate impact of SARS-CoV-2 RBD mutations across variants

In a recent study posted to the medRxiv* pre-print server, Australian researchers comprehensively investigated the impact of 39 receptor-binding-domain (RBD) mutations in six severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and variants of interest (VOIs).

12 Jul 2022

Study assesses the potential of plant secondary metabolites as potential anti-COVID-19 agents

A new study has focused on identifying plant secondary metabolites (PSM) having a higher affinity for S-RBD of SARS-CoV-2.

11 Jul 2022

The interplay of family history and genome-wide polygenic risk scores across 24 common diseases

A new study has investigated the interplay of FH and genome-wide PRS

11 Jul 2022

Clinical trial examining the combination of atezolizumab and chemoradiation for patients with limited-stage SCLC reaches accrual

The NRG Oncology/Alliance clinical trial NRG-LU005, examining the addition of the immunotherapy drug atezolizumab combined with chemoradiation for patients with limited-stage small cell lung cancer (SCLC) recently reached the trial's accrual goal of 506 patients.

8 Jul 2022

Disrupting genes in the yeast Pichia pastori to increase its secretory production of useful proteins

A collaboration including researchers from Kobe University, University of Tokyo and Tohoku University has successfully identified and disrupted genes in the yeast Pichia pastoris (1) in order to increase its secretory production of useful proteins (2).

8 Jul 2022

Mutation News and Research

Mosaic loss of Y chromosome increases risk for heart failure and cardiac fibrosis in men

MINAR2 gene mutations cause progressive hearing loss

SARS-Arena reveals conserved parts of viral proteins that cause COVID-19

Study reveals a new molecular perspective to the cause of Gaucher's disease

Surveillance program for high risk patients aids in early detection of pancreatic cancer

Study reveals tiny gene fragments as crucial new players in retinal development and vision

Evolutionary characteristics of the SARS-CoV-2 Omicron variant

The impact of the SARS-CoV-2 spike A222V mutation on viral infection

Detection of SARS-CoV-2 variants in aircraft wastewater

How may the genetic differences observed in the current monkeypox virus outbreak impact immune responses induced by VACV vaccines?

Researchers report a non-canonical RNA secondary structure present in monkeypox virus variants

Scientists investigate impact of SARS-CoV-2 RBD mutations across variants

Study assesses the potential of plant secondary metabolites as potential anti-COVID-19 agents

The interplay of family history and genome-wide polygenic risk scores across 24 common diseases

Clinical trial examining the combination of atezolizumab and chemoradiation for patients with limited-stage SCLC reaches accrual

Disrupting genes in the yeast Pichia pastori to increase its secretory production of useful proteins

The putative impact of vitamin D receptor gene polymorphisms on SARS-CoV-2 infection among different variants

What is the monkeypox transmission risk in metropolitan areas?

Novel gene-based therapies for sickle cell disease rely on finding the right mouse for the job

SARS-CoV-2 RBD vulnerability discovered - target for antibodies against variants

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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