Protein C News and Research

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Removal of a critical enzyme may help cases of sepsis finds research

Scientists at the University of California San Diego School of Medicine have shown that removal of an enzyme called the PH domain Leucine-rich repeat Protein Phosphatase 1 (PHLPP1) could help laboratory mice with sepsis in a model they had created for their experiment. The study titled, “PHLPP1 counter-regulates STAT1-mediated inflammatory signalling,” was published this week in the journal eLife.

15 Aug 2019

KIT researchers develop new method to predict protein structure

Proteins are biological high-performance machines. They can be found in every cell and play an important role in human blood coagulation or as main constituents of hairs or muscles.

14 Aug 2019

Chlamydia vaccine shows promise after a successful clinical trial

A vaccine against the sexually transmitted infection (STI) chlamydia is now a substantial step closer to reality after successfully passing its Phase 1 clinical trial.

14 Aug 2019

Link between endocannabinoids and exercise could lead to better treatment for depression

Researchers know exercise improves mood for people with depression, but there are still questions about exactly how it makes people feel better.

14 Aug 2019

Resurrecting protein ancestors yields evolutionary insights into their role in human cells

"Resurrecting" the ancestors of key proteins yields evolutionary insights into their role in human cells and in most cancers, a new study finds.

14 Aug 2019

High troponin levels after exercise predict risk of cardiovascular events

Regular exercise is healthy and reduces the risk of cardiovascular disease. Nevertheless, it appears that prolonged and/or intensive exercise can lead to an increase in cardiac biomarkers in the blood, such as the regulatory protein troponin. Troponin is a protein that is present in every heart muscle cell.

14 Aug 2019

Researchers identify molecular switch that impacts immune responses to viral infections

Walter and Eliza Hall Institute researchers have identified a molecular switch that impacts immune responses to viral infections, and whether or not protective antibodies are produced.

14 Aug 2019

Scientists demonstrate an in vitro kidney model

Kidneys work to constantly filter blood and remove toxins from the body. Conditions such as chronic kidney disease are characterized by a reduced ability to perform this essential function.

14 Aug 2019

Deadly protein combination reveals new drug targets for viral infections

New research from Cornell University details how two highly lethal viruses have greater pathogenic potential when their proteins are combined.

14 Aug 2019

Researchers identify new transmembrane protein as chloride ion channel

In the human body the salt content of cells and their surrounding is regulated by sophisticated transport systems.

14 Aug 2019

Penn State researcher awarded NSF grant to model cell disorder in the heart

On average, the human heart beats anywhere from 60 to 80 times per minute - that's almost 42 million times a year. Each beat consists of billions of cells working together, using their protein channels to pass electrical signals across the muscle.

14 Aug 2019

Roswell Park receives more than $15 million in grants for cancer research

Roswell Park Comprehensive Cancer Center researchers have received more than a dozen recent grant awards totaling more than $15.4 million.

14 Aug 2019

Study sheds light on likely conserved functions of gammaherpesvirus microRNAs

The discovery of thousands of host mRNAs targeted by gammaherpesvirus microRNAs (miRNAs) could shed light on the biology of gammaherpesviruses and how these pathogens establish lifelong infections, according to a study published August 8 in the open-access journal PLOS Pathogens by Scott Tibbetts of the University of Florida, and colleagues.

From PLOS ONE 13 Aug 2019

Sartorius Stedim Biotech announces launch of new services for mammalian cell bank manufacturing

Sartorius Stedim Biotech (SSB), a leading partner of the biopharmaceutical industry, today announced the launch of new services for mammalian cell bank manufacture under GMP conditions.

From Sartorius 13 Aug 2019

Bile pigment may play an unexpected role in protecting the brain

In studies in mice, Johns Hopkins Medicine researchers report they have found that bilirubin, a bile pigment most commonly known for yellowing the skin of people with jaundice, may play an unexpected role in protecting brain cells from damage from oxidative stress.

From Johns Hopkins Medicine 13 Aug 2019

Newborn mouse model yields clues to cause of devastating gut disease in anemic preemies

Physicians have long suspected that red blood cell transfusions given to premature infants with anemia may put them in danger of developing necrotizing enterocolitis, or NEC, a potentially lethal inflammatory disease of the intestines.

From Johns Hopkins Medicine 13 Aug 2019

Beta amyloid structure mapped in new Alzheimer’s research

In search of a possible cure for Alzheimer’s disease (AD), scientists have found out the molecular structure of a type of protein called beta amyloid that accumulates within brain cells, eventually killing them. This could help understand how to prevent these abnormal proteins from forming, leading to a cure or treatment for this killer disease.

13 Aug 2019