Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

FDA expands approval of Vertex' cystic fibrosis medicine to treat children aged 12 to <24 months

Vertex Pharmaceuticals Incorporated today announced the U.S. Food and Drug Administration approved KALYDECO® (ivacaftor) to include use in children with cystic fibrosis ages 12 to <24 months who have at least one mutation in their cystic fibrosis transmembrane conductance regulator gene that is responsive to KALYDECO based on clinical and/or in vitro assay data.

16 Aug 2018

Penn researchers develop first mouse model of idiopathic pulmonary fibrosis

The biggest hurdle to finding effective therapies for idiopathic pulmonary fibrosis (IPF) – a life-threatening condition in which the lungs become scarred and breathing is increasingly difficult – has been the inability to fully model the disease in animals, limiting the ability to observe and understand the disease.

16 Aug 2018

Hearts of newborn piglets can completely heal after heart attacks

While pigs still cannot fly, researchers have discovered that the hearts of newborn piglets do have one remarkable ability. They can almost completely heal themselves after experimental heart attacks.

15 Aug 2018

Clinical study suggests new treatment direction for head and neck cancer in heavy smokers

Patients with a greater than 10 pack/year history of smoking tend to develop an especially dangerous form of head and neck squamous cell cancer for which prognosis remains poor and treatments have changed little during the past two decades.

14 Aug 2018

Scientists uncover mechanisms responsible for development of fibrosis

Idiopathic pulmonary fibrosis is an incurable lung disease of unknown origin with limited treatment options. Research suggests that the signaling molecule WNT5A plays a key role in the pathogenic process.

10 Aug 2018

Researchers find potential therapeutic target for treating obesity and diabetes

A newly published study by researchers from the University of Colorado School of Medicine has identified a potential therapeutic target for treating obesity and diabetes.

10 Aug 2018

Silencing of GULP1 gene expression plays important role in ovarian carcinogenesis

Johns Hopkins researchers in collaboration with Insilico Medicine, a biotechnology company based in Rockville Maryland, identify that silencing of the GULP1 gene expression by methylation plays an important role in ovarian carcinogenesis.

7 Aug 2018

Study could help explain why Asians often develop diabetes at a lower body weight

A new UC San Francisco study has discovered a key biological difference in how people of European and Chinese descent put on weight -- a finding that could help explain why Asians often develop type 2 diabetes at a much lower body weight than Caucasians.

7 Aug 2018

Doxorubicin drug causes heart toxicity by disrupting the immune system

Doxorubicin is a chemotherapy drug widely used in ovarian, bladder, lung, thyroid and stomach cancers, but it carries a harmful side effect. The drug causes a dose-dependent heart toxicity that can lead to congestive heart failure.

7 Aug 2018

Research: Having large muscle size could 'outweigh' poor muscle quality in CKD patients

The size of muscles in patients suffering from Chronic Kidney Disease could be more important to maintaining good physical performance than muscle quality, new research has shown.

6 Aug 2018

Cystic fibrosis impacts directly on intrauterine growth, shows research

New research, published in Thorax, funded by the Cystic Fibrosis Trust has shown that babies with cystic fibrosis are born weighing less than babies without the condition, even allowing that they are more likely to be born prematurely.

3 Aug 2018

Discovery of new epithelial lung cell type may affect cystic fibrosis therapy

Scientists have discovered a new type of cell in the human respiratory tract called the pulmonary ionocyte, and linked it to cystic fibrosis.

3 Aug 2018

Mechanical engineer receives NIH grant to study various aspects of cell group behavior

Researchers have thought that cancer begins when a single cell goes rogue in the body, then begins to grow and multiply.

3 Aug 2018

Digestive hormone influences pancreatic cancer growth and spread

A high-fat diet may promote the growth of pancreatic cancer independent of obesity because of the interaction between dietary fat and cholecystokinin, a digestive hormone.

3 Aug 2018

Highly inflamed vascular plaques associated with progressive liver disease

The world's rising obesity epidemic is associated with a broad spectrum of ailments including atherosclerosis and non-alcoholic fatty liver disease.

2 Aug 2018

Mologic begins clinical trial to evaluate urine-based diagnostic for cystic fibrosis

Mologic Ltd, a developer of powerful, personalized diagnostics to improve the lives of patients, today announced that it has commenced a clinical trial to evaluate the Company's urine-based diagnostic, HeadsUp, in monitoring pulmonary exacerbation in cystic fibrosis patients.

2 Aug 2018

Pioneering research takes major step forward in the fight against cystic fibrosis

The fight against cystic fibrosis has taken a major step forward, with pioneering research by University of Adelaide scientists showing that cells causing the debilitating genetic disorder could be successfully replaced with healthy ones.

2 Aug 2018

Breakthrough in stem cell research could lead to cure for cystic fibrosis

Researchers have successfully proved that gene therapy can be used to convert adult stem cells into functioning lung cells for the treatment of cystic fibrosis

2 Aug 2018

Study reveals early signs of cardiac impairment in patients with newly diagnosed lupus

Cardiovascular disease is a leading cause of death in patients with lupus, a systemic autoimmune disease. In a new study in Arthritis & Rheumatology—a journal published by Wiley on behalf of the American College of Rheumatology—imaging tests revealed signs of cardiac impairment in patients newly diagnosed with lupus, even before any symptoms of chest discomfort.

2 Aug 2018

Researchers discover new, rare type of cell in the human airway

In separate studies published online in Nature on Aug. 1, two independent research teams report the discovery of a new, rare type of cell in the human airway.

2 Aug 2018

Fibrosis News and Research

Further Reading

FDA expands approval of Vertex' cystic fibrosis medicine to treat children aged 12 to <24 months

Penn researchers develop first mouse model of idiopathic pulmonary fibrosis

Hearts of newborn piglets can completely heal after heart attacks

Clinical study suggests new treatment direction for head and neck cancer in heavy smokers

Scientists uncover mechanisms responsible for development of fibrosis

Researchers find potential therapeutic target for treating obesity and diabetes

Silencing of GULP1 gene expression plays important role in ovarian carcinogenesis

Study could help explain why Asians often develop diabetes at a lower body weight

Doxorubicin drug causes heart toxicity by disrupting the immune system

Research: Having large muscle size could 'outweigh' poor muscle quality in CKD patients

Cystic fibrosis impacts directly on intrauterine growth, shows research

Discovery of new epithelial lung cell type may affect cystic fibrosis therapy

Mechanical engineer receives NIH grant to study various aspects of cell group behavior

Digestive hormone influences pancreatic cancer growth and spread

Highly inflamed vascular plaques associated with progressive liver disease

Mologic begins clinical trial to evaluate urine-based diagnostic for cystic fibrosis

Pioneering research takes major step forward in the fight against cystic fibrosis

Breakthrough in stem cell research could lead to cure for cystic fibrosis

Study reveals early signs of cardiac impairment in patients with newly diagnosed lupus

Researchers discover new, rare type of cell in the human airway

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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