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Genetic key to milder COVID: Certain genes slash severity and death risk in older men

Study found that certain genetic variants in the IL1RN gene significantly reduce COVID-19-related inflammation and mortality in patients, with notable improvements observed in older men carrying specific single-nucleotide variants.

19 Mar 2024

Study uncovers how APOBEC enzymes drive cancer mutations

A research team led by the University of California, Irvine has discovered the key role that the APOBEC3A and APOBEC3B enzymes play in driving cancer mutations by modifying the DNA in tumor genomes, offering potential new targets for intervention strategies.

18 Mar 2024

Study reveals the inner workings of gene mutations linked to ultra-rare syndrome

A team from the University of Ottawa's Faculty of Medicine has completed an exciting new study that reveals the inner workings of gene mutations that result in an ultra-rare syndrome with fewer than 100 reported cases since its first description in the early 1960s.

18 Mar 2024

Machine learning models to predict age from brain transcriptome changes

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 5, entitled, "Genome-wide transcriptome profiling and development of age prediction models in the human brain."

15 Mar 2024

Newly discovered adhesion GPCR mayo controls midgut development in Drosophila

Adhesion GPCRs belong to the large family of G protein-coupled receptors (GPCRs). There are about 700 variants in humans, which are responsible for sensory impressions, hormonal cycles, controlling the cardiovascular system and more.

15 Mar 2024

Rapid, easy-to-use diagnostic test could save more lives from melioidosis

Globally, more than half of patients die after infection with the neglected tropical disease, melioidosis, often before they are diagnosed.

13 Mar 2024

Atypical brain connections linked to ADHD symptoms

Researchers at the National Institutes of Health (NIH) have discovered that symptoms of attention-deficit/hyperactivity disorder (ADHD) are tied to atypical interactions between the brain's frontal cortex and information processing centers deep in the brain.

13 Mar 2024

Ricoh and ERS Genomics enter into CRISPR/Cas9 license agreement

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From ERS Genomics 13 Mar 2024

Tracing Monkeypox virus: Leveraging ancient orangutan DNA to investigate the 1965 Rotterdam Zoo outbreak

Ancient DNA analysis of museum-preserved orangutan teeth reveals the cause of the 1965 zoo outbreak in the Netherlands as monkeypox virus (MPXV) infections, demonstrating the power of museomic techniques in tracing historic viral transmissions.

12 Mar 2024

Protein Kdm1a plays a crucial role in preserving neuronal identity, study shows

Epigenetic processes allow different cell types to emerge from a single genome. Throughout development, cells differentiate and acquire distinct characteristics by expressing the same genome in different ways.

12 Mar 2024

MIT researchers develop new method to quickly screen cancer-associated genetic mutations

Tumors can carry mutations in hundreds of different genes, and each of those genes may be mutated in different ways - some mutations simply replace one DNA nucleotide with another, while others insert or delete larger sections of DNA.

12 Mar 2024

Groundbreaking study unveils sex-specific genetic influences on blood pressure

Genetic heterogeneity of blood pressure (BP) effects between sexes.

12 Mar 2024

Study unravels FOXO1's influence on blood vessel development

The human vascular system, a complex network of blood vessels, plays an essential role in maintaining health. Understanding the molecular mechanisms underlying vascular development is important for tackling age-related disorders.

9 Mar 2024

Unveiling the molecular mechanism responsible for crossover interference during meiosis

Movies such as 'X-Men,' 'Fantastic Four,' and 'The Guardians,' which showcase vibrant mutant heroes, have captivated global audiences.

7 Mar 2024

Breakthrough in CRISPR delivery promises safer gene editing

Recent research in PNAS highlights advancements in non-viral, cell-specific delivery methods for CRISPR-Cas systems, emphasizing their potential to enhance research and gene therapy applications by minimizing risks associated with off-target effects and improving targeted delivery.

7 Mar 2024

Proteins regulating plasminogen-plasmin levels can help predict COVID-19 severity

The global impact of the COVID-19 pandemic on healthcare systems has been significant. The sudden surge in infected cases overwhelmed hospitals and disrupted routine healthcare services, thus further worsening public health.

7 Mar 2024

"Copy-paste" genetic mechanism increases the genetic diversity of malaria parasite

By dissecting the genetic diversity of the most deadly human malaria parasite – Plasmodium falciparum – researchers at EMBL's European Bioinformatics Institute (EMBL-EBI) have identified a mechanism of 'copy-paste' genetics that increases the genetic diversity of the parasite at accelerated time scales.

7 Mar 2024

Inherited genetic factors may predict elevated risk of new cancers among childhood cancer survivors

Common inherited genetic factors that predict cancer risk in the general population may also predict elevated risk of new cancers among childhood cancer survivors, according to a study led by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health.

7 Mar 2024

Mass spectrometry and glycobiology - what are the genetic applications?

In this new episode of the omg OMx podcast, Kate Stumpo speaks to Chris Taron about his experience in glycobiology, the use of mass spectrometry in that field, and the implications for genetic research.

From Bruker Daltonics 7 Mar 2024

Gut bacteria strains could be the key to predicting cancer treatment success

Researchers discovered that gut microbiota strains can predict the effectiveness and adverse effects of immune checkpoint blockade (ICB) therapy in rare cancer patients.

6 Mar 2024

Genome News and Research

Genetic key to milder COVID: Certain genes slash severity and death risk in older men

Study uncovers how APOBEC enzymes drive cancer mutations

Study reveals the inner workings of gene mutations linked to ultra-rare syndrome

Machine learning models to predict age from brain transcriptome changes

Newly discovered adhesion GPCR mayo controls midgut development in Drosophila

Rapid, easy-to-use diagnostic test could save more lives from melioidosis

Atypical brain connections linked to ADHD symptoms

Ricoh and ERS Genomics enter into CRISPR/Cas9 license agreement

Tracing Monkeypox virus: Leveraging ancient orangutan DNA to investigate the 1965 Rotterdam Zoo outbreak

Protein Kdm1a plays a crucial role in preserving neuronal identity, study shows

MIT researchers develop new method to quickly screen cancer-associated genetic mutations

Groundbreaking study unveils sex-specific genetic influences on blood pressure

Study unravels FOXO1's influence on blood vessel development

Unveiling the molecular mechanism responsible for crossover interference during meiosis

Breakthrough in CRISPR delivery promises safer gene editing

Proteins regulating plasminogen-plasmin levels can help predict COVID-19 severity

"Copy-paste" genetic mechanism increases the genetic diversity of malaria parasite

Inherited genetic factors may predict elevated risk of new cancers among childhood cancer survivors

Mass spectrometry and glycobiology - what are the genetic applications?

Gut bacteria strains could be the key to predicting cancer treatment success

Genetics & Genomics - Second Edition eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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