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Scientists uncover novel process by which APOL1 gene contributes to renal disease

A Children's National Health System research team has uncovered a novel process by which the gene APOL1 contributes to renal disease, according to a paper published November 18 in the Journal of the American Society of Nephrology.

18 Nov 2016

New webinar provides opportunity to learn background of MicroScale Thermophoresis

Live Webinar for Users and Interested Scientists

16 Nov 2016

Researchers identify mechanism of how circadian clocks in neurons encode daily rhythms of excitability

Molecular clocks in cells throughout the body control many physiologic changes in a 24-hour day/night circadian rhythm -- among them the timing of sleep and wakefulness.

14 Nov 2016

Ludwig study shows how experimental drug can reverse effects of suppressive immune cells

A Ludwig Cancer Research study shows that an experimental drug currently in clinical trials can reverse the effects of troublesome cells that prevent the body's immune system from attacking tumors.

9 Nov 2016

Certain anti-diabetic drugs can switch off molecule that plays key role in inflammatory diseases

A molecule thought to play a key role in some inflammatory diseases can be switched off by two widely used medicines, new research has shown.

9 Nov 2016

Biological scientists provide new insight into fundamental aspect of human heart function

AN INTERNATIONAL team of scientists have provided new insight into the Frank-Starling mechanism; a fundamental aspect of human heart function.

8 Nov 2016

New treatment with therapeutic short interfering RNA could help thwart cancer

In the fight against cancer, doctors dish out combination-blows of surgery, chemotherapy and other drugs to beat back a merciless foe. Now, scientists have taken early steps toward adding a stinging punch to clinicians' repertoire.

7 Nov 2016

Fresh insights into immune cell could signal new approach to treating life-threatening lung condition

Fresh insights into a life-threatening lung condition triggered by blood poisoning could signal a new approach to treating the disease, researchers found.

3 Nov 2016

Genetic mutation confers risk for development of Parkinson's disease earlier than usual

A collaboration of 32 researchers in seven countries, led by scientists at Mayo Clinic's campus in Florida, has found a genetic mutation they say confers a risk for development of Parkinson's disease earlier than usual.

3 Nov 2016

Researchers identify first two core genes that regulate deep sleep and dreaming

Researchers have identified the first two core genes that regulate the amount of deep sleep and dreaming, a key development they believe will lead to the discovery of a network of related genes controlling sleep.

3 Nov 2016

Researchers discover Hedgehog signaling pathway is key to formation of gastrointestinal stromal tumors

Researchers at University of California San Diego School of Medicine and Mayo Clinic provide the first evidence that the Hedgehog signaling pathway is central to the formation of gastrointestinal stromal tumors (GIST), which are frequently driven by the KIT oncogene.

1 Nov 2016

Scientists discover how MEK inhibitor boosts antitumor activity and slows cancer progression

Understanding the effects of certain targeted therapies on antitumor immunity is necessary to design combined interventions for more effective cancer treatment.

1 Nov 2016

Biovica, Eisai sign agreement to analyze DiviTum for improved cancer drug assessment in animal models

Biovica and Eisai Inc. have entered into a lab services agreement to analyze DiviTum, an assay measuring serum thymidine kinase, for improved drug evaluation in animal cancer models.

27 Oct 2016

Researchers discover new therapeutic target for controlling fatal allergic reactions

Researchers in France have identified a molecular motor that controls the release of inflammatory factors that cause severe and fatal allergic reactions.

24 Oct 2016

Scientists suggest potential approach of lowering tau levels to thwart Alzheimer's disease

Taking a pill that prevents the accumulation of toxic molecules in the brain might someday help prevent or delay Alzheimer's disease, according to scientists at Baylor College of Medicine, Texas Children's Hospital and Johns Hopkins University School of Medicine.

21 Oct 2016

Yale researchers identify chemical inhibitor that limits growth of lung tumor cells

A recently published Yale study may offer a new solution to fighting lung cancer.

20 Oct 2016

NAC improves effectiveness of adoptive cell therapy for treating melanoma

A collaborative team of investigators at the Medical University of South Carolina and Loyola University have demonstrated for the first time that culturing T cells in N-acetyl cysteine (NAC) before they are infused as immunotherapy improves effectiveness and outcomes in a preclinical model of melanoma. These findings were reported in the October 15, 2016 issue of Cancer Research.

17 Oct 2016

TSRI scientists identify new therapeutic target to combat obesity and type 2 diabetes

In a series of studies led by Assistant Professor Anutosh Chakraborty of The Scripps Research Institute Florida campus, scientists have identified a key protein that promotes fat accumulation in animal models by slowing the breakdown and expenditure of fat and encouraging weight gain.

12 Oct 2016

JAK inhibitors show promise in restoring hair growth in patients with alopecia areata

Seventy-five percent of patients with moderate to severe alopecia areata--an autoimmune disease that causes patchy, and less frequently, total hair loss--had significant hair regrowth after treatment with ruxolitinib, reported researchers from Columbia University Medical Center. By the end of their treatment, average hair regrowth was 92 percent.

5 Oct 2016

Researchers discover how appetite is controlled and influenced by the brain

Researchers from Daegu Gyeongbuk Institute of Science and Technology in Korea have uncovered the mechanisms behind the enzyme that controls our appetite in response to low glucose availability in the brain.

5 Oct 2016

Kinase News and Research

Scientists uncover novel process by which APOL1 gene contributes to renal disease

New webinar provides opportunity to learn background of MicroScale Thermophoresis

Researchers identify mechanism of how circadian clocks in neurons encode daily rhythms of excitability

Ludwig study shows how experimental drug can reverse effects of suppressive immune cells

Certain anti-diabetic drugs can switch off molecule that plays key role in inflammatory diseases

Biological scientists provide new insight into fundamental aspect of human heart function

New treatment with therapeutic short interfering RNA could help thwart cancer

Fresh insights into immune cell could signal new approach to treating life-threatening lung condition

Genetic mutation confers risk for development of Parkinson's disease earlier than usual

Researchers identify first two core genes that regulate deep sleep and dreaming

Researchers discover Hedgehog signaling pathway is key to formation of gastrointestinal stromal tumors

Scientists discover how MEK inhibitor boosts antitumor activity and slows cancer progression

Biovica, Eisai sign agreement to analyze DiviTum for improved cancer drug assessment in animal models

Researchers discover new therapeutic target for controlling fatal allergic reactions

Scientists suggest potential approach of lowering tau levels to thwart Alzheimer's disease

Yale researchers identify chemical inhibitor that limits growth of lung tumor cells

NAC improves effectiveness of adoptive cell therapy for treating melanoma

TSRI scientists identify new therapeutic target to combat obesity and type 2 diabetes

JAK inhibitors show promise in restoring hair growth in patients with alopecia areata

Researchers discover how appetite is controlled and influenced by the brain

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

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