Study reveals new mechanism that helps increase reductive power during high sugar intake

NewsGuard 100/100 Score

Animal diet has a tremendous natural variation, ranging from meat-eating carnivores to sugar-loving nectarivores. Omnivores, like humans, can adopt different types of diets and still remain healthy. However, if the diet is highly unbalanced and calorie rich, it will eventually lead to metabolic problems and disease. The genetic factors of the individual define how easily and quickly such problems develop.

"A key to the nutritional flexibility of the animals is the ability of the body to monitor its nutrient status and regulate metabolism accordingly. Many metabolic pathways depend on reduction and oxidation (redox) reactions. That is why coordinating the redox balance with cellular metabolism is critical", describes Associate Professor Ville Hietakangas from the University of Helsinki.

The system how the redox balance is controlled in response to changes of sugar feeding has so far been insufficiently understood. Now the study by Mari Teesalu, Bohdana Rovenko and Ville Hietakangas reveals a new mechanism that allows animals to increase their reductive power during conditions of high sugar intake.

"This reductive power is necessary to allow conversion of excess sugar into fat and provide protection against oxidative stress that can occur during sugar metabolism. Without the mechanism to increase the reductive power after sugar feeding larvae of fruit fly Drosophila melanogaster lose their sugar tolerance, and they are not able to grow and survive on high sugar diet", says Hietakangas.

The new regulatory mechanism involves protein kinase SIK3, which controls the activity of other proteins by phosphorylating them. SIK3 phosphorylates and activates a key enzyme of glucose metabolism called Glucose-6-phosphate dehydrogenase G6PD, which is an important regulator of cellular redox balance.

SIK3 controls G6PD in synergy with another important regulator of sugar tolerance, the sugar-sensing transcription factor complex Mondo-Mlx. Simultaneous inhibition of SIK3 and Mondo-Mlx leads to devastating consequences, causing lethality even on moderate levels of dietary sugar.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Continuous long-term ketogenic diet may induce cellular senescence in multiple organs