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Study reports an orally available SARS-CoV-2 Mpro inhibitor with potent in vivo antiviral activity

Researchers examined the efficiency of the main protease (Mpro) inhibitor against SARS-CoV-2.

29 Apr 2022

Evaluating nano alum as a substitute for conventional alum-based vaccine adjuvant

Researchers evaluated the performance and safety of nano alum adjuvant as next-generation coronavirus disease 2019 (COVID-19) vaccine antigens.

28 Apr 2022

Exploring oncolytic viral therapeutics and immunotherapies derived from DNA and RNA

A new review initially described the developments in cancer-based medicines that included vaccinations, vector-based techniques, and genome injection using DNA and RNA-based nucleic acid therapeutics.

28 Apr 2022

Cellular reprogramming can lead to better liver tissue regeneration in mice

Mammals can't typically regenerate organs as efficiently as other vertebrates, such as fish and lizards. Now, Salk scientists have found a way to partially reset liver cells to more youthful states - allowing them to heal damaged tissue at a faster rate than previously observed.

27 Apr 2022

CN Bio introduces PhysioMimix NASH ‘in-a-box’ reagent kit

First product within new ‘in-a-box’ range, which harnesses next-generation, human-relevant Liver-on-a-Chip technology to improve the accuracy and efficiency of NASH drug discovery.

From CN Bio 26 Apr 2022

Recipients for the 2022 NCCN Foundation Young Investigator Awards Program announced

The National Comprehensive Cancer Network and the NCCN Foundation today announced seven recipients for the 2022 NCCN Foundation Young Investigator Awards (YIA) Program.

25 Apr 2022

Marine resources could be promising drug candidates against SARS-CoV-2 Omicron

A recent review paper, published in the MDPI’s specialized journal COVID, highlights key features of the Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – and examines the potential and roadblocks in using renewable marine resources in the fight against the coronavirus disease 2019 (COVID-19).

24 Apr 2022

Antibodies that neutralize most sarbecoviruses, including SARS-CoV-2 variants

Researchers isolate three mAbs that broadly neutralized sarbecoviruses and carried out virological and structural studies of these mAbs.

21 Apr 2022

Intranasal nanoparticle STING agonist with immunoantiviral activity against SARS-CoV-2 variants

Researchers developed an immunoantiviral, NanoSTING, and demonstrated its broad-spectrum antiviral properties in hamsters and mice.

21 Apr 2022

New photo-responsive nanomedicine for light-controlled colorectal cancer therapy

A research team from Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong (HKUMed), has developed a photo-responsive nanomedicine for light-controlled colorectal cancer therapy.

21 Apr 2022

Cells’ exosomes can be effective vehicles for delivering cancer treatments to tumors

A new study published in Cancer Medicine indicates that exosomes, or small bubbles that transport molecules from one cell to another, can be effective vehicles for delivering cancer treatments to tumors.

20 Apr 2022

A new approach for treating multiple-drug resistant bacteria

Antibiotic-resistant hospital pathogens are not to be underestimated as a health risk. A research team has now introduced a new approach for treating multiple-drug resistant Staphylococcus in the journal Angewandte Chemie.

20 Apr 2022

CAR T-Cell Therapy: The Future of Cancer and HIV Treatment?

In this interview, News-Medical speaks to Professor Jun Huang about CAR T-cell therapy and its future as a potential treatment for cancer or HIV.

20 Apr 2022

Study evaluates the ocular tropism and the possible ocular transmission of SARS-CoV-2 in animal models

Researchers demonstrated ocular tropism of SARS-CoV-2 through neuronal invasion in transgenic mice with hACE2 expression.

20 Apr 2022

Novel targets for treating sorafenib-resistant hepatocellular carcinoma found using CRISPR-Cas9 screening

This study is led by Xiujun Cai (Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine). Professor Xiujun Cai's research team screened the whole genome of hepatocellular carcinoma cells (HepG2) through CRISPR / cas9 system under sorafenib treatment, and screened the dominant gene in sorafenib resistance.

20 Apr 2022

Researchers discover a novel signaling pathway that defines interferon responses in blood cancers

Northwestern Medicine investigators have discovered a novel signaling pathway activated by interferons, a group of immune system proteins, that suppresses the anti-tumor response of interferons in patients with a particular type of blood cancer, according to findings published in Nature Communications.

19 Apr 2022

in vivo News and Research

Study reports an orally available SARS-CoV-2 Mpro inhibitor with potent in vivo antiviral activity

Evaluating nano alum as a substitute for conventional alum-based vaccine adjuvant

Exploring oncolytic viral therapeutics and immunotherapies derived from DNA and RNA

Cellular reprogramming can lead to better liver tissue regeneration in mice

CN Bio introduces PhysioMimix NASH ‘in-a-box’ reagent kit

Recipients for the 2022 NCCN Foundation Young Investigator Awards Program announced

Marine resources could be promising drug candidates against SARS-CoV-2 Omicron

Antibodies that neutralize most sarbecoviruses, including SARS-CoV-2 variants

Intranasal nanoparticle STING agonist with immunoantiviral activity against SARS-CoV-2 variants

New photo-responsive nanomedicine for light-controlled colorectal cancer therapy

Cells’ exosomes can be effective vehicles for delivering cancer treatments to tumors

A new approach for treating multiple-drug resistant bacteria

CAR T-Cell Therapy: The Future of Cancer and HIV Treatment?

Study evaluates the ocular tropism and the possible ocular transmission of SARS-CoV-2 in animal models

Novel targets for treating sorafenib-resistant hepatocellular carcinoma found using CRISPR-Cas9 screening

Researchers discover a novel signaling pathway that defines interferon responses in blood cancers

Using customized 'mini-antibodies' to mitigate chronic inflammation

Discovery can lead to new antiviral treatments against Crimean-Congo hemorrhagic fever

Injectable hybrid inorganic nanoscaffold-templated stem cell assembly for cartilage repair

Monoclonal antibodies from COVID-19 convalescent donors target conserved site

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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