Inflammation News and Research

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Determining success or failure in cholesterol-controlling drugs

Researchers at the University of California, San Diego have discovered that a complex network of interactions between drugs and the proteins with which they bind can explain adverse drug effects. Their findings suggest that adverse drug effects might be minimized by using single or multiple drug therapies in order to fine-tune multiple off-target interactions.

15 May 2009

Cytomegalovirus may cause high blood pressure

A new study suggests for the first time that cytomegalovirus (CMV), a common viral infection affecting between 60 and 99 percent of adults worldwide, is a cause of high blood pressure, a leading risk factor for heart disease, stroke and kidney disease.

15 May 2009

Cimzia approved in U.S. for rheumatoid arthritis

UCB announced today that the U.S. Food and Drug Administration (FDA) approved Cimzia, the only PEGylated anti-TNF (Tumor Necrosis Factor), for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA).

13 May 2009

New insights into immune exhaustion

A main reason why viruses such as HIV or hepatitis C persist despite a vigorous initial immune response is exhaustion. The T cells, or white blood cells, fighting a chronic infection eventually wear out.

13 May 2009

Alzheimer's vaccine slows progression of inclusion body myositis

A potential vaccine for Alzheimer's disease also has been shown in mice to slow the weakening of muscles associated with inclusion body myositis, a disorder that affects the elderly.

13 May 2009

Diet rich in nuts and olive oil protects against age-related macular degeneration

New research has found that a diet which is low in trans fats and regularly includes nuts, olive oil and other foods containing omega-three fatty acids appears to offer some protection from the eye disease age-related macular degeneration (AMD).

13 May 2009

Discovery of pathway that reactivate myelin repair

UMDNJ researchers have identified a key pathway that could lead to new therapies to repair nerve cells' protective coating stripped away as a result of autoimmune diseases such as Multiple Sclerosis (MS). An article reporting their findings will appear in the May 13 online edition of the Journal of Neuroscience.

12 May 2009

Schering-Plough starts patient enrollment in phase 3 trial for Acadesine

Schering-Plough Corporation today announced the start of patient enrollment in RED-CABG, the Phase 3 Trial for acadesine, an investigational, potentially first-in-class adenosine regulating agent (ARA). Acadesine was licensed from PeriCor Therapeutics, Inc., a privately held specialty biopharmaceutical company.

12 May 2009

Researchers screen the smallpox proteome

University of Florida researchers have learned more about how smallpox conducts its deadly business - discoveries that may reveal as much about the human immune system as they do about one of the world's most feared pathogens.

12 May 2009

Omega-three fatty acid rich foods lower risk for eye disease

Regularly eating fish, nuts, olive oil and other foods containing omega-three fatty acids and avoiding trans fats appears to be associated with a lower risk for the eye disease age-related macular degeneration, according to two reports in the May issue of Archives of Ophthalmology.

12 May 2009

Building a bridge from Alzheimer's disease to diabetes and vice versa

Modern societies face the increasing burden of age-related diseases, in particular Alzheimer's disease (AD) and type 2 diabetes (T2D).

12 May 2009

Discovery of major new treatment target in diseased arteries

Removing a single protein prevents early damage in blood vessels from triggering a later-stage, frequently lethal complication of atherosclerosis, according to research published online today in the journal Nature Medicine. By eliminating the gene for a signaling protein called cyclophilin A (CypA) from a strain of mice, researchers were able to provide complete protection against abdominal aortic aneurysm (AAA).

11 May 2009

New understanding on mechanisms of early stage liver reperfusion injury

Reperfusion of a previously ischemic tissue is associated with additional injury leading to structural and functional alterations in many organs including the liver.

7 May 2009

Pioneering new tests and treatments for tackling airways disease highlighted

Pioneering new tests and treatments developed in Leicester for people with conditions like asthma and chronic cough are to be presented at a public event at the University of Leicester.

7 May 2009

Probiotics may help fight obesity post pregnancy

One year after giving birth, women were less likely to have the most dangerous kind of obesity if they had been given probiotics from the first trimester of pregnancy, found new research that suggests manipulating the balance of bacteria in the gut may help fight obesity.

7 May 2009

Amsterdam Molecular Therapeutics commences preregistration trial for Glybera

Amsterdam Molecular Therapeutics announced today the treatment of the first patient in a preregistration clinical trial with Glybera. This gene therapy product targets lipoprotein lipase deficiency (LPLD), a seriously debilitating and potentially lethal disease.

7 May 2009

Self-management programs for asthma improve drug adherence, disease control

Asthma patients who spend as little as 30 minutes with a health care professional to develop a personalized self-management plan show improved adherence to medications and better disease control, according to a new study by a team of researchers at the University of California, San Francisco.

6 May 2009