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High nasopharyngeal viral load in SARS-CoV-2 Omicron-induced infection

In a recent study posted to the Research Square* pre-print server, a team of researchers from Italy and the United States (US) retrospectively reviewed and compared viral load in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron and previous SARS-CoV-2 strain-induced infection.

23 Feb 2022

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

In a recent study posted to the Research Square* preprint server, which is under consideration at Scientific Reports, a team of researchers developed a novel human Alveolar Epithelial Lentivirus immortalized (hAELVi) cell infection model to estimate the replication potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory viruses in the lower respiratory tract of humans.

23 Feb 2022

SARS-CoV 2 Omicron prevalent in vaccine breakthrough cases in Bahia, Brazil

In a recent study posted to the medRxiv* pre-print server, researchers performed genomic monitoring to estimate the magnitude and range of the different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in SARS-CoV-2 reinfection cases among fully vaccinated individuals in Salvador, Bahia, Brazil.

23 Feb 2022

Pre-existing B-cell immunity against SARS-CoV-2 not detected in pre-pandemic samples

A recent study investigates samples solated from unexposed individuals pre-pandemic to determine the presence of pre-existing SARS-CoV-2 B-cell immunity.

22 Feb 2022

A blood test proves to be highly accurate in detecting early signs of Alzheimer's disease

A blood test developed at Washington University School of Medicine in St. Louis has proven highly accurate in detecting early signs of Alzheimer's disease in a study involving nearly 500 patients from across three continents, providing further evidence that the test should be considered for routine screening and diagnosis.

22 Feb 2022

Study explores the decline in viral load and immune response in COVID-19 patients

Researchers described the changes in viral ribonucleic acid the decline in viral load, and the immune response of SARS-CoV-2-infected patients, in a new preprint study.

22 Feb 2022

Severity of SARS-CoV-2 infections with Omicron BA.2 variant relative to the BA.1 variant in South Africa

Researchers estimated the clinical severity of the SARS-CoV-2 Omicron BA.2 sublineage relative to the BA.1 variant in South Africa.

22 Feb 2022

Study provides a potent biparatopic antibody against all SARS-CoV-2 variants of concern

Researchers demonstrated the potent neutralization of SARS-CoV-2 VOCs, including Omicron by the biparatopic human heavy chain variable domain.

22 Feb 2022

Widely utilized SARS-CoV-2 rapid antigen detection tests continue to perform as expected despite Omicron mutations

A recent study evaluated the performance of three at-home COVID-19 rapid antigen tests commonly used in the US against the SARS-CoV-2 Omicron variant.

22 Feb 2022

Study suggests anti-SARS-CoV-2 antibodies may persist lifelong post-infection

Researchers attempted to delineate the duration and stability of anti-SARS-CoV-2 antibodies in patients who had recovered from the COVID-19 infection.

22 Feb 2022

Time-based sensitivity of COVID-19 serological testing

In a recent study under consideration at Scientific Reports and posted to the Research Square* preprint server, researchers evaluated the impact of time on the sensitivity of four severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological assays using samples from the coronavirus disease 2019 (COVID-19) staff testing of antibody responses study(Co-Stars) in the United Kingdom (UK).

22 Feb 2022

Research explains how SARS-CoV-2 variants evade some antibodies

A recent study published in the iScience Journal assessed the influence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on coronavirus disease 2019 (COVID-19) infectivity and viral neutralization.

22 Feb 2022

Using IgG antibody assay to Identify natural SARS-CoV-2 infection in vaccinees

A recent study published in the journal of Mayo Clinic Proceedings predicted the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) natural infection in vaccinated individuals.

21 Feb 2022

Broad-spectrum antiviral activity of picolinic acid against SARS-CoV-2 and Influenza A virus

Researchers investigate the potential of picolinic acid (PA) as an anti-SARS-CoV-2 treatment option.

21 Feb 2022

Novel ACE2-blocking antibody protects against all SARS-CoV-2 VOCs

Researchers identify 87G7, a SARS-CoV-2 neutralizing human monoclonal antibody with remarkable broad-spectrum neutralization and protection efficacy.

21 Feb 2022

Monitoring rise of SARS-CoV-2 variants in wastewater using genome sequencing

Researchers conduct genomic wastewater surveillance of SARS-CoV-2 following the emergence of the Alpha and Delta variants in the United Kingdom.

21 Feb 2022

Study reports potently neutralizing mucosal IgA in saliva of BNT162b2 vaccine recipients

researchers determine the strong neutralizing mucosal component emanating from intramuscular administration of an mRNA vaccine.

21 Feb 2022

The logic that controls gene regulation in human cells discovered

A research group at the University of Helsinki has discovered the logic that controls gene regulation in human cells. In the future, this new knowledge can be applied to, for example, investigating cancers and other genetic diseases.

21 Feb 2022

Mechanisms of IL-6 expression in peripheral monocyte-derived macrophages infected with SARS-CoV-2

Researchers examined the detailed mechanisms of ‘cytokine storm’ that induces ARDS, often resulting in the death of severely ill COVID-19 patients.

21 Feb 2022

Full schedule of CoronaVac vaccine shown to be highly effective in children

A recent study on vaccine effectiveness showed that a complete primary immunization with CoronaVac effectively protects against severe coronavirus disease 2019 (COVID-19) for children and adolescents between 6 and 16 years of age – consistent with the results from phase 2 clinical trials. The paper is currently available on the Preprints with The Lancet* server while it undergoes peer review.

20 Feb 2022

Assay News and Research

High nasopharyngeal viral load in SARS-CoV-2 Omicron-induced infection

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

SARS-CoV 2 Omicron prevalent in vaccine breakthrough cases in Bahia, Brazil

Pre-existing B-cell immunity against SARS-CoV-2 not detected in pre-pandemic samples

A blood test proves to be highly accurate in detecting early signs of Alzheimer's disease

Study explores the decline in viral load and immune response in COVID-19 patients

Severity of SARS-CoV-2 infections with Omicron BA.2 variant relative to the BA.1 variant in South Africa

Study provides a potent biparatopic antibody against all SARS-CoV-2 variants of concern

Widely utilized SARS-CoV-2 rapid antigen detection tests continue to perform as expected despite Omicron mutations

Study suggests anti-SARS-CoV-2 antibodies may persist lifelong post-infection

Time-based sensitivity of COVID-19 serological testing

Research explains how SARS-CoV-2 variants evade some antibodies

Using IgG antibody assay to Identify natural SARS-CoV-2 infection in vaccinees

Broad-spectrum antiviral activity of picolinic acid against SARS-CoV-2 and Influenza A virus

Novel ACE2-blocking antibody protects against all SARS-CoV-2 VOCs

Monitoring rise of SARS-CoV-2 variants in wastewater using genome sequencing

Study reports potently neutralizing mucosal IgA in saliva of BNT162b2 vaccine recipients

The logic that controls gene regulation in human cells discovered

Mechanisms of IL-6 expression in peripheral monocyte-derived macrophages infected with SARS-CoV-2

Full schedule of CoronaVac vaccine shown to be highly effective in children

Measuring Drug-Target Residence Times with Biochemical Assays eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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